JBC -- Table of Contents (Dec 29 2006, 281, (52))

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Stephen G. Young, Margarita Meta, Shao H. Yang, and Loren G. Fong: Prelamin A Farnesylation and Progeroid Syndromes
J. Biol. Chem. 2006 281: 39741-39745. First Published on November 7, 2006; doi:10.1074/jbc.R600033200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Michelle J. Henderson, Marcia A. Munoz, Darren N. Saunders, Jennifer L. Clancy, Amanda J. Russell, Brandi Williams, Darryl Pappin, Kum Kum Khanna, Stephen P. Jackson, Robert L. Sutherland, and Colin K. W. Watts: EDD Mediates DNA Damage-induced Activation of CHK2
J. Biol. Chem. 2006 281: 39990-40000. First Published on October 30, 2006; doi:10.1074/jbc.M602818200 [Abstract] [Full Text] [PDF]

Yun Wu, Joseph S. Siino, Tomohiko Sugiyama, and Stephen C. Kowalczykowski: The DNA Binding Preference of RAD52 and RAD59 Proteins: IMPLICATIONS FOR RAD52 AND RAD59 PROTEIN FUNCTION IN HOMOLOGOUS RECOMBINATION
J. Biol. Chem. 2006 281: 40001-40009. First Published on October 12, 2006; doi:10.1074/jbc.M608071200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Raffaella Faraonio, Paola Vergara, Domenico Di Marzo, Maria Giovanna Pierantoni, Maria Napolitano, Tommaso Russo, and Filiberto Cimino: p53 Suppresses the Nrf2-dependent Transcription of Antioxidant Response Genes
J. Biol. Chem. 2006 281: 39776-39784. First Published on October 31, 2006; doi:10.1074/jbc.M605707200 [Abstract] [Full Text] [PDF]

Tonghuan Hu, Michael Chouinard, Amy L. Cox, Philip Sipes, Marialuisa Marcelo, James Ficorilli, Shuyu Li, Hong Gao, Timothy P. Ryan, M. Dodson Michael, and Laura F. Michael: Farnesoid X Receptor Agonist Reduces Serum Asymmetric Dimethylarginine Levels through Hepatic Dimethylarginine Dimethylaminohydrolase-1 Gene Regulation
J. Biol. Chem. 2006 281: 39831-39838. First Published on October 25, 2006; doi:10.1074/jbc.M606779200 [Abstract] [Full Text] [PDF]

Maria Simonsson, Meena Kanduri, Eva Grönroos, Carl-Henrik Heldin, and Johan Ericsson: The DNA Binding Activities of Smad2 and Smad3 Are Regulated by Coactivator-mediated Acetylation
J. Biol. Chem. 2006 281: 39870-39880. First Published on October 30, 2006; doi:10.1074/jbc.M607868200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yi Zhang, Ke Ma, Prabodh Sadana, Farhana Chowdhury, Stephanie Gaillard, Fang Wang, Donald P. McDonnell, Terry G. Unterman, Marshall B. Elam, and Edwards A. Park: Estrogen-related Receptors Stimulate Pyruvate Dehydrogenase Kinase Isoform 4 Gene Expression
J. Biol. Chem. 2006 281: 39897-39906. First Published on November 1, 2006; doi:10.1074/jbc.M608657200 [Abstract] [Full Text] [PDF]

Evelyne Myslinski, Marie-Aline Gérard, Alain Krol, and Philippe Carbon: A Genome Scale Location Analysis of Human Staf/ZNF143-binding Sites Suggests a Widespread Role for Human Staf/ZNF143 in Mammalian Promoters
J. Biol. Chem. 2006 281: 39953-39962. First Published on November 7, 2006; doi:10.1074/jbc.M608507200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sudeshna Kar, Eugene J. Choi, Fusheng Guo, Emilios K. Dimitriadis, Svetlana L. Kotova, and Sankar Adhya: Right-handed DNA Supercoiling by an Octameric Form of Histone-like Protein HU: MODULATION OF CELLULAR TRANSCRIPTION
J. Biol. Chem. 2006 281: 40144-40153. First Published on October 23, 2006; doi:10.1074/jbc.M605576200 [Abstract] [Full Text] [PDF]

Muyao Li, Jen-Fu Chiu, Brooke T. Mossman, and Naomi K. Fukagawa: Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats
J. Biol. Chem. 2006 281: 40429-40439. First Published on November 1, 2006; doi:10.1074/jbc.M606596200 [Abstract] [Full Text] [PDF]

RNA: Structure, Metabolism, and Catalysis:

