On The Cover: Direct observation on an extremely potent HIV-neutralizing protein in complex with native viral gp120 (purple), using cryoelectron tomography. This engineered protein contains human CD4 (blue), IgG (red), and IgA (yellow) domains and appears to neutralize viral infectivity by cross-linking gp120 spikes, as shown here, and by inducing viral rupture. For details see the article by Bennett et al., pages 27754–27759.

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