JBC -- Table of Contents (Feb 17 2006, 281, (7))

Ideal method for primary cell transfection

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Jian Hu and Yue Xiong: An Evolutionarily Conserved Function of Proliferating Cell Nuclear Antigen for Cdt1 Degradation by the Cul4-Ddb1 Ubiquitin Ligase in Response to DNA Damage
J. Biol. Chem. 2006 281: 3753-3756. First Published on January 3, 2006; doi:10.1074/jbc.C500464200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, and Recombination:

Jinshui Fan, Yoshihiro Matsumoto, and David M. Wilson, III: Nucleotide Sequence and DNA Secondary Structure, as Well as Replication Protein A, Modulate the Single-stranded Abasic Endonuclease Activity of APE1
J. Biol. Chem. 2006 281: 3889-3898. First Published on December 14, 2005; doi:10.1074/jbc.M511004200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jia-Lin Ma, Soo-Jung Lee, Jimmy K. Duong, and David F. Stern: Activation of the Checkpoint Kinase Rad53 by the Phosphatidyl Inositol Kinase-like Kinase Mec1
J. Biol. Chem. 2006 281: 3954-3963. First Published on December 19, 2005; doi:10.1074/jbc.M507508200 [Abstract] [Full Text] [PDF]

Aiping Chen, Irene T. Weber, Robert W. Harrison, and Jonathan Leis: Identification of Amino Acids in HIV-1 and Avian Sarcoma Virus Integrase Subsites Required for Specific Recognition of the Long Terminal Repeat Ends
J. Biol. Chem. 2006 281: 4173-4182. First Published on November 18, 2005; doi:10.1074/jbc.M510628200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Masakazu Kobayashi, Francis Figaroa, Nico Meeuwenoord, Lars E. T. Jansen, and Gregg Siegal: Characterization of the DNA Binding and Structural Properties of the BRCT Region of Human Replication Factor C p140 Subunit
J. Biol. Chem. 2006 281: 4308-4317. First Published on December 16, 2005; doi:10.1074/jbc.M511090200 [Abstract] [Full Text] [PDF]

Ranga N. Venkatesan, Jessica J. Hsu, Nicole A. Lawrence, Bradley D. Preston, and Lawrence A. Loeb: Mutator Phenotypes Caused by Substitution at a Conserved Motif A Residue in Eukaryotic DNA Polymerase ${delta}$
J. Biol. Chem. 2006 281: 4486-4494. First Published on December 12, 2005; doi:10.1074/jbc.M510245200 [Abstract] [Full Text] [PDF]

Genes: Structure and Regulation:

Yoshihiko Ohyama, Steve Meaney, Maura Heverin, Lena Ekström, Anat Brafman, Millicent Shafir, Ulla Andersson, Maria Olin, Gösta Eggertsen, Ulf Diczfalusy, Elena Feinstein, and Ingemar Björkhem: Studies on the Transcriptional Regulation of Cholesterol 24-Hydroxylase (CYP46A1): MARKED INSENSITIVITY TOWARD DIFFERENT REGULATORY AXES
J. Biol. Chem. 2006 281: 3810-3820. First Published on November 30, 2005; doi:10.1074/jbc.M505179200 [Abstract] [Full Text] [PDF]

Naoya Hashikawa, Yu Mizukami, Hiromi Imazu, and Hiroshi Sakurai: Mutated Yeast Heat Shock Transcription Factor Activates Transcription Independently of Hyperphosphorylation
J. Biol. Chem. 2006 281: 3936-3942. First Published on December 17, 2005; doi:10.1074/jbc.M510827200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Huibin Tang, Matthew B. Veldman, and Daniel Goldman: Characterization of a Muscle-specific Enhancer in Human MuSK Promoter Reveals the Essential Role of Myogenin in Controlling Activity-dependent Gene Regulation
J. Biol. Chem. 2006 281: 3943-3953. First Published on December 18, 2005; doi:10.1074/jbc.M511317200 [Abstract] [Full Text] [PDF]

Qun Yu, Joseph Sandmeier, Hengping Xu, Yanfei Zou, and Xin Bi: Mechanism of the Long Range Anti-silencing Function of Targeted Histone Acetyltransferases in Yeast
J. Biol. Chem. 2006 281: 3980-3988. First Published on December 19, 2005; doi:10.1074/jbc.M510140200 [Abstract] [Full Text] [PDF]

Zhe Zheng, Changmeng Cai, Josephat Omwancha, Shao-Yong Chen, Timour Baslan, and Lirim Shemshedini: SUMO-3 Enhances Androgen Receptor Transcriptional Activity through a Sumoylation-independent Mechanism in Prostate Cancer Cells
J. Biol. Chem. 2006 281: 4002-4012. First Published on December 15, 2005; doi:10.1074/jbc.M509260200 [Abstract] [Full Text] [PDF]