Kimio J. Tanaka, Kenji Ogawa, Masatoshi Takagi, Naoko Imamoto, Ken Matsumoto, and Masafumi Tsujimoto: RAP55, a Cytoplasmic mRNP Component, Represses Translation in Xenopus Oocytes
J. Biol. Chem. 2006 281: 40096-40106. First Published on October 30, 2006; doi:10.1074/jbc.M609059200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Synthesis, Post-Translation Modification, and Degradation:

Nathalie Pierrot, Susana Ferrao Santos, Christine Feyt, Marina Morel, Jean-Pierre Brion, and Jean-Noël Octave: Calcium-mediated Transient Phosphorylation of Tau and Amyloid Precursor Protein Followed by Intraneuronal Amyloid- $beta$ Accumulation
J. Biol. Chem. 2006 281: 39907-39914. First Published on November 3, 2006; doi:10.1074/jbc.M606015200 [Abstract] [Full Text] [PDF]

Sara Guil, Marta Rodríguez-Castro, Francisco Aguilar, Eugenia M. Villasevil, Luis C. Antón, and Margarita Del Val: Need for Tripeptidyl-peptidase II in Major Histocompatibility Complex Class I Viral Antigen Processing when Proteasomes are Detrimental
J. Biol. Chem. 2006 281: 39925-39934. First Published on November 6, 2006; doi:10.1074/jbc.M608522200 [Abstract] [Full Text] [PDF]

Marek Sramko, Ján Markus, Juraj Kabát, Linda Wolff, and Juraj Bies: Stress-induced Inactivation of the c-Myb Transcription Factor through Conjugation of SUMO-2/3 Proteins
J. Biol. Chem. 2006 281: 40065-40075. First Published on October 30, 2006; doi:10.1074/jbc.M609404200 [Abstract] [Full Text] [PDF]

Gregory D. Salinas, Leslie A. C. Blair, Leigh A. Needleman, Justina D. Gonzales, Ying Chen, Min Li, Jeffrey D. Singer, and John Marshall: Actinfilin Is a Cul3 Substrate Adaptor, Linking GluR6 Kainate Receptor Subunits to the Ubiquitin-Proteasome Pathway
J. Biol. Chem. 2006 281: 40164-40173. First Published on October 24, 2006; doi:10.1074/jbc.M608194200 [Abstract] [Full Text] [PDF]

Vera P. Pisareva, Andrey V. Pisarev, Christopher U. T. Hellen, Marina V. Rodnina, and Tatyana V. Pestova: Kinetic Analysis of Interaction of Eukaryotic Release Factor 3 with Guanine Nucleotides
J. Biol. Chem. 2006 281: 40224-40235. First Published on October 24, 2006; doi:10.1074/jbc.M607461200 [Abstract] [Full Text] [PDF]

Jian Shi, Hanane A. Koteiche, Hassane S. Mchaourab, and Phoebe L. Stewart: Cryoelectron Microscopy and EPR Analysis of Engineered Symmetric and Polydisperse Hsp16.5 Assemblies Reveals Determinants of Polydispersity and Substrate Binding
J. Biol. Chem. 2006 281: 40420-40428. First Published on October 31, 2006; doi:10.1074/jbc.M608322200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Structure and Folding:

Eman Basha, Kenneth L. Friedrich, and Elizabeth Vierling: The N-terminal Arm of Small Heat Shock Proteins Is Important for Both Chaperone Activity and Substrate Specificity
J. Biol. Chem. 2006 281: 39943-39952. First Published on November 7, 2006; doi:10.1074/jbc.M607677200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Raul Perez-Jimenez, Sergi Garcia-Manyes, Sri Rama Koti Ainavarapu, and Julio M. Fernandez: Mechanical Unfolding Pathways of the Enhanced Yellow Fluorescent Protein Revealed by Single Molecule Force Spectroscopy
J. Biol. Chem. 2006 281: 40010-40014. First Published on November 2, 2006; doi:10.1074/jbc.M609890200 [Abstract] [Full Text] [PDF]

Mitsuhiro Takeda, Shinji Ogino, Ryo Umemoto, Masayoshi Sakakura, Masahiro Kajiwara, Kazuki N. Sugahara, Haruko Hayasaka, Masayuki Miyasaka, Hiroaki Terasawa, and Ichio Shimada: Ligand-induced Structural Changes of the CD44 Hyaluronan-binding Domain Revealed by NMR
J. Biol. Chem. 2006 281: 40089-40095. First Published on November 2, 2006; doi:10.1074/jbc.M608425200 [Abstract] [Full Text] [PDF]

