JBC -- Table of Contents (May 30 2008, 283, (22))

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Reflections:

John H. Exton: In Search of the Message
J. Biol. Chem. 2008 283: 14901-14909. First Published on March 31, 2008; doi:10.1074/jbc.X800001200 [Full Text] [PDF]

Accelerated Publications:

Manav Korpal, Esther S. Lee, Guohong Hu, and Yibin Kang: The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2
J. Biol. Chem. 2008 283: 14910-14914. First Published on April 14, 2008; doi:10.1074/jbc.C800074200 [Abstract] [Full Text] [PDF]

DNA: Replication, Repair, Recombination, and Chromosome Dynamics:

James J. Pesavento, Courtney R. Bullock, Richard D. LeDuc, Craig A. Mizzen, and Neil L. Kelleher: Combinatorial Modification of Human Histone H4 Quantitated by Two-dimensional Liquid Chromatography Coupled with Top Down Mass Spectrometry
J. Biol. Chem. 2008 283: 14927-14937. First Published on April 1, 2008; doi:10.1074/jbc.M709796200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jason D. Fowler, Jessica A. Brown, Kenneth A. Johnson, and Zucai Suo: Kinetic Investigation of the Inhibitory Effect of Gemcitabine on DNA Polymerization Catalyzed by Human Mitochondrial DNA Polymerase
J. Biol. Chem. 2008 283: 15339-15348. First Published on March 31, 2008; doi:10.1074/jbc.M800310200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Dexi Chen, Zhiyong Yu, Zhiyi Zhu, and Charles D. Lopez: E2F1 Regulates the Base Excision Repair Gene XRCC1 and Promotes DNA Repair
J. Biol. Chem. 2008 283: 15381-15389. First Published on March 17, 2008; doi:10.1074/jbc.M710296200 [Abstract] [Full Text] [PDF]

Transcription, Chromatin, and Epigenetics:

Da-Wei Lin, Il-Chi Chang, Alan Tseng, Meng-Ling Wu, Chung-Huang Chen, Cassandra A. Patenaude, Matthew D. Layne, and Shaw-Fang Yet: Transforming Growth Factor β Up-regulates Cysteine-rich Protein 2 in Vascular Smooth Muscle Cells via Activating Transcription Factor 2
J. Biol. Chem. 2008 283: 15003-15014. First Published on April 3, 2008; doi:10.1074/jbc.M801621200 [Abstract] [Full Text] [PDF]

Charlotte Labalette, Yann Nouët, Joëlle Sobczak-Thepot, Carolina Armengol, Florence Levillayer, Marie-Claude Gendron, Claire-Angélique Renard, Béatrice Regnault, Ju Chen, Marie-Annick Buendia, and Yu Wei: The LIM-only Protein FHL2 Regulates Cyclin D1 Expression and Cell Proliferation
J. Biol. Chem. 2008 283: 15201-15208. First Published on March 31, 2008; doi:10.1074/jbc.M800708200 [Abstract] [Full Text] [PDF]

Cheng-Yuan Kao, Christy Kim, Fei Huang, and Reen Wu: Requirements for Two Proximal NF- ${kappa}$ B Binding Sites and I ${kappa}$ B- ${zeta}$ in IL-17A-induced Human β-Defensin 2 Expression by Conducting Airway Epithelium
J. Biol. Chem. 2008 283: 15309-15318. First Published on March 24, 2008; doi:10.1074/jbc.M708289200 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE

Protein Synthesis, Post-Translational Modification, and Degradation:

Mitsumi Arito, Taro Horiba, Satoshi Hachimura, Jun Inoue, and Ryuichiro Sato: Growth Factor-induced Phosphorylation of Sterol Regulatory Element-binding Proteins Inhibits Sumoylation, Thereby Stimulating the Expression of Their Target Genes, Low Density Lipoprotein Uptake, and Lipid Synthesis
J. Biol. Chem. 2008 283: 15224-15231. First Published on April 9, 2008; doi:10.1074/jbc.M800910200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Matthew J. Rardin, Sandra E. Wiley, Anne N. Murphy, David J. Pagliarini, and Jack E. Dixon: Dual Specificity Phosphatases 18 and 21 Target to Opposing Sides of the Mitochondrial Inner Membrane
J. Biol. Chem. 2008 283: 15440-15450. First Published on April 2, 2008; doi:10.1074/jbc.M709547200 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE

