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On The Cover: The crystal structure of the bilobal iron transport protein, human serum transferrin (lacking ferric iron), is shown. The C-lobe (red-orange-yellow) and the N-lobe (green-blue) are almost equally open. One binding cleft with the four iron-liganding residues (red) waiting to capture iron is highlighted. Transferrin functions to prevent hydrolysis and maintain iron in soluble form for delivery to cells. For details see the article by Wally et al., pages 24934–24944.
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