Jeffrey S. Huo, Richard C. McEachin, Tracy Xiao Cui, Nisha K. Duggal, Tsonwin Hai, David J. States, and Jessica Schwartz: Profiles of Growth Hormone (GH)-regulated Genes Reveal Time-dependent Responses and Identify a Mechanism for Regulation of Activating Transcription Factor 3 By GH
J. Biol. Chem. 2006 281: 4132-4141. First Published on December 1, 2005; doi:10.1074/jbc.M508492200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ling-Jun Zhao, T. Subramanian, Yun Zhou, and G. Chinnadurai: Acetylation by p300 Regulates Nuclear Localization and Function of the Transcriptional Corepressor CtBP2
J. Biol. Chem. 2006 281: 4183-4189. First Published on December 14, 2005; doi:10.1074/jbc.M509051200 [Abstract] [Full Text] [PDF]

Chris J. C. van Oevelen, Hetty A. A. M. van Teeffelen, Folkert J. van Werven, and H. Th. Marc Timmers: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) Recruitment and Chromatin Remodeling Activities on the HXT2 and HXT4 Promoters
J. Biol. Chem. 2006 281: 4523-4531. First Published on December 20, 2005; doi:10.1074/jbc.M509330200 [Abstract] [Full Text] [PDF] [Supplemental Data]

RNA: Structure, Metabolism, and Catalysis:

Hua Yan, Neela Zareen, and Louis Levinger: Naturally Occurring Mutations in Human Mitochondrial Pre-tRNA^Ser(UCN) Can Affect the Transfer Ribonuclease Z Cleavage Site, Processing Kinetics, and Substrate Secondary Structure
J. Biol. Chem. 2006 281: 3926-3935. First Published on December 16, 2005; doi:10.1074/jbc.M509822200 [Abstract] [Full Text] [PDF]

Nikolaos A. A. Balatsos, Per Nilsson, Catherine Mazza, Stephen Cusack, and Anders Virtanen: Inhibition of mRNA Deadenylation by the Nuclear Cap Binding Complex (CBC)
J. Biol. Chem. 2006 281: 4517-4522. First Published on November 28, 2005; doi:10.1074/jbc.M508590200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Protein Synthesis, Post-Translation Modification, and Degradation:

Riccardo Sgarra, Jaeho Lee, Michela A. Tessari, Sandro Altamura, Barbara Spolaore, Vincenzo Giancotti, Mark T. Bedford, and Guidalberto Manfioletti: The AT-hook of the Chromatin Architectural Transcription Factor High Mobility Group A1a Is Arginine-methylated by Protein Arginine Methyltransferase 6
J. Biol. Chem. 2006 281: 3764-3772. First Published on November 16, 2005; doi:10.1074/jbc.M510231200 [Abstract] [Full Text] [PDF]

Michael S. Mitchell, József Tözsér, Gerald Princler, Patricia A. Lloyd, Ashleigh Auth, and David Derse: Synthesis, Processing, and Composition of the Virion-associated HTLV-1 Reverse Transcriptase
J. Biol. Chem. 2006 281: 3964-3971. First Published on December 19, 2005; doi:10.1074/jbc.M507660200 [Abstract] [Full Text] [PDF]

Weiguo Zou and Dong-Er Zhang: The Interferon-inducible Ubiquitin-protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase
J. Biol. Chem. 2006 281: 3989-3994. First Published on December 13, 2005; doi:10.1074/jbc.M510787200 [Abstract] [Full Text] [PDF]

Yoshihiro Yamaguchi, Yumiko Takatsuka, Senya Matsufuji, Yasuko Murakami, and Yoshiyuki Kamio: Characterization of a Counterpart to Mammalian Ornithine Decarboxylase Antizyme in Prokaryotes
J. Biol. Chem. 2006 281: 3995-4001. First Published on December 14, 2005; doi:10.1074/jbc.M507545200 [Abstract] [Full Text] [PDF]

Simone Radtke, Angela Jörissen, Hildegard Schmitz-Van de Leur, Peter C. Heinrich, and Iris Behrmann: Three Dileucine-like Motifs within the Interbox1/2 Region of the Human Oncostatin M Receptor Prevent Efficient Surface Expression in the Absence of an Associated Janus Kinase
J. Biol. Chem. 2006 281: 4024-4034. First Published on November 11, 2005; doi:10.1074/jbc.M511779200 [Abstract] [Full Text] [PDF]

Jun-ichi Iwata, Junji Ezaki, Masaaki Komatsu, Sadaki Yokota, Takashi Ueno, Isei Tanida, Tomoki Chiba, Keiji Tanaka, and Eiki Kominami: Excess Peroxisomes Are Degraded by Autophagic Machinery in Mammals
J. Biol. Chem. 2006 281: 4035-4041. First Published on December 6, 2005; doi:10.1074/jbc.M512283200 [Abstract] [Full Text] [PDF]