Protein Structure and Folding:

Jing-He Huang, Zhi Qi, Fan Wu, Leszek Kotula, Shibo Jiang, and Ying-Hua Chen: Interaction of HIV-1 gp41 Core with NPF Motif in Epsin: IMPLICATION IN ENDOCYTOSIS OF HIV
J. Biol. Chem. 2008 283: 14994-15002. First Published on March 28, 2008; doi:10.1074/jbc.M800525200 [Abstract] [Full Text] [PDF]

Steen V. Petersen, Torsten Kristensen, Jane S. Petersen, Lasse Ramsgaard, Tim D. Oury, James D. Crapo, Niels C. Nielsen, and Jan J. Enghild: The Folding of Human Active and Inactive Extracellular Superoxide Dismutases Is an Intracellular Event
J. Biol. Chem. 2008 283: 15031-15036. First Published on April 2, 2008; doi:10.1074/jbc.M801548200 [Abstract] [Full Text] [PDF]

Shujian Cun, Hongyan Li, Ruiguang Ge, Marie C. M. Lin, and Hongzhe Sun: A Histidine-rich and Cysteine-rich Metal-binding Domain at the C Terminus of Heat Shock Protein A from Helicobacter pylori: IMPLICATION FOR NICKEL HOMEOSTASIS AND BISMUTH SUSCEPTIBILITY
J. Biol. Chem. 2008 283: 15142-15151. First Published on March 25, 2008; doi:10.1074/jbc.M800591200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ali Nasser Eddine, Jens P. von Kries, Mikhail V. Podust, Thulasi Warrier, Stefan H. E. Kaufmann, and Larissa M. Podust: X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 ${alpha}$ -Demethylase (CYP51)
J. Biol. Chem. 2008 283: 15152-15159. First Published on March 26, 2008; doi:10.1074/jbc.M801145200 [Abstract] [Full Text] [PDF] [Supplemental Data] [Summary]

Lior Cohen, Noa Lipstein, Izhar Karbat, Nitza Ilan, Nicolas Gilles, Roy Kahn, Dalia Gordon, and Michael Gurevitz: Miniaturization of Scorpion β-Toxins Uncovers a Putative Ancestral Surface of Interaction with Voltage-gated Sodium Channels
J. Biol. Chem. 2008 283: 15169-15176. First Published on March 13, 2008; doi:10.1074/jbc.M801229200 [Abstract] [Full Text] [PDF] [Summary]

Ilya M. Alexandrov, Aleksandra B. Vishnevskaya, Michael D. Ter-Avanesyan, and Vitaly V. Kushnirov: Appearance and Propagation of Polyglutamine-based Amyloids in Yeast: TYROSINE RESIDUES ENABLE POLYMER FRAGMENTATION
J. Biol. Chem. 2008 283: 15185-15192. First Published on April 1, 2008; doi:10.1074/jbc.M802071200 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE

Yi-Wei Chang, Yuh-Ju Sun, Chung Wang, and Chwan-Deng Hsiao: Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation
J. Biol. Chem. 2008 283: 15502-15511. First Published on April 8, 2008; doi:10.1074/jbc.M708992200 [Abstract] [Full Text] [PDF]

Enzyme Catalysis and Regulation:

Jeremy W. Chambers, Margaret T. Kearns, Meredith T. Morris, and James C. Morris: Assembly of Heterohexameric Trypanosome Hexokinases Reveals That Hexokinase 2 Is a Regulable Enzyme
J. Biol. Chem. 2008 283: 14963-14970. First Published on April 3, 2008; doi:10.1074/jbc.M802124200 [Abstract] [Full Text] [PDF]

Shuntaro Takahashi, Hisao Matsuno, Hiroyuki Furusawa, and Yoshio Okahata: Direct Monitoring of Allosteric Recognition of Type IIE Restriction Endonuclease EcoRII
J. Biol. Chem. 2008 283: 15023-15030. First Published on March 26, 2008; doi:10.1074/jbc.M800334200 [Abstract] [Full Text] [PDF]

