Searching journal content for Alzheimer disease (as phrase) in full text.

Displaying results 1-10 of 2510
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  1. Protein Structure and Folding - Molecular Bases of Disease:
    • Patrick Constantinescu,
    • Rebecca A Brown,
    • Amy R Wyatt,
    • Marie Ranson,
    • and Mark R Wilson
    Amorphous protein aggregates stimulate plasminogen activation, leading to release of cytotoxic fragments that are clients for extracellular chaperones J. Biol. Chem. jbc.M117.786657. doi:10.1074/jbc.M117.786657
    ...and facilitate their safe clearance and disposal. This is relevant to a broad variety of serious human diseases, the protein deposition diseases (PDDs), in which pathology is associated with inappropriate misfolding, aggregation and deposition of extracellular proteins (e.g. Alzheimer's disease, type II diabetes ~~~
  2. Enzymology:
    • Aaron P. Landry,
    • David P. Ballou,
    • and Ruma Banerjee
    H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase J. Biol. Chem. 2017 292: 11641-. doi:10.1074/jbc.M117.788547
    ...Alzheimer disease ~~~
  3. Metabolism - Molecular Bases of Disease:
    • Yusuke Nakatsu,
    • Keiichi Mori,
    • Yasuka Matsunaga,
    • Takeshi Yamamotoya,
    • Koji Ueda,
    • Yuki Inoue,
    • Keiko Mitsuzaki-Miyoshi,
    • Hideyuki Sakoda,
    • Midori Fujishiro,
    • Suguru Yamaguchi,
    • Akifumi Kushiyama,
    • Hiraku Ono,
    • Hisamitsu Ishihara,
    • and Tomoichiro Asano
    The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion J. Biol. Chem. 2017 292: 11886-. doi:10.1074/jbc.M117.780726
    ...Alzheimer disease ~~~
  4. Enzymology - Protein Structure and Folding:
    • David L. Nelson,
    • Gregory A. Applegate,
    • Matthew L. Beio,
    • Danielle L. Graham,
    • and David B. Berkowitz
    Human Serine Racemase Structure/Activity Relationship Studies Provide Mechanistic Insight and Point to Position-84 as a Hotspot for β-Elimination Function J. Biol. Chem. jbc.M117.777904. doi:10.1074/jbc.M117.777904
    ...SR), the enzyme responsible for producing the NMDA coagonist D-serine. Reported correlation of Dserine levels with disorders including Alzheimers disease, ALS and ischemic brain damage (elevated D-serine), and schizophrenia (reduced D-serine) has further piqued this interest. Reported is a structure ~~~
  5. Signal Transduction - Metabolism:
    • Bronwen Martin,
    • Rui Wang,
    • Wei-Na Cong,
    • Caitlin M. Daimon,
    • Wells W. Wu,
    • Bin Ni,
    • Kevin G. Becker,
    • Elin Lehrmann,
    • William H. Wood III,
    • Yongqing Zhang,
    • Harmonie Etienne,
    • Jaana van Gastel,
    • Abdelkrim Azmi,
    • Jonathan Janssens,
    • and Stuart Maudsley
    Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction J. Biol. Chem. 2017 292: 11508-. doi:10.1074/jbc.M116.773820
    ...Alzheimer disease . Expert Rev. Mol. Med . 13 , e21 86. ↵ Choi , K. J. , Kim , M. J. , Je , A. R. , Jun , S. , Lee , C. , Lee , E. , Jo , M. , Huh , Y. H. , and Kweon , H. S. ( 2014 ) Three-dimensional analysis of abnormal ultrastructural alteration in mitochondria of hippocampus of APP/PSEN1 transg ~~~
  6. Molecular Bases of Disease - Cell Biology:
    • Michael R. Butler,
    • Hongwei Ma,
    • Fan Yang,
    • Joshua Belcher,
    • Yun-Zheng Le,
    • Katsuhiko Mikoshiba,
    • Martin Biel,
    • Stylianos Michalakis,
    • Anthony Iuso,
    • David Križaj,
    • and Xi-Qin Ding
    Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency J. Biol. Chem. 2017 292: 11189-. doi:10.1074/jbc.M117.782326
    ...Alzheimer disease ~~~
  7. Molecular Bases of Disease - Protein Structure and Folding:
    • Tyler J. Perlenfein,
    • Jacob D. Mehlhoff,
    • and Regina M. Murphy
    Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid J. Biol. Chem. 2017 292: 11485-. doi:10.1074/jbc.M117.786558
    ...Alzheimer disease patients. J. Neuropathol. Exp. Neurol. 60, 94–104 28. Coria, F., Castan˜o, E.M., and Frangione, B. (1987) Brain amyloid in normal aging and cerebral amyloid angiopathy is antigenically related to Alzheimer’s disease beta-protein. Am. J. Pathol. 129, 422–428 29. Mi, W., Jung, S. S., ~~~
  8. Neurobiology - Molecular Bases of Disease:
    • Takashi Mori,
    • Naoki Koyama,
    • Jun Tan,
    • Tatsuya Segawa,
    • Masahiro Maeda,
    • and Terrence Town
    Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease J. Biol. Chem. 2017 292: 11310-. doi:10.1074/jbc.M116.762658
    ...Alzheimer disease in rats: electrophysiological and histological studies. Basic Clin. Neurosci. 7, 97–106 47. Kim, M. J., Seong, A. R., Yoo, J. Y., Jin, C. H., Lee, Y. H., Kim, Y. J., Lee, J., Jun, W. J., and Yoon, H. G. (2011) Gallic acid, a histone acetyltransferase inhibitor, suppresses -amyloid ~~~
  9. Methods and Resources - Neurobiology:
    • Lies Schoonaert,
    • Laura Rué,
    • Bart Roucourt,
    • Mieke Timmers,
    • Susan Little,
    • Lucía Chávez-Gutiérrez,
    • Maarten Dewilde,
    • Peter Joyce,
    • Adam Curnock,
    • Peter Weber,
    • Jurgen Haustraete,
    • Gholamreza Hassanzadeh-Ghassabeh,
    • Bart De Strooper,
    • Ludo Van Den Bosch,
    • Philip Van Damme,
    • Robin Lemmens,
    • and Wim Robberecht
    Identification and characterization of Nanobodies targeting the EphA4 receptor J. Biol. Chem. 2017 292: 11452-. doi:10.1074/jbc.M116.774141
    ...Alzheimer disease ~~~
    AUTHOR'S CHOICE
  10. Protein Synthesis and Degradation - Gene Regulation:
    • Oscar Perez-Leal,
    • Carlos Alberto Barrero,
    • and Salim Merali
    Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses J. Biol. Chem. jbc.M116.770925. doi:10.1074/jbc.M116.770925
    ..., 931-947 3. Kirkham, P. A., and Barnes, P. J. (2013) Oxidative stress in COPD. Chest 144, 266-273 4. Butterfield, D. A., Swomley, A. M., and Sultana, R. (2013) Amyloid beta-peptide (1-42)induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxidants ~~~
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