Akihide Ryo, Takashi Togo, Toshiki Nakai, Akiko Hirai, Mayuko Nishi, Akira Yamaguchi, Kyoko Suzuki, Yoshio Hirayasu, Hideki Kobayashi, Kilian Perrem, Yih-Cherng Liou, and Ichiro Aoki: Prolyl-isomerase Pin1 Accumulates in Lewy Bodies of Parkinson Disease and Facilitates Formation of ${alpha}$ -Synuclein Inclusions
J. Biol. Chem. 2006 281: 4117-4125. First Published on December 19, 2005; doi:10.1074/jbc.M507026200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Matthew S. Macauley, Wesley J. Errington, Manuela Schärpf, Cameron D. Mackereth, Adam G. Blaszczak, Barbara J. Graves, and Lawrence P. McIntosh: Beads-on-a-String, Characterization of Ets-1 Sumoylated within Its Flexible N-terminal Sequence
J. Biol. Chem. 2006 281: 4164-4172. First Published on November 29, 2005; doi:10.1074/jbc.M510488200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Zhiliang Xie, Katherine I. O'Rourke, Zhiqian Dong, Allen L. Jenny, Julie A. Langenberg, Ermias D. Belay, Lawrence B. Schonberger, Robert B. Petersen, Wenquan Zou, Qingzhong Kong, Pierluigi Gambetti, and Shu G. Chen: Chronic Wasting Disease of Elk and Deer and Creutzfeldt-Jakob Disease: COMPARATIVE ANALYSIS OF THE SCRAPIE PRION PROTEIN
J. Biol. Chem. 2006 281: 4199-4206. First Published on December 7, 2005; doi:10.1074/jbc.M509052200 [Abstract] [Full Text] [PDF]

Christian Lindermayr, Gerhard Saalbach, Günther Bahnweg, and Jörg Durner: Differential Inhibition of Arabidopsis Methionine Adenosyltransferases by Protein S-Nitrosylation
J. Biol. Chem. 2006 281: 4285-4291. First Published on December 19, 2005; doi:10.1074/jbc.M511635200 [Abstract] [Full Text] [PDF]

Anahita Dastur, Sylvie Beaudenon, Melissa Kelley, Robert M. Krug, and Jon M. Huibregtse: Herc5, an Interferon-induced HECT E3 Enzyme, Is Required for Conjugation of ISG15 in Human Cells
J. Biol. Chem. 2006 281: 4334-4338. First Published on December 28, 2005; doi:10.1074/jbc.M512830200 [Abstract] [Full Text] [PDF]

Serge Grégoire, Annie M. Tremblay, Lin Xiao, Qian Yang, Kewei Ma, Jianyun Nie, Zixu Mao, Zhenguo Wu, Vincent Giguère, and Xiang-Jiao Yang: Control of MEF2 Transcriptional Activity by Coordinated Phosphorylation and Sumoylation
J. Biol. Chem. 2006 281: 4423-4433. First Published on December 15, 2005; doi:10.1074/jbc.M509471200 [Abstract] [Full Text] [PDF]

Lamine Bouakaz, Elli Bouakaz, Emanuel J. Murgola, Måns Ehrenberg, and Suparna Sanyal: The Role of Ribosomal Protein L11 in Class I Release Factor-mediated Translation Termination and Translational Accuracy
J. Biol. Chem. 2006 281: 4548-4556. First Published on December 21, 2005; doi:10.1074/jbc.M510433200 [Abstract] [Full Text] [PDF]

Protein Structure and Folding:

Gerard M. Gibbs, Martin J. Scanlon, James Swarbrick, Suzanne Curtis, Esther Gallant, Angela F. Dulhunty, and Moira K. O'Bryan: The Cysteine-rich Secretory Protein Domain of Tpx-1 Is Related to Ion Channel Toxins and Regulates Ryanodine Receptor Ca²⁺ Signaling
J. Biol. Chem. 2006 281: 4156-4163. First Published on December 9, 2005; doi:10.1074/jbc.M506849200 [Abstract] [Full Text] [PDF]

Benjamin Liou, Andrzej Kazimierczuk, Min Zhang, C. Ronald Scott, Rashmi S. Hegde, and Gregory A. Grabowski: Analyses of Variant Acid $beta$ -Glucosidases: EFFECTS OF GAUCHER DISEASE MUTATIONS
J. Biol. Chem. 2006 281: 4242-4253. First Published on November 17, 2005; doi:10.1074/jbc.M511110200 [Abstract] [Full Text] [PDF]

Hyung Ho Lee, Ji Young Yoon, Hyoun Sook Kim, Ji Yong Kang, Kyoung Hoon Kim, Do Jin Kim, Jun Yong Ha, Bunzo Mikami, Hye Jin Yoon, and Se Won Suh: Crystal Structure of a Metal Ion-bound IS200 Transposase
J. Biol. Chem. 2006 281: 4261-4266. First Published on December 11, 2005; doi:10.1074/jbc.M511567200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Nobutaka Shimizu, Yasushi Imamoto, Miki Harigai, Hironari Kamikubo, Yoichi Yamazaki, and Mikio Kataoka: pH-dependent Equilibrium between Long Lived Near-UV Intermediates of Photoactive Yellow Protein
J. Biol. Chem. 2006 281: 4318-4325. First Published on December 20, 2005; doi:10.1074/jbc.M506403200 [Abstract] [Full Text] [PDF]

Jacqueline L. S. Milne, Xiongwu Wu, Mario J. Borgnia, Jeffrey S. Lengyel, Bernard R. Brooks, Dan Shi, Richard N. Perham, and Sriram Subramaniam: Molecular Structure of a 9-MDa Icosahedral Pyruvate Dehydrogenase Subcomplex Containing the E2 and E3 Enzymes Using Cryoelectron Microscopy
J. Biol. Chem. 2006 281: 4364-4370. First Published on November 23, 2005; doi:10.1074/jbc.M504363200 [Abstract] [Full Text] [PDF]

