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The conserved N-terminal (dark blue) region of one Shh molecule (light blue) makes extensive crystal contacts with another Shh molecule (green). Mutating amino acids important for these intermolecular interactions affect the ability of Shh to form its multimeric morphogenic form. The figure was created using the program PyMOL, version 0.98. For details see the article by Goetz et al., pages 4087–4093.

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