Meghna Thakur and Pradip K. Chakraborti: GTPase Activity of Mycobacterial FtsZ Is Impaired Due to Its Transphosphorylation by the Eukaryotic-type Ser/Thr Kinase, PknA
J. Biol. Chem. 2006 281: 40107-40113. First Published on October 26, 2006; doi:10.1074/jbc.M607216200 [Abstract] [Full Text] [PDF]

Pawel Buczek and Martin P. Horvath: Structural Reorganization and the Cooperative Binding of Single-stranded Telomere DNA in Sterkiella nova
J. Biol. Chem. 2006 281: 40124-40134. First Published on November 2, 2006; doi:10.1074/jbc.M607749200 [Abstract] [Full Text] [PDF]

Rémy Robert, Marie-Josée Jacobin-Valat, Danièle Daret, Sylvain Miraux, Alan T. Nurden, Jean-Michel Franconi, and Gisèle Clofent-Sanchez: Identification of Human scFvs Targeting Atherosclerotic Lesions: SELECTION BY SINGLE ROUND IN VIVO PHAGE DISPLAY
J. Biol. Chem. 2006 281: 40135-40143. First Published on October 26, 2006; doi:10.1074/jbc.M609344200 [Abstract] [Full Text] [PDF]

Danielle Johnston, Christine Tavano, Sue Wickner, and Nancy Trun: Specificity of DNA Binding and Dimerization by CspE from Escherichia coli
J. Biol. Chem. 2006 281: 40208-40215. First Published on November 4, 2006; doi:10.1074/jbc.M606414200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Martin Kawe, Patrik Forrer, Patrick Amstutz, and Andreas Plückthun: Isolation of Intracellular Proteinase Inhibitors Derived from Designed Ankyrin Repeat Proteins by Genetic Screening
J. Biol. Chem. 2006 281: 40252-40263. First Published on October 18, 2006; doi:10.1074/jbc.M602506200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Anna Roujeinikova, Nigel S. Scrutton, and David Leys: Atomic Level Insight into the Oxidative Half-reaction of Aromatic Amine Dehydrogenase
J. Biol. Chem. 2006 281: 40264-40272. First Published on September 27, 2006; doi:10.1074/jbc.M605559200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yusuke Kato, Takuya Miyakawa, Jun-ichi Kurita, and Masaru Tanokura: Structure of FBP11 WW1-PL Ligand Complex Reveals the Mechanism of Proline-rich Ligand Recognition by Group II/III WW Domains
J. Biol. Chem. 2006 281: 40321-40329. First Published on October 24, 2006; doi:10.1074/jbc.M609321200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Crina Paduraru, Laurentiu Spiridon, Weiming Yuan, Gabriel Bricard, Xavier Valencia, Steven A. Porcelli, Petr A. Illarionov, Gurdyal S. Besra, Stefana M. Petrescu, Andrei-Jose Petrescu, and Peter Cresswell: An N-Linked Glycan Modulates the Interaction between the CD1d Heavy Chain and $beta$ ₂-Microglobulin
J. Biol. Chem. 2006 281: 40369-40378. First Published on October 27, 2006; doi:10.1074/jbc.M608518200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Alaji Bah, Laura C. Garvey, Jingping Ge, and Enrico Di Cera: Rapid Kinetics of Na⁺ Binding to Thrombin
J. Biol. Chem. 2006 281: 40049-40056. First Published on October 30, 2006; doi:10.1074/jbc.M608600200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Young Sung Yun, Wook Lee, Sejeong Shin, Byung-Ha Oh, and Kwan Yong Choi: Arg-158 Is Critical in Both Binding the Substrate and Stabilizing the Transition-state Oxyanion for the Enzymatic Reaction of Malonamidase E2
J. Biol. Chem. 2006 281: 40057-40064. First Published on October 31, 2006; doi:10.1074/jbc.M604515200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Buhyun Youn, Sung-Jin Kim, Syed G. A. Moinuddin, Choonseok Lee, Diana L. Bedgar, Athena R. Harper, Laurence B. Davin, Norman G. Lewis, and ChulHee Kang: Mechanistic and Structural Studies of Apoform, Binary, and Ternary Complexes of the Arabidopsis Alkenal Double Bond Reductase At5g16970
J. Biol. Chem. 2006 281: 40076-40088. First Published on October 6, 2006; doi:10.1074/jbc.M605900200 [Abstract] [Full Text] [PDF]