Lina De Smet, Savvas N. Savvides, Ellen Van Horen, Graham Pettigrew, and Jozef J. Van Beeumen: Structural and Mutagenesis Studies on the Cytochrome c Peroxidase from Rhodobacter capsulatus Provide New Insights into Structure-Function Relationships of Bacterial Di-heme Peroxidases
J. Biol. Chem. 2006 281: 4371-4379. First Published on November 28, 2005; doi:10.1074/jbc.M509582200 [Abstract] [Full Text] [PDF]

Fanny Boissier, Fabienne Bardou, Valérie Guillet, Sandrine Uttenweiler-Joseph, Mamadou Daffé, Annaïk Quémard, and Lionel Mourey: Further Insight into S-Adenosylmethionine-dependent Methyltransferases: STRUCTURAL CHARACTERIZATION OF Hma, AN ENZYME ESSENTIAL FOR THE BIOSYNTHESIS OF OXYGENATED MYCOLIC ACIDS IN MYCOBACTERIUM TUBERCULOSIS
J. Biol. Chem. 2006 281: 4434-4445. First Published on December 15, 2005; doi:10.1074/jbc.M510250200 [Abstract] [Full Text] [PDF]

Gen Matsumoto, Soojin Kim, and Richard I. Morimoto: Huntingtin and Mutant SOD1 Form Aggregate Structures with Distinct Molecular Properties in Human Cells
J. Biol. Chem. 2006 281: 4477-4485. First Published on December 21, 2005; doi:10.1074/jbc.M509201200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Enzyme Catalysis and Regulation:

Klaus Klumpp, Vincent Lévêque, Sophie Le Pogam, Han Ma, Wen-Rong Jiang, Hyunsoon Kang, Caroline Granycome, Margaret Singer, Carl Laxton, Julie Qi Hang, Keshab Sarma, David B. Smith, Dieter Heindl, Chris J. Hobbs, John H. Merrett, Julian Symons, Nick Cammack, Joseph A. Martin, Rene Devos, and Isabel Nájera: The Novel Nucleoside Analog R1479 (4'-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture
J. Biol. Chem. 2006 281: 3793-3799. First Published on November 29, 2005; doi:10.1074/jbc.M510195200 [Abstract] [Full Text] [PDF]

Tae-Jin Oh, Jaiyanth Daniel, Hwa-Jung Kim, Tatiana D. Sirakova, and Pappachan E. Kolattukudy: Identification and Characterization of Rv3281 as a Novel Subunit of a Biotin-dependent Acyl-CoA Carboxylase in Mycobacterium tuberculosis H37Rv
J. Biol. Chem. 2006 281: 3899-3908. First Published on December 14, 2005; doi:10.1074/jbc.M511761200 [Abstract] [Full Text] [PDF]

Clifford A. Toleman, Andrew J. Paterson, and Jeffrey E. Kudlow: The Histone Acetyltransferase NCOAT Contains a Zinc Finger-like Motif Involved in Substrate Recognition
J. Biol. Chem. 2006 281: 3918-3925. First Published on December 15, 2005; doi:10.1074/jbc.M510485200 [Abstract] [Full Text] [PDF]

Jing Wu and Ronald W. Woodard: New Insights into the Evolutionary Links Relating to the 3-Deoxy-D-arabino-heptulosonate 7-Phosphate Synthase Subfamilies
J. Biol. Chem. 2006 281: 4042-4048. First Published on December 9, 2005; doi:10.1074/jbc.M512223200 [Abstract] [Full Text] [PDF]

Mayumi Nakanishi-Matsui, Sachiko Kashiwagi, Hiroyuki Hosokawa, Daniel J. Cipriano, Stanley D. Dunn, Yoh Wada, and Masamitsu Futai: Stochastic High-speed Rotation of Escherichia coli ATP Synthase F₁ Sector: THE ${epsilon}$ SUBUNIT-SENSITIVE ROTATION
J. Biol. Chem. 2006 281: 4126-4131. First Published on December 12, 2005; doi:10.1074/jbc.M510090200 [Abstract] [Full Text] [PDF]

Andrew G. Watts, Pablo Oppezzo, Stephen G. Withers, Pedro M. Alzari, and Alejandro Buschiazzo: Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase
J. Biol. Chem. 2006 281: 4149-4155. First Published on November 18, 2005; doi:10.1074/jbc.M510677200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Andrew T. Bauman, Erik T. Yukl, Katsiaryna Alkevich, Ashley L. McCormack, and Ninian J. Blackburn: The Hydrogen Peroxide Reactivity of Peptidylglycine Monooxygenase Supports a Cu(II)-Superoxo Catalytic Intermediate
J. Biol. Chem. 2006 281: 4190-4198. First Published on December 5, 2005; doi:10.1074/jbc.M511199200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Martha S. Field, Doletha M. E. Szebenyi, and Patrick J. Stover: Regulation of de Novo Purine Biosynthesis by Methenyltetrahydrofolate Synthetase in Neuroblastoma
J. Biol. Chem. 2006 281: 4215-4221. First Published on December 19, 2005; doi:10.1074/jbc.M510624200 [Abstract] [Full Text] [PDF]

