On The Cover: Transgenic mice that overexpress PEPCK-C in their skeletal muscle (PEPCK-C^mus mice) were hyperactive and able to run farther and faster than controls; these mice also have up to 10 times the amount of triglyceride in their skeletal muscle. Clockwise from the top: hematoxylin and eosin (H&E) staining of skeletal muscle showing lipid inclusions in the muscle of the PEPCK-C^mus mice; a graphical demonstration of the continued use of fatty acids by the PEPCK-C^mus mice during exercise; a PEPCK-C^mus mouse and two offspring used for exercise data; the mouse treadmill on which transgenic and control mice were exercised. Cover design was by Yacoub Baghdy. For details see the article by Hakimi et al., pages 32844–32855.

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