Vladi V. Heredia, Thomas J. Carlson, Erin Garcia, and Shaoxian Sun: Biochemical Basis of Glucokinase Activation and the Regulation by Glucokinase Regulatory Protein in Naturally Occurring Mutations
J. Biol. Chem. 2006 281: 40201-40207. First Published on November 2, 2006; doi:10.1074/jbc.M607987200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Balasubramanyam Karanam, Lihua Jiang, Ling Wang, Neil L. Kelleher, and Philip A. Cole: Kinetic and Mass Spectrometric Analysis of p300 Histone Acetyltransferase Domain Autoacetylation
J. Biol. Chem. 2006 281: 40292-40301. First Published on October 25, 2006; doi:10.1074/jbc.M608813200 [Abstract] [Full Text] [PDF]

Clarisa Maria Bejar, Xiangshu Jin, Miguel Angel Ballicora, and Jack Preiss: Molecular Architecture of the Glucose 1-Phosphate Site in ADP-glucose Pyrophosphorylases
J. Biol. Chem. 2006 281: 40473-40484. First Published on November 1, 2006; doi:10.1074/jbc.M607088200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Metabolism and Bioenergetics:

Yunxia O'Malley, Brian D. Fink, Nicolette C. Ross, Thomas E. Prisinzano, and William I. Sivitz: Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria
J. Biol. Chem. 2006 281: 39766-39775. First Published on October 23, 2006; doi:10.1074/jbc.M608268200 [Abstract] [Full Text] [PDF]

Christine C. Winterbourn, Mark B. Hampton, John H Livesey, and Anthony J. Kettle: Modeling the Reactions of Superoxide and Myeloperoxidase in the Neutrophil Phagosome: IMPLICATIONS FOR MICROBIAL KILLING
J. Biol. Chem. 2006 281: 39860-39869. First Published on October 30, 2006; doi:10.1074/jbc.M605898200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Liping Qiao and Jianhua Shao: SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein ${alpha}$ Transcriptional Complex
J. Biol. Chem. 2006 281: 39915-39924. First Published on November 6, 2006; doi:10.1074/jbc.M607215200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yingda Wang, James K. Oeser, Chunmei Yang, Suparna Sarkar, Seija I. Hackl, Alyssa H. Hasty, Owen P. McGuinness, William Paradee, John C. Hutton, David R. Powell, and Richard M. O'Brien: Deletion of the Gene Encoding the Ubiquitously Expressed Glucose-6-phosphatase Catalytic Subunit-related Protein (UGRP)/Glucose-6-phosphatase Catalytic Subunit- $beta$ Results in Lowered Plasma Cholesterol and Elevated Glucagon
J. Biol. Chem. 2006 281: 39982-39989. First Published on October 5, 2006; doi:10.1074/jbc.M605858200 [Abstract] [Full Text] [PDF]

Bas Teusink, Anne Wiersma, Douwe Molenaar, Christof Francke, Willem M. de Vos, Roland J. Siezen, and Eddy J. Smid: Analysis of Growth of Lactobacillus plantarum WCFS1 on a Complex Medium Using a Genome-scale Metabolic Model
J. Biol. Chem. 2006 281: 40041-40048. First Published on October 24, 2006; doi:10.1074/jbc.M606263200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Scot J. Stone, Malin C. Levin, and Robert V. Farese, Jr.: Membrane Topology and Identification of Key Functional Amino Acid Residues of Murine Acyl-CoA:Diacylglycerol Acyltransferase-2
J. Biol. Chem. 2006 281: 40273-40282. First Published on October 10, 2006; doi:10.1074/jbc.M607986200 [Abstract] [Full Text] [PDF]

Glycobiology and Extracellular Matrices:

Solange M. T. Serrano, Junho Kim, Deyu Wang, Bojan Dragulev, John D. Shannon, Henning H. Mann, Guido Veit, Raimund Wagener, Manuel Koch, and Jay W. Fox: The Cysteine-rich Domain of Snake Venom Metalloproteinases Is a Ligand for von Willebrand Factor A Domains: ROLE IN SUBSTRATE TARGETING*
J. Biol. Chem. 2006 281: 39746-39756. First Published on October 13, 2006; doi:10.1074/jbc.M604855200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Xiaoying Zhou, Aqeel Jamil, Andrew Nash, James Chan, Nathan Trim, John P. Iredale, and R. Christopher Benyon: Impaired Proteolysis of Collagen I Inhibits Proliferation of Hepatic Stellate Cells: IMPLICATIONS FOR REGULATION OF LIVER FIBROSIS
J. Biol. Chem. 2006 281: 39757-39765. First Published on October 23, 2006; doi:10.1074/jbc.M605621200 [Abstract] [Full Text] [PDF]

