Searching journal content for Ctr1 (as phrase) in full text.

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  1. Cell Biology - Metabolism:
    • Brandon L. Logeman,
    • L. Kent Wood,
    • Jaekwon Lee,
    • and Dennis J. Thiele
    Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 J. Biol. Chem. 2017 292: 11531-. doi:10.1074/jbc.M117.793356
    ...the plasmamembrane and endomembranes. Althoughmammalian Ctr1 functions as a Cu transporter for Cu acquisition and is essential for embryonic development, a homologous protein, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of Ctr1 activity, but its ~~~
  2. Cell Biology - Metabolism:
    • Filip Liebsch,
    • Mark R. P. Aurousseau,
    • Tobias Bethge,
    • Hugo McGuire,
    • Silvia Scolari,
    • Andreas Herrmann,
    • Rikard Blunck,
    • Derek Bowie,
    • and Gerd Multhaup
    Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization J. Biol. Chem. jbc.M117.779165. doi:10.1074/jbc.M117.779165
    ...M470 motif with a Cu(I) binding site that resembles the low-affinity copper binding sites of the copper transport protein Ctr1 (1114). Despite the past success in identifying the key physiological binding partners and substrates of BACE1 (15), relatively little is known about the assembly ~~~
  3. Molecular Biophysics - Protein Structure and Folding:
    • Morgan M. Fetherolf,
    • Stefanie D. Boyd,
    • Alexander B. Taylor,
    • Hee Jong Kim,
    • James A. Wohlschlegel,
    • Ninian J. Blackburn,
    • P. John Hart,
    • Dennis R. Winge,
    • and Duane D. Winkler
    Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site J. Biol. Chem. jbc.M117.775981. doi:10.1074/jbc.M117.775981
    ...the membrane transporter Ctr1 (9, 14, 15). The second domain (D2) possesses significant sequence and structural similarity with Sod1 that permits it to mediate interaction with the immature molecule via residues analogous to those found at the Sod1 homodimeric interface (8, 16-19). Like D2, the Cterminal ~~~
  4. Gene Regulation - DNA and Chromosomes:
    • Yijun Qiu and
    • David S. Gilmour
    Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing J. Biol. Chem. 2017 292: 5555-. doi:10.1074/jbc.M116.760751
    ...-, threonine-, and proline-rich repeating region called the CTR, which is further divided into CTR1 and CTR2 based on repeating amino acid sequences (11, 32). CTR1 can be phosphorylated by P-TEFb at Thr-4 of the consensus repeat GS(R/Q)TP, and this phosphorylation is critical for DSIF-mediated stimulation ~~~
  5. Molecular Bases of Disease - Metabolism:
    • Ashima Bhattacharjee,
    • Haojun Yang,
    • Megan Duffy,
    • Emily Robinson,
    • Arianrhod Conrad-Antoville,
    • Ya-Wen Lu,
    • Tony Capps,
    • Lelita Braiterman,
    • Michael Wolfgang,
    • Michael P. Murphy,
    • Ling Yi,
    • Stephen G. Kaler,
    • Svetlana Lutsenko,
    • and Martina Ralle
    The Activity of Menkes Disease Protein ATP7A Is Essential for Redox Balance in Mitochondria J. Biol. Chem. 2016 291: 16644-. doi:10.1074/jbc.M116.727248
    ...are involved in physiological processes that are indispensable for life. Consequently, copper deficiency is deleterious and can result in death (1, 2). Copper is transported into cells predominantly by a copper transporter, CTR1. This process is facilitated by intracellular glutathione (3). Excess copper ~~~