Iraida G. Sharina, Filip Jelen, Elena P. Bogatenkova, Anthony Thomas, Emil Martin, and Ferid Murad: ${alpha}$ 1 Soluble Guanylyl Cyclase (sGC) Splice Forms as Potential Regulators of Human sGC Activity
J. Biol. Chem. 2008 283: 15104-15113. First Published on April 1, 2008; doi:10.1074/jbc.M710269200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ann-Gerd Thorsell, Camilla Persson, Nina Voevodskaya, Robert D. Busam, Martin Hammarström, Susanne Gräslund, Astrid Gräslund, and B. Martin Hallberg: Structural and Biophysical Characterization of Human myo-Inositol Oxygenase
J. Biol. Chem. 2008 283: 15209-15216. First Published on March 24, 2008; doi:10.1074/jbc.M800348200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Sujin Lee, Myung Hee Kim, Beom Sik Kang, Jeong-Sun Kim, Ghyung-Hwa Kim, Yeon-Gil Kim, and Kyung Jin Kim: Crystal Structure of Escherichia coli MazG, the Regulator of Nutritional Stress Response
J. Biol. Chem. 2008 283: 15232-15240. First Published on March 18, 2008; doi:10.1074/jbc.M800479200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Takaaki Daimon, Tomohiro Taguchi, Yan Meng, Susumu Katsuma, Kazuei Mita, and Toru Shimada: β-Fructofuranosidase Genes of the Silkworm, Bombyx mori: INSIGHTS INTO ENZYMATIC ADAPTATION OF B. MORI TO TOXIC ALKALOIDS IN MULBERRY LATEX
J. Biol. Chem. 2008 283: 15271-15279. First Published on April 8, 2008; doi:10.1074/jbc.M709350200 [Abstract] [Full Text] [PDF]

Christopher Bräsen, Marcel Schmidt, Joachim Grötzinger, and Peter Schönheit: Reaction Mechanism and Structural Model of ADP-forming Acetyl-CoA Synthetase from the Hyperthermophilic Archaeon Pyrococcus furiosus: EVIDENCE FOR A SECOND ACTIVE SITE HISTIDINE RESIDUE
J. Biol. Chem. 2008 283: 15409-15418. First Published on March 27, 2008; doi:10.1074/jbc.M710218200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Ekaterina Y. Shishova, Fanglei Yu, David J. Miller, Juan A. Faraldos, Yuxin Zhao, Robert M. Coates, Rudolf K. Allemann, David E. Cane, and David W. Christianson: X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis
J. Biol. Chem. 2008 283: 15431-15439. First Published on April 2, 2008; doi:10.1074/jbc.M800659200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Dana Schiefelbein, Itamar Goren, Beate Fisslthaler, Helmut Schmidt, Gerd Geisslinger, Josef Pfeilschifter, and Stefan Frank: Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses
J. Biol. Chem. 2008 283: 15479-15490. First Published on April 3, 2008; doi:10.1074/jbc.M709841200 [Abstract] [Full Text] [PDF]

Metabolism and Bioenergetics:

Kevin Rigby, Paul A. Cobine, Oleh Khalimonchuk, and Dennis R. Winge: Mapping the Functional Interaction of Sco1 and Cox2 in Cytochrome Oxidase Biogenesis
J. Biol. Chem. 2008 283: 15015-15022. First Published on April 7, 2008; doi:10.1074/jbc.M710072200 [Abstract] [Full Text] [PDF]

Itzhak Nissim, Oksana Horyn, Ilana Nissim, Yevgeny Daikhin, Suzanne L. Wehrli, and Marc Yudkoff: 3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis: PROTECTION BY AGMATINE
J. Biol. Chem. 2008 283: 15063-15071. First Published on March 28, 2008; doi:10.1074/jbc.M800163200 [Abstract] [Full Text] [PDF]

Aymerick Eudes, Gale G. Bozzo, Jeffrey C. Waller, Valeria Naponelli, Eng-Kiat Lim, Dianna J. Bowles, Jesse F. Gregory, III, and Andrew D. Hanson: Metabolism of the Folate Precursor p-Aminobenzoate in Plants: GLUCOSE ESTER FORMATION AND VACUOLAR STORAGE
J. Biol. Chem. 2008 283: 15451-15459. First Published on April 2, 2008; doi:10.1074/jbc.M709591200 [Abstract] [Full Text] [PDF]

