About the Cover
On The Cover: Kv1 channel (magenta) assembles with cytosolic Kvβ subunit (green) to form a stable (Kv1)4-(Kvβ)4 complex (Protein Data Bank entry 2A79). Each Kvβ has an NADPH cofactor (orange) and an N terminus (blue) that closes the channel by the N-type inactivation mechanism. For clarity only two N termini are shown. Oxidation of the NADPH suppresses inactivation, thus coupling metabolic redox state to cell excitability. For details see the article by Pan et al., pages 8634–8642.
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Copyright © 2008 by the American Society for Biochemistry and Molecular Biology.