    AUTHOR'S CHOICE
  6. Cell Biology - Metabolism:
    • Helena Öhrvik,
    • Brandon Logeman,
    • Boris Turk,
    • Thomas Reinheckel,
    • and Dennis J. Thiele
    Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain J. Biol. Chem. 2016 291: 13905-. doi:10.1074/jbc.M116.731281
    ...acquisition, cardiac function, neuropeptide biogenesis, and other critical physiological processes. Ctr1 is a high affinity Cu+ transporter on the plasma membrane and endosomes that exists as a full-length protein and a truncated form of Ctr1 lacking the methionine- and histidine-rich metal-binding ectodomain ~~~
  7. Cell Biology - Metabolism:
    • Xiaobin Wu,
    • Heejeong Kim,
    • Javier Seravalli,
    • Joseph J. Barycki,
    • P. John Hart,
    • David W. Gohara,
    • Enrico Di Cera,
    • Won Hee Jung,
    • Daniel J. Kosman,
    • and Jaekwon Lee
    Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase J. Biol. Chem. 2016 291: 9796-. doi:10.1074/jbc.M115.700500
    ...RI and PstI sites of the pCM64-lacZ vector (28). pCM64-FET3-lacZ and pCM64-CTR1-lacZ reporter plasmids (29, 30) determined FET3 and CTR1 gene expression, respectively. A reporter plasmid containing unfolded protein response elements (UPRE) was described previously (31). p316GALlcc1 plasmid contains a gene ~~~
  8. Cell Biology - Protein Synthesis and Degradation:
    • Marta Isasa,
    • Clara Suñer,
    • Miguel Díaz,
    • Pilar Puig-Sàrries,
    • Alice Zuin,
    • Anne Bichman,
    • Steven P. Gygi,
    • Elena Rebollo,
    • and Bernat Crosas
    Cold Temperature Induces the Reprogramming of Proteolytic Pathways in Yeast J. Biol. Chem. 2016 291: 1664-. doi:10.1074/jbc.M115.698662
    ...), and the high affinity copper transporter Ctr1 (Fig. 1C and supplemental Table 1) (7, 33, 34). The lysines modified by ubiquitin in PM proteins were exclusively located in the cytosolic loops of the proteins, and no structurally incoherent sites (located in intramembrane or extracellular loops) were identified ~~~
  9. Lipids - Membrane Biology:
    • Rania M. Deranieh,
    • Yihui Shi,
    • Maureen Tarsio,
    • Yan Chen,
    • J. Michael McCaffery,
    • Patricia M. Kane,
    • and Miriam L. Greenberg
    Perturbation of the Vacuolar ATPase: A NOVEL CONSEQUENCE OF INOSITOL DEPLETION J. Biol. Chem. 2015 290: 27460-. doi:10.1074/jbc.M115.683706
    ...MRPL27 MMT2 AIM13 MCS19 5 Transporters TRK1 CTR1 GUP1 HXT12 AQR1 TFP3 ATP15 RTC2 SPF1 COD1 6 Functionally unrelated other IRA1 NPL3 RMD7 SER2 PAC10 KAR3 NCL1 NPL6 BUB1 SPC72 MOG1 FYV6 SDL1 TRP1 NIS1 MKT1 CTK1 TRX3 RPL21A ERF2 CAT2 GSH1 SLI15 NHP10 KEM1 SCS2 POC4 ~~~
  10. Cell Biology - Signal Transduction:
    • Norihiko Sasaki,
    • Yoko Itakura,
    • and Masashi Toyoda
    Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells J. Biol. Chem. 2015 290: 25475-. doi:10.1074/jbc.M115.684274
    ...Late pass Early pass Late pass Early pass IR 1 5 0 5 1 5 0 5 1 5 0 5 cell surface IR 150 100 60 kDa 60 kDa 140 kDa 140 kDa Akt pAkt eNOS peNOS H2O2 H2O2Ctr Ctr insulin ita pAkt Akt H2O2 H2O2Ctr Ctr insulin 1 5 0 5 2 1 5 0 5 peNOS eNOS H2O2 H2O2Ctr Ctr insulin H2O2Ctr 1 5 0 5 IRS1 H2O2Ctr ~~~
    AUTHOR'S CHOICE
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