Thomas M. Tomasiak, Elena Maklashina, Gary Cecchini, and Tina M. Iverson: A Threonine on the Active Site Loop Controls Transition State Formation in Escherichia coli Respiratory Complex II
J. Biol. Chem. 2008 283: 15460-15468. First Published on April 2, 2008; doi:10.1074/jbc.M801372200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Glycobiology and Extracellular Matrices:

Tomoyuki Kaneiwa, Shuhei Yamada, Shuji Mizumoto, Adriana M. Montaño, Shohei Mitani, and Kazuyuki Sugahara: Identification of a Novel Chondroitin Hydrolase in Caenorhabditis elegans
J. Biol. Chem. 2008 283: 14971-14979. First Published on April 4, 2008; doi:10.1074/jbc.M709236200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Svetlana V. Kyosseva, Edward N. Harris, and Paul H. Weigel: The Hyaluronan Receptor for Endocytosis Mediates Hyaluronan-dependent Signal Transduction via Extracellular Signal-regulated Kinases
J. Biol. Chem. 2008 283: 15047-15055. First Published on April 2, 2008; doi:10.1074/jbc.M709921200 [Abstract] [Full Text] [PDF]

Elodie Crublet, Jean-Pierre Andrieu, Romain R. Vivès, and Hugues Lortat-Jacob: The HIV-1 Envelope Glycoprotein gp120 Features Four Heparan Sulfate Binding Domains, Including the Co-receptor Binding Site
J. Biol. Chem. 2008 283: 15193-15200. First Published on March 31, 2008; doi:10.1074/jbc.M800066200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Lipids and Lipoproteins: Metabolism, Regulation, and Signaling:

Dong-Ju Shin and Timothy F. Osborne: Peroxisome Proliferator-activated Receptor- ${gamma}$ Coactivator-1 ${alpha}$ Activation of CYP7A1 during Food Restriction and Diabetes Is Still Inhibited by Small Heterodimer Partner
J. Biol. Chem. 2008 283: 15089-15096. First Published on April 2, 2008; doi:10.1074/jbc.M710452200 [Abstract] [Full Text] [PDF]

Wladimir Malaga, Patricia Constant, Daniel Euphrasie, Angel Cataldi, Mamadou Daffé, Jean-Marc Reyrat, and Christophe Guilhot: Deciphering the Genetic Bases of the Structural Diversity of Phenolic Glycolipids in Strains of the Mycobacterium tuberculosis Complex
J. Biol. Chem. 2008 283: 15177-15184. First Published on April 4, 2008; doi:10.1074/jbc.M710275200 [Abstract] [Full Text] [PDF]

Membrane Transport, Structure, Function, and Biogenesis:

Maria A. Spassova, Thamara Hewavitharana, Richard A. Fandino, Asli Kaya, Jacqueline Tanaka, and Donald L. Gill: Voltage Gating at the Selectivity Filter of the Ca²⁺ Release-activated Ca²⁺ Channel Induced by Mutation of the Orai1 Protein
J. Biol. Chem. 2008 283: 14938-14945. First Published on December 20, 2007; doi:10.1074/jbc.M702208200 [Abstract] [Full Text] [PDF]

Tomohiro Numata and Yasunobu Okada: Proton Conductivity through the Human TRPM7 Channel and Its Molecular Determinants
J. Biol. Chem. 2008 283: 15097-15103. First Published on April 4, 2008; doi:10.1074/jbc.M709261200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Samuel J. Fountain, Lishuang Cao, Mark T. Young, and R. Alan North: Permeation Properties of a P2X Receptor in the Green Algae Ostreococcus tauri
J. Biol. Chem. 2008 283: 15122-15126. First Published on April 1, 2008; doi:10.1074/jbc.M801512200 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE

Riki Kawaguchi, Jiamei Yu, Patrick Wiita, Jane Honda, and Hui Sun: An Essential Ligand-binding Domain in the Membrane Receptor for Retinol-binding Protein Revealed by Large-scale Mutagenesis and a Human Polymorphism
J. Biol. Chem. 2008 283: 15160-15168. First Published on April 3, 2008; doi:10.1074/jbc.M801060200 [Abstract] [Full Text] [PDF]