Bjorn Vergauwen, Dirk De Vos, and Jozef J. Van Beeumen: Characterization of the Bifunctional ${gamma}$ -Glutamate-cysteine Ligase/Glutathione Synthetase (GshF) of Pasteurella multocida
J. Biol. Chem. 2006 281: 4380-4394. First Published on December 8, 2005; doi:10.1074/jbc.M509517200 [Abstract] [Full Text] [PDF]

Stéphane Mouilleron, Marie-Ange Badet-Denisot, and Béatrice Golinelli-Pimpaneau: Glutamine Binding Opens the Ammonia Channel and Activates Glucosamine-6P Synthase
J. Biol. Chem. 2006 281: 4404-4412. First Published on December 9, 2005; doi:10.1074/jbc.M511689200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Eiji Takahashi and Colin A. Wraight: Small Weak Acids Reactivate Proton Transfer in Reaction Centers from Rhodobacter sphaeroides Mutated at Asp^L210 and Asp^M17
J. Biol. Chem. 2006 281: 4413-4422. First Published on December 14, 2005; doi:10.1074/jbc.M511359200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Glycobiology and Extracellular Matrices:

Nicolas Raynal, Samir W. Hamaia, Pia R.-M. Siljander, Ben Maddox, Anthony R. Peachey, Rafael Fernandez, Loraine J. Foley, David A. Slatter, Gavin E. Jarvis, and Richard W. Farndale: Use of Synthetic Peptides to Locate Novel Integrin ${alpha}$ ₂ $beta$ ₁-binding Motifs in Human Collagen III
J. Biol. Chem. 2006 281: 3821-3831. First Published on December 2, 2005; doi:10.1074/jbc.M509818200 [Abstract] [Full Text] [PDF]

Michiyo Okamoto, Takehiko Yoko-o, Mariko Umemura, Ken-ichi Nakayama, and Yoshifumi Jigami: Glycosylphosphatidylinositol-anchored Proteins Are Required for the Transport of Detergent-resistant Microdomain-associated Membrane Proteins Tat2p and Fur4p
J. Biol. Chem. 2006 281: 4013-4023. First Published on December 15, 2005; doi:10.1074/jbc.M504684200 [Abstract] [Full Text] [PDF]

Lipids and Lipoproteins:

Mark G. Waugh, Shane Minogue, Dipti Chotai, Fedor Berditchevski, and J. Justin Hsuan: Lipid and Peptide Control of Phosphatidylinositol 4-Kinase II ${alpha}$ Activity on Golgi-endosomal Rafts
J. Biol. Chem. 2006 281: 3757-3763. First Published on October 25, 2005; doi:10.1074/jbc.M506527200 [Abstract] [Full Text] [PDF]

Chirajyoti Deb, Jaiyanth Daniel, Tatiana D. Sirakova, Bassam Abomoelak, Vinod S. Dubey, and Pappachan E. Kolattukudy: A Novel Lipase Belonging to the Hormone-sensitive Lipase Family Induced under Starvation to Utilize Stored Triacylglycerol in Mycobacterium tuberculosis
J. Biol. Chem. 2006 281: 3866-3875. First Published on December 13, 2005; doi:10.1074/jbc.M505556200 [Abstract] [Full Text] [PDF]

Barbara Karten, Robert B. Campenot, Dennis E. Vance, and Jean E. Vance: Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia
J. Biol. Chem. 2006 281: 4049-4057. First Published on December 13, 2005; doi:10.1074/jbc.M508915200 [Abstract] [Full Text] [PDF]

Yan Xie, Elizabeth P. Newberry, Stephen G. Young, Sylvie Robine, Robert L. Hamilton, Jinny S. Wong, Jianyang Luo, Susan Kennedy, and Nicholas O. Davidson: Compensatory Increase in Hepatic Lipogenesis in Mice with Conditional Intestine-specific Mttp Deficiency
J. Biol. Chem. 2006 281: 4075-4086. First Published on December 13, 2005; doi:10.1074/jbc.M510622200 [Abstract] [Full Text] [PDF]

Mingjiang Sun, Silvia C. Finnemann, Maria Febbraio, Lian Shan, Suresh P. Annangudi, Eugene A. Podrez, George Hoppe, Ruth Darrow, Daniel T. Organisciak, Robert G. Salomon, Roy L. Silverstein, and Stanley L. Hazen: Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium: A POTENTIAL MECHANISM FOR MODULATING OUTER SEGMENT PHAGOCYTOSIS UNDER OXIDANT STRESS CONDITIONS
J. Biol. Chem. 2006 281: 4222-4230. First Published on December 13, 2005; doi:10.1074/jbc.M509769200 [Abstract] [Full Text] [PDF]