Kate L. Fox, Andrew D. Cox, Michel Gilbert, Warren W. Wakarchuk, Jianjun Li, Katherine Makepeace, James C. Richards, E. Richard Moxon, and Derek W. Hood: Identification of a Bifunctional Lipopolysaccharide Sialyltransferase in Haemophilus influenzae: INCORPORATION OF DISIALIC ACID
J. Biol. Chem. 2006 281: 40024-40032. First Published on October 27, 2006; doi:10.1074/jbc.M602314200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Giacomo Pardini, Piet W. J. De Groot, Alix T. Coste, Mahir Karababa, Frans M. Klis, Chris G. de Koster, and Dominique Sanglard: The CRH Family Coding for Cell Wall Glycosylphosphatidylinositol Proteins with a Predicted Transglycosidase Domain Affects Cell Wall Organization and Virulence of Candida albicans
J. Biol. Chem. 2006 281: 40399-40411. First Published on October 30, 2006; doi:10.1074/jbc.M606361200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Lipids and Lipoproteins:

Gongshe Han, Kenneth Gable, Lianying Yan, Michael J. Allen, William H. Wilson, Prasun Moitra, Jeffrey M. Harmon, and Teresa M. Dunn: Expression of a Novel Marine Viral Single-chain Serine Palmitoyltransferase and Construction of Yeast and Mammalian Single-chain Chimera
J. Biol. Chem. 2006 281: 39935-39942. First Published on November 6, 2006; doi:10.1074/jbc.M609365200 [Abstract] [Full Text] [PDF]

Bassam Haidar, Robert S. Kiss, Lea Sarov-Blat, Roch Brunet, Christopher Harder, Ruth McPherson, and Yves L. Marcel: Cathepsin D, a Lysosomal Protease, Regulates ABCA1-mediated Lipid Efflux
J. Biol. Chem. 2006 281: 39971-39981. First Published on October 10, 2006; doi:10.1074/jbc.M605095200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Martina Schweiger, Renate Schreiber, Guenter Haemmerle, Achim Lass, Christian Fledelius, Poul Jacobsen, Hans Tornqvist, Rudolf Zechner, and Robert Zimmermann: Adipose Triglyceride Lipase and Hormone-sensitive Lipase Are the Major Enzymes in Adipose Tissue Triacylglycerol Catabolism
J. Biol. Chem. 2006 281: 40236-40241. First Published on October 30, 2006; doi:10.1074/jbc.M608048200 [Abstract] [Full Text] [PDF]

Byung-Hyun Park, May-Yun Wang, Young Lee, Xinxin Yu, Mariella Ravazzola, Lelio Orci, and Roger H. Unger: Combined Leptin Actions on Adipose Tissue and Hypothalamus Are Required to Deplete Adipocyte Fat in Lean Rats: IMPLICATIONS FOR OBESITY TREATMENT
J. Biol. Chem. 2006 281: 40283-40291. First Published on October 12, 2006; doi:10.1074/jbc.M607545200 [Abstract] [Full Text] [PDF]

Antje Lohmann, Mark Aurel Schöttler, Claire Bréhélin, Felix Kessler, Ralph Bock, Edgar B. Cahoon, and Peter Dörmann: Deficiency in Phylloquinone (Vitamin K₁) Methylation Affects Prenyl Quinone Distribution, Photosystem I Abundance, and Anthocyanin Accumulation in the Arabidopsis AtmenG Mutant
J. Biol. Chem. 2006 281: 40461-40472. First Published on November 2, 2006; doi:10.1074/jbc.M609412200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Christopher L. Perria, Vijayalakshmi Rajamanickam, Philip E. Lapinski, and Malini Raghavan: Catalytic Site Modifications of TAP1 and TAP2 and Their Functional Consequences
J. Biol. Chem. 2006 281: 39839-39851. First Published on October 26, 2006; doi:10.1074/jbc.M605492200 [Abstract] [Full Text] [PDF]

Dan Su, James M. May, Mark J. Koury, and Han Asard: Human Erythrocyte Membranes Contain a Cytochrome b₅₆₁ That May Be Involved in Extracellular Ascorbate Recycling
J. Biol. Chem. 2006 281: 39852-39859. First Published on October 26, 2006; doi:10.1074/jbc.M606543200 [Abstract] [Full Text] [PDF]

Panayiota Karatza, Panayiotis Panos, Ekaterini Georgopoulou, and Stathis Frillingos: Cysteine-scanning Analysis of the Nucleobase-Ascorbate Transporter Signature Motif in YgfO Permease of Escherichia coli: Gln-324 AND Asn-325 ARE ESSENTIAL, AND Ile-329–Val-339 FORM AN ${alpha}$ -HELIX
J. Biol. Chem. 2006 281: 39881-39890. First Published on October 31, 2006; doi:10.1074/jbc.M605748200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Kshama D. Chandrasekhar, Tuba Bas, and William R. Kobertz: KCNE1 Subunits Require Co-assembly with K⁺ Channels for Efficient Trafficking and Cell Surface Expression
J. Biol. Chem. 2006 281: 40015-40023. First Published on October 24, 2006; doi:10.1074/jbc.M604398200 [Abstract] [Full Text] [PDF]