Baoxue Yang, Zsolt Zador, and A. S. Verkman: Glial Cell Aquaporin-4 Overexpression in Transgenic Mice Accelerates Cytotoxic Brain Swelling
J. Biol. Chem. 2008 283: 15280-15286. First Published on March 28, 2008; doi:10.1074/jbc.M801425200 [Abstract] [Full Text] [PDF]

Molecular Basis Of Cell and Developmental Biology:

Vi Luan Ha, Sanita Bharti, Hiroki Inoue, William C. Vass, Fanny Campa, Zhongzhen Nie, Armand de Gramont, Yvona Ward, and Paul A. Randazzo: ASAP3 Is a Focal Adhesion-associated Arf GAP That Functions in Cell Migration and Invasion
J. Biol. Chem. 2008 283: 14915-14926. First Published on April 8, 2008; doi:10.1074/jbc.M709717200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Hyojin Lee, Jeong Soo Cho, Nils Lambacher, Jieun Lee, Se-Jin Lee, Tae Hoon Lee, Anton Gartner, and Hyeon-Sook Koo: The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for Resistance to Oxidative Stress and for Normal Motility and Foraging Behavior
J. Biol. Chem. 2008 283: 14988-14993. First Published on April 11, 2008; doi:10.1074/jbc.M709115200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Dana M. Gheorghe, Soheil Aghamohammadzadeh, Iwona I. Smaczynska-de Rooij, Ellen G. Allwood, Steve J. Winder, and Kathryn R. Ayscough: Interactions between the Yeast SM22 Homologue Scp1 and Actin Demonstrate the Importance of Actin Bundling in Endocytosis
J. Biol. Chem. 2008 283: 15037-15046. First Published on April 8, 2008; doi:10.1074/jbc.M710332200 [Abstract] [Full Text] [PDF] [ Supplemental Data] AUTHOR'S CHOICE

Yong Li, Cynthia Suggs, J. Timothy Wright, Zhi-an Yuan, Melissa Aragon, Hanson Fong, Darrin Simmons, Bill Daly, Ellis E. Golub, Gerald Harrison, Ashok B. Kulkarni, and Carolyn W. Gibson: Partial Rescue of the Amelogenin Null Dental Enamel Phenotype
J. Biol. Chem. 2008 283: 15056-15062. First Published on April 3, 2008; doi:10.1074/jbc.M707992200 [Abstract] [Full Text] [PDF]

Kyoko Takahashi, Natsuko Hayashi, Toshibumi Shimokawa, Nagayoshi Umehara, Shuichi Kaminogawa, and Chisei Ra: Cooperative Regulation of Fc Receptor ${gamma}$ -Chain Gene Expression by Multiple Transcription Factors, Including Sp1, GABP, and Elf-1
J. Biol. Chem. 2008 283: 15134-15141. First Published on March 31, 2008; doi:10.1074/jbc.M800498200 [Abstract] [Full Text] [PDF]

Daisuke Imamura, Ruanbao Zhou, Michael Feig, and Lee Kroos: Evidence That the Bacillus subtilis SpoIIGA Protein Is a Novel Type of Signal-transducing Aspartic Protease
J. Biol. Chem. 2008 283: 15287-15299. First Published on March 31, 2008; doi:10.1074/jbc.M708962200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Chang Hyun Byon, Amjad Javed, Qun Dai, John C. Kappes, Thomas L. Clemens, Victor M. Darley-Usmar, Jay M. McDonald, and Yabing Chen: Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling
J. Biol. Chem. 2008 283: 15319-15327. First Published on March 31, 2008; doi:10.1074/jbc.M800021200 [Abstract] [Full Text] [PDF]

Mechanisms Of Signal Transduction:

Nicola J. Bright, David Carling, and Claire Thornton: Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation
J. Biol. Chem. 2008 283: 14946-14954. First Published on March 13, 2008; doi:10.1074/jbc.M710381200 [Abstract] [Full Text] [PDF]

Hiromi Takaki, Kenji Ichiyama, Keiko Koga, Takatoshi Chinen, Giichi Takaesu, Yuki Sugiyama, Shigeaki Kato, Akihiko Yoshimura, and Takashi Kobayashi
: STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor
J. Biol. Chem. 2008 283: 14955-14962. First Published on April 9, 2008; doi:10.1074/jbc.M801123200 [Abstract] [Full Text] [PDF] [Supplemental Data] Faculty of 1000 *Recommended* - FREE!