Arturo Rosso, Antonina Balsamo, Roberto Gambino, Patrizia Dentelli, Rita Falcioni, Maurizio Cassader, Luigi Pegoraro, Gianfranco Pagano, and Maria Felice Brizzi: p53 Mediates the Accelerated Onset of Senescence of Endothelial Progenitor Cells in Diabetes
J. Biol. Chem. 2006 281: 4339-4347. First Published on December 9, 2005; doi:10.1074/jbc.M509293200 [Abstract] [Full Text] [PDF]

Erik R. M. Eckhardt, Lei Cai, Shoba Shetty, Zhenze Zhao, Attila Szanto, Nancy R. Webb, and Deneys R. Van der Westhuyzen: High Density Lipoprotein Endocytosis by Scavenger Receptor SR-BII Is Clathrin-dependent and Requires a Carboxyl-terminal Dileucine Motif
J. Biol. Chem. 2006 281: 4348-4353. First Published on December 19, 2005; doi:10.1074/jbc.M513154200 [Abstract] [Full Text] [PDF]

Sofie M. G. Saerens, Kevin J. Verstrepen, Stijn D. M. Van Laere, Arnout R. D. Voet, Patrick Van Dijck, Freddy R. Delvaux, and Johan M. Thevelein: The Saccharomyces cerevisiae EHT1 and EEB1 Genes Encode Novel Enzymes with Medium-chain Fatty Acid Ethyl Ester Synthesis and Hydrolysis Capacity
J. Biol. Chem. 2006 281: 4446-4456. First Published on December 15, 2005; doi:10.1074/jbc.M512028200 [Abstract] [Full Text] [PDF]

Akio Kihara, Yoshihiro Anada, and Yasuyuki Igarashi: Mouse Sphingosine Kinase Isoforms SPHK1a and SPHK1b Differ in Enzymatic Traits Including Stability, Localization, Modification, and Oligomerization
J. Biol. Chem. 2006 281: 4532-4539. First Published on December 20, 2005; doi:10.1074/jbc.M510308200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Martin L. Daus, Heidi Landmesser, Andreas Schlosser, Peter Müller, Andreas Herrmann, and Erwin Schneider: ATP Induces Conformational Changes of Periplasmic Loop Regions of the Maltose ATP-binding Cassette Transporter
J. Biol. Chem. 2006 281: 3856-3865. First Published on December 12, 2005; doi:10.1074/jbc.M511953200 [Abstract] [Full Text] [PDF]

Dimitri Lavillette, Birke Bartosch, Delphine Nourrisson, Géraldine Verney, François-Loïc Cosset, François Penin, and Eve-Isabelle Pécheur: Hepatitis C Virus Glycoproteins Mediate Low pH-dependent Membrane Fusion with Liposomes
J. Biol. Chem. 2006 281: 3909-3917. First Published on December 15, 2005; doi:10.1074/jbc.M509747200 [Abstract] [Full Text] [PDF]

Gopal J. Babu, Poornima Bhupathy, Natalia N. Petrashevskaya, Honglan Wang, Sripriya Raman, Debra Wheeler, Ganapathy Jagatheesan, David Wieczorek, Arnold Schwartz, Paul M. L. Janssen, Mark T. Ziolo, and Muthu Periasamy: Targeted Overexpression of Sarcolipin in the Mouse Heart Decreases Sarcoplasmic Reticulum Calcium Transport and Cardiac Contractility
J. Biol. Chem. 2006 281: 3972-3979. First Published on December 19, 2005; doi:10.1074/jbc.M508998200 [Abstract] [Full Text] [PDF]

Christian H. Gross, Norzehan Abdul-Manan, John Fulghum, Judith Lippke, Xun Liu, Prakash Prabhakar, Debra Brennan, Melissa Swope Willis, Carlos Faerman, Patrick Connelly, Scott Raybuck, and Jonathan Moore: Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but Not ATP Hydrolysis
J. Biol. Chem. 2006 281: 4058-4068. First Published on December 16, 2005; doi:10.1074/jbc.M511113200 [Abstract] [Full Text] [PDF]

Qiuming Gong, Melanie A. Jones, and Zhengfeng Zhou: Mechanisms of Pharmacological Rescue of Trafficking-defective hERG Mutant Channels in Human Long QT Syndrome
J. Biol. Chem. 2006 281: 4069-4074. First Published on December 16, 2005; doi:10.1074/jbc.M511765200 [Abstract] [Full Text] [PDF]

Elzbieta Szczesna-Skorupa and Byron Kemper: BAP31 Is Involved in the Retention of Cytochrome P450 2C2 in the Endoplasmic Reticulum
J. Biol. Chem. 2006 281: 4142-4148. First Published on December 6, 2005; doi:10.1074/jbc.M509522200 [Abstract] [Full Text] [PDF]

Kenneth R. Hallows, Adam C. Fitch, Christine A. Richardson, Paul R. Reynolds, John P. Clancy, Pierre C. Dagher, Lee A. Witters, Jay K. Kolls, and Joseph M. Pilewski: Up-regulation of AMP-activated Kinase by Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Airway Epithelial Cells Mitigates Excessive Inflammation
J. Biol. Chem. 2006 281: 4231-4241. First Published on December 18, 2005; doi:10.1074/jbc.M511029200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Takahiro Kamimoto, Shisako Shoji, Tunda Hidvegi, Noboru Mizushima, Kyohei Umebayashi, David H. Perlmutter, and Tamotsu Yoshimori: Intracellular Inclusions Containing Mutant ${alpha}$ ₁-Antitrypsin Z Are Propagated in the Absence of Autophagic Activity
J. Biol. Chem. 2006 281: 4467-4476. First Published on December 19, 2005; doi:10.1074/jbc.M509409200 [Abstract] [Full Text] [PDF]

