On The Cover: Application of a high throughput FRAC (functional recovery after chemobleaching) assay has been used to profile compounds with potential cardiotoxicity. Celastrol (pictured), a natural compound, inhibits both Kir2.1 and hERG potassium channels critical for heart function. For details see the article by Sun et al., pages 5877–5884. (Image prepared by Brian Coblitz and Amy Phifer.)

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