Baskaran Thyagarajan, Viktor Lukacs, and Tibor Rohacs: Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels
J. Biol. Chem. 2008 283: 14980-14987. First Published on April 7, 2008; doi:10.1074/jbc.M704224200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Heun Soh and Steve A. N. Goldstein: I_SA Channel Complexes Include Four Subunits Each of DPP6 and Kv4.2
J. Biol. Chem. 2008 283: 15072-15077. First Published on March 25, 2008; doi:10.1074/jbc.M706964200 [Abstract] [Full Text] [PDF]

Nicolas Audet, Céline Galés, Élodie Archer-Lahlou, Marc Vallières, Peter W. Schiller, Michel Bouvier, and Graciela Pineyro: Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing ${delta}$ -Opioid Receptors and Heterotrimeric G Proteins
J. Biol. Chem. 2008 283: 15078-15088. First Published on April 1, 2008; doi:10.1074/jbc.M707941200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Kittipong Tachampa, Tomoyoshi Kobayashi, Helen Wang, Anne F. Martin, Brandon J. Biesiadecki, R. John Solaro, and Pieter P. de Tombe: Increased Cross-bridge Cycling Kinetics after Exchange of C-terminal Truncated Troponin I in Skinned Rat Cardiac Muscle
J. Biol. Chem. 2008 283: 15114-15121. First Published on March 31, 2008; doi:10.1074/jbc.M801636200 [Abstract] [Full Text] [PDF]

Sohini Mukherjee, Veera S. Negi, Gladys Keitany, Yuetsu Tanaka, and Kim Orth: In Vitro Activation of the I ${kappa}$ B Kinase Complex by Human T-cell Leukemia Virus Type-1 Tax
J. Biol. Chem. 2008 283: 15127-15133. First Published on January 26, 2008; doi:10.1074/jbc.M704831200 [Abstract] [Full Text] [PDF]

Thore Hillig, Lars H. Engelholm, Signe Ingvarsen, Daniel H. Madsen, Henrik Gårdsvoll, Jørgen K. Larsen, Michael Ploug, Keld Danø, Lars Kjøller, and Niels Behrendt: A Composite Role of Vitronectin and Urokinase in the Modulation of Cell Morphology upon Expression of the Urokinase Receptor
J. Biol. Chem. 2008 283: 15217-15223. First Published on March 24, 2008; doi:10.1074/jbc.C700214200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Jose Mercado and Cynthia Czajkowski: ${gamma}$ -Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the GABA_A Receptor ${alpha}$ ₁ and β₂ Pre-M1 Regions
J. Biol. Chem. 2008 283: 15250-15257. First Published on April 3, 2008; doi:10.1074/jbc.M708638200 [Abstract] [Full Text] [PDF]

Young-In Kim, Jeoung-Eun Park, Antonio Martinez-Hernandez, and Ae-Kyung Yi: CpG DNA Prevents Liver Injury and Shock-mediated Death by Modulating Expression of Interleukin-1 Receptor-associated Kinases
J. Biol. Chem. 2008 283: 15258-15270. First Published on March 31, 2008; doi:10.1074/jbc.M709549200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Francesco Massimo Lasorsa, Paolo Pinton, Luigi Palmieri, Pasquale Scarcia, Hanspeter Rottensteiner, Rosario Rizzuto, and Ferdinando Palmieri: Peroxisomes as Novel Players in Cell Calcium Homeostasis
J. Biol. Chem. 2008 283: 15300-15308. First Published on March 25, 2008; doi:10.1074/jbc.M800648200 [Abstract] [Full Text] [PDF]

Seda Eminaga and Anton M. Bennett: Noonan Syndrome-associated SHP-2/Ptpn11 Mutants Enhance SIRP ${alpha}$ and PZR Tyrosyl Phosphorylation and Promote Adhesion-mediated ERK Activation
J. Biol. Chem. 2008 283: 15328-15338. First Published on March 31, 2008; doi:10.1074/jbc.M801382200 [Abstract] [Full Text] [PDF]