Yung-Hui Kuan, Tomas Gruebl, Peter Soba, Simone Eggert, Iva Nesic, Simone Back, Joachim Kirsch, Konrad Beyreuther, and Stefan Kins: PAT1a Modulates Intracellular Transport and Processing of Amyloid Precursor Protein (APP), APLP1, and APLP2
J. Biol. Chem. 2006 281: 40114-40123. First Published on October 18, 2006; doi:10.1074/jbc.M605407200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Fabien Vanden Abeele, Alexander Zholos, Gabriel Bidaux, Yaroslav Shuba, Stephanie Thebault, Benjamin Beck, Matthieu Flourakis, Yuri Panchin, Roman Skryma, and Natalia Prevarskaya: Ca²⁺-independent Phospholipase A₂-dependent Gating of TRPM8 by Lysophospholipids
J. Biol. Chem. 2006 281: 40174-40182. First Published on November 2, 2006; doi:10.1074/jbc.M605779200 [Abstract] [Full Text] [PDF]

Torsten Martin, Rita Sharma, Claudia Sippel, Karin Waegemann, Jürgen Soll, and Ute C. Vothknecht: A Protein Kinase Family in Arabidopsis Phosphorylates Chloroplast Precursor Proteins
J. Biol. Chem. 2006 281: 40216-40223. First Published on November 7, 2006; doi:10.1074/jbc.M606580200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Paula Aracena-Parks, Sanjeewa A. Goonasekera, Charles P. Gilman, Robert T. Dirksen, Cecilia Hidalgo, and Susan L. Hamilton: Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1
J. Biol. Chem. 2006 281: 40354-40368. First Published on October 27, 2006; doi:10.1074/jbc.M600876200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Masanobu Takeji, Toshiki Moriyama, Susumu Oseto, Noritaka Kawada, Masatsugu Hori, Enyu Imai, and Takeshi Miwa: Smooth Muscle ${alpha}$ -Actin Deficiency in Myofibroblasts Leads to Enhanced Renal Tissue Fibrosis
J. Biol. Chem. 2006 281: 40193-40200. First Published on November 6, 2006; doi:10.1074/jbc.M602182200 [Abstract] [Full Text] [PDF]

Laxman Gangwani: Deficiency of the Zinc Finger Protein ZPR1 Causes Defects in Transcription and Cell Cycle Progression
J. Biol. Chem. 2006 281: 40330-40340. First Published on October 26, 2006; doi:10.1074/jbc.M608165200 [Abstract] [Full Text] [PDF]

Keith E. Fox, Dana M. Fankell, Paul F. Erickson, Susan M. Majka, Joseph T. Crossno, Jr., and Dwight J. Klemm: Depletion of cAMP-response Element-binding Protein/ATF1 Inhibits Adipogenic Conversion of 3T3-L1 Cells Ectopically Expressing CCAAT/Enhancer-binding Protein (C/EBP) ${alpha}$ , C/EBP $beta$ , or PPAR ${gamma}$ 2
J. Biol. Chem. 2006 281: 40341-40353. First Published on October 27, 2006; doi:10.1074/jbc.M605077200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hui Chen, Dilshad M. Choudhury, and Susan W. Craig: Coincidence of Actin Filaments and Talin Is Required to Activate Vinculin
J. Biol. Chem. 2006 281: 40389-40398. First Published on October 29, 2006; doi:10.1074/jbc.M607324200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Takeshi Uchiumi, Abbas Fotovati, Takakazu Sasaguri, Kohtaro Shibahara, Tatsuo Shimada, Takao Fukuda, Takanori Nakamura, Hiroto Izumi, Teruhisa Tsuzuki, Michihiko Kuwano, and Kimitoshi Kohno: YB-1 Is Important for an Early Stage Embryonic Development: NEURAL TUBE FORMATION AND CELL PROLIFERATION
J. Biol. Chem. 2006 281: 40440-40449. First Published on November 2, 2006; doi:10.1074/jbc.M605948200 [Abstract] [Full Text] [PDF] [ Supplemental Data]

Tae-Hee Lee, Seyha Seng, Huchun Li, Stephen J. Kennel, Hava Karsenty Avraham, and Shalom Avraham: Integrin Regulation by Vascular Endothelial Growth Factor in Human Brain Microvascular Endothelial Cells: ROLE OF ${alpha}$ ₆ $beta$ ₁ INTEGRIN IN ANGIOGENESIS
J. Biol. Chem. 2006 281: 40450-40460. First Published on November 2, 2006; doi:10.1074/jbc.M607525200 [Abstract] [Full Text] [PDF]