Akiko Joo Okumura, Kiyotaka Hatsuzawa, Taku Tamura, Hisao Nagaya, Kazuko Saeki, Fumihiko Okumura, Kenji Nagao, Mitsuo Nishikawa, Akihiko Yoshimura, and Ikuo Wada: Involvement of a Novel Q-SNARE, D12, in Quality Control of the Endomembrane System
J. Biol. Chem. 2006 281: 4495-4506. First Published on December 14, 2005; doi:10.1074/jbc.M509715200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Da-Wei Zhang, Gregory A. Graf, Robert D. Gerard, Jonathan C. Cohen, and Helen H. Hobbs: Functional Asymmetry of Nucleotide-binding Domains in ABCG5 and ABCG8
J. Biol. Chem. 2006 281: 4507-4516. First Published on December 12, 2005; doi:10.1074/jbc.M512277200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Jaisri R. Lingappa, Julia E. Dooher, Michael A. Newman, Patti K. Kiser, and Kevin C. Klein: Basic Residues in the Nucleocapsid Domain of Gag Are Required for Interaction of HIV-1 Gag with ABCE1 (HP68), a Cellular Protein Important for HIV-1 Capsid Assembly
J. Biol. Chem. 2006 281: 3773-3784. First Published on November 7, 2005; doi:10.1074/jbc.M507255200 [Abstract] [Full Text] [PDF]

Anna Parnis, Moran Rawet, Lior Regev, Batya Barkan, Miriam Rotman, Michal Gaitner, and Dan Cassel: Golgi Localization Determinants in ArfGAP1 and in New Tissue-specific ArfGAP1 Isoforms
J. Biol. Chem. 2006 281: 3785-3792. First Published on November 29, 2005; doi:10.1074/jbc.M508959200 [Abstract] [Full Text] [PDF]

Dian-Shi Wang, Jean-Marie Mangin, Gustave Moonen, Jean-Michel Rigo, and Pascal Legendre: Mechanisms for Picrotoxin Block of ${alpha}$ ₂ Homomeric Glycine Receptors
J. Biol. Chem. 2006 281: 3841-3855. First Published on December 12, 2005; doi:10.1074/jbc.M511022200 [Abstract] [Full Text] [PDF]

John A. Goetz, Samer Singh, Liza M. Suber, F. Jon Kull, and David J. Robbins: A Highly Conserved Amino-terminal Region of Sonic Hedgehog Is Required for the Formation of Its Freely Diffusible Multimeric Form
J. Biol. Chem. 2006 281: 4087-4093. First Published on December 9, 2005; doi:10.1074/jbc.M511427200 [Abstract] [Full Text] [PDF]

Keiko Haraguchi, Tomoatsu Hayashi, Takeshi Jimbo, Tadashi Yamamoto, and Tetsu Akiyama: Role of the Kinesin-2 Family Protein, KIF3, during Mitosis
J. Biol. Chem. 2006 281: 4094-4099. First Published on November 18, 2005; doi:10.1074/jbc.M507028200 [Abstract] [Full Text] [PDF]

Chunlin Cai, Hong Li, Claudio Rivera, and Kari Keinänen: Interaction between SAP97 and PSD-95, Two Maguk Proteins Involved in Synaptic Trafficking of AMPA Receptors
J. Biol. Chem. 2006 281: 4267-4273. First Published on December 6, 2005; doi:10.1074/jbc.M505886200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Edward B. Lee, Lewis Z. Leng, Bin Zhang, Linda Kwong, John Q. Trojanowski, Ted Abel, and Virginia M.-Y. Lee: Targeting Amyloid- $beta$ Peptide (A $beta$ ) Oligomers by Passive Immunization with a Conformation-selective Monoclonal Antibody Improves Learning and Memory in A $beta$ Precursor Protein (APP) Transgenic Mice
J. Biol. Chem. 2006 281: 4292-4299. First Published on December 16, 2005; doi:10.1074/jbc.M511018200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Bradley J. Wallar, Brittany N. Stropich, Jessica A. Schoenherr, Holly A. Holman, Susan M. Kitchen, and Arthur S. Alberts: The Basic Region of the Diaphanous-autoregulatory Domain (DAD) Is Required for Autoregulatory Interactions with the Diaphanous-related Formin Inhibitory Domain
J. Biol. Chem. 2006 281: 4300-4307. First Published on December 18, 2005; doi:10.1074/jbc.M510277200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Mechanisms Of Signal Transduction:

Jeffrey A. Knauf, Bin Ouyang, Erik S. Knudsen, Kenji Fukasawa, George Babcock, and James A. Fagin: Oncogenic RAS Induces Accelerated Transition through G₂/M and Promotes Defects in the G₂ DNA Damage and Mitotic Spindle Checkpoints
J. Biol. Chem. 2006 281: 3800-3809. First Published on November 29, 2005; doi:10.1074/jbc.M511690200 [Abstract] [Full Text] [PDF]

