On The Cover: Development of a technique for intranuclear delivery of therapeutic macromolecules will facilitate an expansion in molecular therapies for human diseases but requires identification of pathways capable of mediating intranuclear macromolecular transport. In this issue, Hansen et al. (pages 20790–20793) present the first evidence of intranuclear protein transduction through a nucleoside salvage pathway. Image created by www.christianchang.com.

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