Bryce Patrick Portier and Giulio Taglialatela: Bcl-2 Localized at the Nuclear Compartment Induces Apoptosis after Transient Overexpression
J. Biol. Chem. 2006 281: 40493-40502. First Published on November 7, 2006; doi:10.1074/jbc.M606181200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mohammad Q. Hassan, Rahul S. Tare, Suk Hee Lee, Matthew Mandeville, Maria I. Morasso, Amjad Javed, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian: BMP2 Commitment to the Osteogenic Lineage Involves Activation of Runx2 by DLX3 and a Homeodomain Transcriptional Network
J. Biol. Chem. 2006 281: 40515-40526. First Published on October 23, 2006; doi:10.1074/jbc.M604508200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mechanisms Of Signal Transduction:

Raquel Serrano, Humberto Martín, Antonio Casamayor, and Joaquín Ariño: Signaling Alkaline pH Stress in the Yeast Saccharomyces cerevisiae through the Wsc1 Cell Surface Sensor and the Slt2 MAPK Pathway
J. Biol. Chem. 2006 281: 39785-39795. First Published on November 6, 2006; doi:10.1074/jbc.M604497200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Joseph D. Sherrill and William E. Miller: G Protein-coupled Receptor (GPCR) Kinase 2 Regulates Agonist-independent G_q/11 Signaling from the Mouse Cytomegalovirus GPCR M33
J. Biol. Chem. 2006 281: 39796-39805. First Published on November 6, 2006; doi:10.1074/jbc.M610026200 [Abstract] [Full Text] [PDF]

Jiyuan Ke, Murali Gururajan, Anupam Kumar, Alan Simmons, Lilia Turcios, Ralph L. Chelvarajan, David M. Cohen, David L. Wiest, John G. Monroe, and Subbarao Bondada: The Role of MAPKs in B Cell Receptor-induced Down-regulation of Egr-1 in Immature B Lymphoma Cells
J. Biol. Chem. 2006 281: 39806-39818. First Published on October 24, 2006; doi:10.1074/jbc.M604671200 [Abstract] [Full Text] [PDF]

Muthusamy Kunnimalaiyaan, Abram M. Vaccaro, Mary A. Ndiaye, and Herbert Chen: Overexpression of the NOTCH1 Intracellular Domain Inhibits Cell Proliferation and Alters the Neuroendocrine Phenotype of Medullary Thyroid Cancer Cells
J. Biol. Chem. 2006 281: 39819-39830. First Published on November 7, 2006; doi:10.1074/jbc.M603578200 [Abstract] [Full Text] [PDF]

Taisuke Kajino, Hong Ren, Shun-ichiro Iemura, Tohru Natsume, Bjarki Stefansson, David L. Brautigan, Kunihiro Matsumoto, and Jun Ninomiya-Tsuji: Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway
J. Biol. Chem. 2006 281: 39891-39896. First Published on November 1, 2006; doi:10.1074/jbc.M608155200 [Abstract] [Full Text] [PDF]

Gorazd Drozina, Jiri Kohoutek, Tadashi Nishiya, and B. Matija Peterlin: Sequential Modifications in Class II Transactivator Isoform 1 Induced by Lipopolysaccharide Stimulate Major Histocompatibility Complex Class II Transcription in Macrophages
J. Biol. Chem. 2006 281: 39963-39970. First Published on November 9, 2006; doi:10.1074/jbc.M608538200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sebastian P. van der Woning, Walter van Rotterdam, Sander B. Nabuurs, Hanka Venselaar, Saskia Jacobs-Oomen, Miriam Wingens, Gert Vriend, Catelijne Stortelers, and Everardus J. J. van Zoelen: Negative Constraints Underlie the ErbB Specificity of Epidermal Growth Factor-like Ligands
J. Biol. Chem. 2006 281: 40033-40040. First Published on October 10, 2006; doi:10.1074/jbc.M603168200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Julia V. Gerasimenko, Sarah E. Flowerdew, Svetlana G. Voronina, Tatiana K. Sukhomlin, Alexei V. Tepikin, Ole H. Petersen, and Oleg V. Gerasimenko: Bile Acids Induce Ca²⁺ Release from Both the Endoplasmic Reticulum and Acidic Intracellular Calcium Stores through Activation of Inositol Trisphosphate Receptors and Ryanodine Receptors
J. Biol. Chem. 2006 281: 40154-40163. First Published on October 30, 2006; doi:10.1074/jbc.M606402200 [Abstract] [Full Text] [PDF]