Lauren Brown and Samuel Benchimol: The Involvement of MAPK Signaling Pathways in Determining the Cellular Response to p53 Activation: CELL CYCLE ARREST OR APOPTOSIS
J. Biol. Chem. 2006 281: 3832-3840. First Published on December 5, 2005; doi:10.1074/jbc.M507951200 [Abstract] [Full Text] [PDF]

Davina Twiddy, Gerald M. Cohen, Marion MacFarlane, and Kelvin Cain: Caspase-7 Is Directly Activated by the $~$ 700-kDa Apoptosome Complex and Is Released as a Stable XIAP-Caspase-7 $~$ 200-kDa Complex
J. Biol. Chem. 2006 281: 3876-3888. First Published on December 13, 2005; doi:10.1074/jbc.M507393200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Marianela Masin, Daniel Kerschensteiner, Kerstin Dümke, Maria E. Rubio, and Florentina Soto: Fe65 Interacts with P2X₂ Subunits at Excitatory Synapses and Modulates Receptor Function
J. Biol. Chem. 2006 281: 4100-4108. First Published on December 5, 2005; doi:10.1074/jbc.M507735200 [Abstract] [Full Text] [PDF]

Steven Swift, Andrew J. Leger, Joyce Talavera, Lei Zhang, Andrew Bohm, and Athan Kuliopulos: Role of the PAR1 Receptor 8th Helix in Signaling: THE 7-8-1 RECEPTOR ACTIVATION MECHANISM
J. Biol. Chem. 2006 281: 4109-4116. First Published on December 13, 2005; doi:10.1074/jbc.M509525200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Zheng Yang, Bethany H. Cool, George M. Martin, and Qubai Hu: A Dominant Role for FE65 (APBB1) in Nuclear Signaling
J. Biol. Chem. 2006 281: 4207-4214. First Published on December 6, 2005; doi:10.1074/jbc.M508445200 [Abstract] [Full Text] [PDF]

Lijun Liu, Xi Song, Dandan He, Chandrasekhar Komma, Akiko Kita, Joseph V. Virbasius, Guiqing Huang, Henry D. Bellamy, Kunio Miki, Michael P. Czech, and G. Wayne Zhou: Crystal Structure of the C2 Domain of Class II Phosphatidylinositide 3-Kinase C2 ${alpha}$
J. Biol. Chem. 2006 281: 4254-4260. First Published on December 7, 2005; doi:10.1074/jbc.M510791200 [Abstract] [Full Text] [PDF]

Tommaso Fellin, Tullio Pozzan, and Giorgio Carmignoto: Purinergic Receptors Mediate Two Distinct Glutamate Release Pathways in Hippocampal Astrocytes
J. Biol. Chem. 2006 281: 4274-4284. First Published on December 6, 2005; doi:10.1074/jbc.M510679200 [Abstract] [Full Text] [PDF]

Hiroyuki Kaneki, Ruolin Guo, Di Chen, Zhenqiang Yao, Edward M. Schwarz, Ying E. Zhang, Brendan F. Boyce, and Lianping Xing: Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts
J. Biol. Chem. 2006 281: 4326-4333. First Published on December 22, 2005; doi:10.1074/jbc.M509430200 [Abstract] [Full Text] [PDF]

Laura Stanasila, Liliane Abuin, Dario Diviani, and Susanna Cotecchia: Ezrin Directly Interacts with the ${alpha}$ 1b-Adrenergic Receptor and Plays a Role in Receptor Recycling
J. Biol. Chem. 2006 281: 4354-4363. First Published on December 13, 2005; doi:10.1074/jbc.M511989200 [Abstract] [Full Text] [PDF]

Suresh K. Rayala, Petra den Hollander, Seetharaman Balasenthil, Poonam R. Molli, Andrew J. Bean, Ratna K. Vadlamudi, Rui-An Wang, and Rakesh Kumar: Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Interacts with PELP1 and Activates MAPK
J. Biol. Chem. 2006 281: 4395-4403. First Published on December 12, 2005; doi:10.1074/jbc.M510368200 [Abstract] [Full Text] [PDF]

Lijun Xu and Xingming Deng: Protein Kinase C ${iota}$ Promotes Nicotine-induced Migration and Invasion of Cancer Cells via Phosphorylation of µ- and m-Calpains
J. Biol. Chem. 2006 281: 4457-4466. First Published on December 16, 2005; doi:10.1074/jbc.M510721200 [Abstract] [Full Text] [PDF]

Zhanguo Gao, Qing He, Bailu Peng, Paul J. Chiao, and Jianping Ye: Regulation of Nuclear Translocation of HDAC3 by I ${kappa}$ B ${alpha}$ Is Required for Tumor Necrosis Factor Inhibition of Peroxisome Proliferator-activated Receptor ${gamma}$ Function
J. Biol. Chem. 2006 281: 4540-4547. First Published on December 21, 2005; doi:10.1074/jbc.M507784200 [Abstract] [Full Text] [PDF]