On The Cover: The image shows β-amyloid (Aβ) antibody 6E10 (green) endocytosed by a Tg2576-cultured primary neuron. Aβ antibody uptake correlated with a progressive decrease in intraneuronal Aβ42 (red). Aβ antibody 6E10 was detected with anti-mouse fluorescent Alexa-488 secondary antibody. Aβ42 was detected using an Aβ42 antibody (C terminus-specific) with an anti-rabbit Alexa-546 secondary antibody. For details see the article by Tampellini et al., pages 18895–18906.
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