Marianela Perez-Torres, Marta Guix, Adriana Gonzalez, and Carlos L. Arteaga: Epidermal Growth Factor Receptor (EGFR) Antibody Down-regulates Mutant Receptors and Inhibits Tumors Expressing EGFR Mutations
J. Biol. Chem. 2006 281: 40183-40192. First Published on November 1, 2006; doi:10.1074/jbc.M607958200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Yongheng Cao, Yuji Kamioka, Norihide Yokoi, Toshiyuki Kobayashi, Okio Hino, Masafumi Onodera, Naoki Mochizuki, and Jun Nakae: Interaction of FoxO1 and TSC2 Induces Insulin Resistance through Activation of the Mammalian Target of Rapamycin/p70 S6K Pathway
J. Biol. Chem. 2006 281: 40242-40251. First Published on October 31, 2006; doi:10.1074/jbc.M608116200 [Abstract] [Full Text] [PDF]

Ariel Quintana, Eva C. Schwarz, Christian Schwindling, Peter Lipp, Lars Kaestner, and Markus Hoth: Sustained Activity of Calcium Release-activated Calcium Channels Requires Translocation of Mitochondria to the Plasma Membrane
J. Biol. Chem. 2006 281: 40302-40309. First Published on October 20, 2006; doi:10.1074/jbc.M607896200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Violaine Simon, Jessie Guidry, Thomas W. Gettys, Andrew B. Tobin, and Stephen M. Lanier: The Proto-oncogene SET Interacts with Muscarinic Receptors and Attenuates Receptor Signaling
J. Biol. Chem. 2006 281: 40310-40320. First Published on October 25, 2006; doi:10.1074/jbc.M603858200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ka-Wing Wong, Sina Mohammadi, and Ralph R. Isberg: Disruption of RhoGDI and RhoA Regulation by a Rac1 Specificity Switch Mutant
J. Biol. Chem. 2006 281: 40379-40388. First Published on October 29, 2006; doi:10.1074/jbc.M605387200 [Abstract] [Full Text] [PDF]

Gopal Sapkota, Marie Knockaert, Claudio Alarcón, Ermelinda Montalvo, Ali H. Brivanlou, and Joan Massagué: Dephosphorylation of the Linker Regions of Smad1 and Smad2/3 by Small C-terminal Domain Phosphatases Has Distinct Outcomes for Bone Morphogenetic Protein and Transforming Growth Factor- $beta$ Pathways
J. Biol. Chem. 2006 281: 40412-40419. First Published on November 2, 2006; doi:10.1074/jbc.M610172200 [Abstract] [Full Text] [PDF]

David N. Criddle, Stuart Gillies, Heidi K. Baumgartner-Wilson, Mohammed Jaffar, Edwin C. Chinje, Sarah Passmore, Michael Chvanov, Stephanie Barrow, Oleg V. Gerasimenko, Alexei V. Tepikin, Robert Sutton, and Ole H. Petersen: Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells
J. Biol. Chem. 2006 281: 40485-40492. First Published on November 6, 2006; doi:10.1074/jbc.M607704200 [Abstract] [Full Text] [PDF]

Martijn Kedde, Carlos le Sage, Anja Duursma, Eitan Zlotorynski, Bart van Leeuwen, Wouter Nijkamp, Roderick Beijersbergen, and Reuven Agami: Telomerase-independent Regulation of ATR by Human Telomerase RNA
J. Biol. Chem. 2006 281: 40503-40514. First Published on November 10, 2006; doi:10.1074/jbc.M607676200 [Abstract] [Full Text] [PDF] [Supplemental Data] [Summary]

Additions and Corrections:

David J. Adams, Geoffrey A. Head, M. Andrea Markus, Frank J. Lovicu, Louise van der Weyden, Frank Köntgen, Mark J. Arends, Sathia Thiru, Dmitry N. Mayorov, and Brian J. Morris: Renin enhancer is critical for control of renin gene expression and cardiovascular function. VOLUME 281 (2006) PAGES 31753-31761
J. Biol. Chem. 2006 281: 40527. [Full Text] [PDF]

Benu Brata Das, Nilkantha Sen, Somdeb Bose Dasgupta, Agneyo Ganguly, and Hemanta K. Majumder: N-terminal region of the large subunit of Leishmania donovani bisubunit topoisomerase I is involved in DNA relaxation and interaction with the smaller subunit. VOLUME 280 (2005) PAGES 16335-16344
J. Biol. Chem. 2006 281: 40528. [Full Text] [PDF]