On The Cover: How to activate a tertiary amine? Nature has put an asparagine residue instead of an acid around the contact point of the protein and the N5 methyltetrahydrofolate. In the article by Doukov et al., pages 6609–6618, the authors suggest that an extended hydrogen bond network is responsible for the protonation of N5 of the folate and the asparagine 199 plays an important role in stabilizing a transition state or high energy intermediate for methyl transfer.

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