Chunlai Nie, Changhai Tian, Lixia Zhao, Patrice Xavier Petit, Maryam Mehrpour, and Quan Chen: Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H₂O₂-induced Apoptosis
J. Biol. Chem. 2008 283: 15359-15369. First Published on March 15, 2008; doi:10.1074/jbc.M800847200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Kenjiro Sakaki, Jun Wu, and Randal J. Kaufman: Protein Kinase C ${theta}$ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum
J. Biol. Chem. 2008 283: 15370-15380. First Published on March 20, 2008; doi:10.1074/jbc.M710209200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Thiagarajan Srimathi, Sheila L. Robbins, Rachel L. Dubas, Helen Chang, Hong Cheng, Heinrich Roder, and Young Chul Park: Mapping of POP1-binding Site on Pyrin Domain of ASC
J. Biol. Chem. 2008 283: 15390-15398. First Published on March 24, 2008; doi:10.1074/jbc.M801589200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Punita Dhawan, Yingjun Su, Yee Mon Thu, Yingchun Yu, Paige Baugher, Darrel L. Ellis, Tammy Sobolik-Delmaire, Mark Kelley, Timothy C. Cheung, Carl F. Ware, and Ann Richmond: The Lymphotoxin-β Receptor Is an Upstream Activator of NF- ${kappa}$ B-mediated Transcription in Melanoma Cells
J. Biol. Chem. 2008 283: 15399-15408. First Published on March 17, 2008; doi:10.1074/jbc.M708272200 [Abstract] [Full Text] [PDF]

Susan E. Levin, Chao Zhang, Theresa A. Kadlecek, Kevan M. Shokat, and Arthur Weiss: Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
J. Biol. Chem. 2008 283: 15419-15430. First Published on March 31, 2008; doi:10.1074/jbc.M709000200 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE

Venugopalan D. Nair and C. Warren Olanow: Differential Modulation of Akt/Glycogen Synthase Kinase-3β Pathway Regulates Apoptotic and Cytoprotective Signaling Responses
J. Biol. Chem. 2008 283: 15469-15478. First Published on April 3, 2008; doi:10.1074/jbc.M707238200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Wanqing Li, Susan L. Young, Nicole King, and W. Todd Miller: Signaling Properties of a Non-metazoan Src Kinase and the Evolutionary History of Src Negative Regulation
J. Biol. Chem. 2008 283: 15491-15501. First Published on April 4, 2008; doi:10.1074/jbc.M800002200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Biomolecular Networks:

Tom Janssen, Steven J. Husson, Marleen Lindemans, Inge Mertens, Suzanne Rademakers, Kris Ver Donck, Johan Geysen, Gert Jansen, and Liliane Schoofs: Functional Characterization of Three G Protein-coupled Receptors for Pigment Dispersing Factors in Caenorhabditis elegans
J. Biol. Chem. 2008 283: 15241-15249. First Published on April 4, 2008; doi:10.1074/jbc.M709060200 [Abstract] [Full Text] [PDF] [Supplemental Data]

Roger S. Chung, Milena Penkowa, Justin Dittmann, Carolyn E. King, Carole Bartlett, Johanne W. Asmussen, Juan Hidalgo, Javier Carrasco, Yee Kee J. Leung, Adam K. Walker, Samantha J. Fung, Sarah A. Dunlop, Melinda Fitzgerald, Lyn D. Beazley, Meng I. Chuah, James C. Vickers, and Adrian K. West: Redefining the Role of Metallothionein within the Injured Brain: EXTRACELLULAR METALLOTHIONEINS PLAY AN IMPORTANT ROLE IN THE ASTROCYTE-NEURON RESPONSE TO INJURY
J. Biol. Chem. 2008 283: 15349-15358. First Published on March 11, 2008; doi:10.1074/jbc.M708446200 [Abstract] [Full Text] [PDF]

Additions and Corrections:

Tanya R. Porras-Yakushi, Julian P. Whitelegge, and Steven Clarke: A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at the N terminus. VOLUME 281 (2006) PAGES 35835-35845
J. Biol. Chem. 2008 283: 15512. [Full Text] [PDF]

Navjotsingh Pabla, Shuang Huang, Qing-Sheng Mi, Rene Daniel, and Zheng Dong: ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. VOLUME 283 (2008) PAGES 6572-6583
J. Biol. Chem. 2008 283: 15512-a. [Full Text] [PDF]