Searching journal content for Ctr2 (as phrase) in full text.

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  1. Microbiology - Developmental Biology:
    • Samuel Plante,
    • Vincent Normant,
    • Karla M. Ramos-Torres,
    • and Simon Labbé
    Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination J. Biol. Chem. 2017 292: 11896-. doi:10.1074/jbc.M117.794677
    ...to at least one cytosolic copper-dependent enzyme under low-copper conditions (22, 23).On the basis of studies on Ctr6 and its ortholog Ctr2 in Saccharomyces cerevisiae (24, 25), Ctr6 has been predicted to function as a vacuolar membrane copper transporter that mobilizes stored copper from the vacuole ~~~
  2. Cell Biology - Metabolism:
    • Brandon L. Logeman,
    • L. Kent Wood,
    • Jaekwon Lee,
    • and Dennis J. Thiele
    Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 J. Biol. Chem. 2017 292: 11531-. doi:10.1074/jbc.M117.793356
    ...the plasmamembrane and endomembranes. Althoughmammalian Ctr1 functions as a Cu transporter for Cu acquisition and is essential for embryonic development, a homologous protein, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or a regulator of Ctr1 activity, but its ~~~
  3. Gene Regulation - DNA and Chromosomes:
    • Yijun Qiu and
    • David S. Gilmour
    Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing J. Biol. Chem. 2017 292: 5555-. doi:10.1074/jbc.M116.760751
    ...-, threonine-, and proline-rich repeating region called the CTR, which is further divided into CTR1 and CTR2 based on repeating amino acid sequences (11, 32). CTR1 can be phosphorylated by P-TEFb at Thr-4 of the consensus repeat GS(R/Q)TP, and this phosphorylation is critical for DSIF-mediated stimulation ~~~
  4. Cell Biology - Metabolism:
    • Helena Öhrvik,
    • Brandon Logeman,
    • Boris Turk,
    • Thomas Reinheckel,
    • and Dennis J. Thiele
    Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain J. Biol. Chem. 2016 291: 13905-. doi:10.1074/jbc.M116.731281
    ...membrane protein similar to Ctr1, denoted Ctr2, was shown to both interact with and regulate the ratio of full-length Ctr1 to tCtr1 in mouse embryonic fibroblasts (MEFs) and in specific tissues in Ctr2 knock-out mice (32). In the absence of Ctr2, MEFs possess dramatically lower levels of tCtr1, while ~~~
  5. Minireviews - Microbiology:
    • Sarela García-Santamarina and
    • Dennis J. Thiele
    Copper at the Fungal Pathogen-Host Axis J. Biol. Chem. 2015 290: 18945-. doi:10.1074/jbc.R115.649129
    ...Alternatively Cu could be provided through the fusion of Cuenriched endosomal compartments found in cells in which the Ctr1 high affinity Cu transporter localized to both the plasma membrane and the endosomes fails to be efficiently cleaved through stimulation by the Ctr2 protein 59 Perhaps in some ~~~
  6. Minireviews - Microbiology - Molecular Bases of Disease:
    • Karrera Y. Djoko,
    • Cheryl-lynn Y. Ong,
    • Mark J. Walker,
    • and Alastair G. McEwan
    The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens J. Biol. Chem. 2015 290: 18954-. doi:10.1074/jbc.R115.647099
    ...it usually resides in the Golgi apparatus This expression of ATP7A was accompanied by robust increases in the expression of CTR1 and CTR2 which encode for transporters for the import of Cu I into the cytoplasm and CP which encodes for ceruloplasmin 15 These alterations in the expression of genes ~~~
  7. Cell Biology - Glycobiology and Extracellular Matrices:
    • Jun Li,
    • Wen Yuan,
    • Shuai Jiang,
    • Wei Ye,
    • Hao Yang,
    • Irving M. Shapiro,
    • and Makarand V. Risbud
    Prolyl-4-hydroxylase Domain Protein 2 Controls NF-κB/p65 Transactivation and Enhances the Catabolic Effects of Inflammatory Cytokines on Cells of the Nucleus Pulposus J. Biol. Chem. 2015 290: 7195-. doi:10.1074/jbc.M114.611483
    ...SDC4 1 2 3 shPHD2 GFPA PHD3 1 2 3 C D 1 ShCTR 2 ShCTR TNF 3 ShPHD2 TNF tiv sh 16 E MMP13 sio 1 2 3 ADT5F 1 2 3 0 0 0 5 1 0 1 5 2 0 AggrecanG 1 2 3 0 0 0 5 1 0 1 5 2 0 CollagenH 1 2 3 1 2 3 1 2 3 1 2 3 tiv sh TR PHD2 PHD3 SDC4 COX2 MMP3 1 2 3 1 2 3 COX2 PHD2 GAPDH SDC4 shCTR shCTR sh ~~~
  8. Minireviews - Metabolism - Plant Biology:
    • Crysten E. Blaby-Haas and
    • Sabeeha S. Merchant
    Lysosome-related Organelles as Mediators of Metal Homeostasis J. Biol. Chem. 2014 289: 28129-. doi:10.1074/jbc.R114.592618
    ...compartment 64 suggesting that the acidic pH of the lumen likely alters the affinity of the ectodomain for Cu1 65 hence inhibiting transport In S cerevisiae Ctr2p 66 68 and the reductase Fre6p are responsible forCu1 transport from the vacuole In the absence of the assimilatory transporters Ctr1p ~~~
  9. Developmental Biology - Microbiology:
    • Samuel Plante,
    • Raphaël Ioannoni,
    • Jude Beaudoin,
    • and Simon Labbé
    Characterization of Schizosaccharomyces pombe Copper Transporter Proteins in Meiotic and Sporulating Cells J. Biol. Chem. 2014 289: 10168-. doi:10.1074/jbc.M113.543678
    ...On the basis of studies on Ctr6 and its ortholog Ctr2 in S cerevisiae 14 15 a current model suggests that Ctr6 mediates the efflux of copper from the vacuole into the cytosol when cells undergo a transition from copper sufficient to copper limiting conditions Meiosis is a specialized mode of cell ~~~
  10. Signal Transduction - Immunology:
    • Niko P. Bretz,
    • Johannes Ridinger,
    • Anne-Kathleen Rupp,
    • Katharina Rimbach,
    • Sascha Keller,
    • Christian Rupp,
    • Frederik Marmé,
    • Ludmila Umansky,
    • Viktor Umansky,
    • Tatjana Eigenbrod,
    • Marei Sammar,
    • and Peter Altevogt
    Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling J. Biol. Chem. 2013 288: 36691-. doi:10.1074/jbc.M113.512806
    ...in Fig 1G emphasized that an LPS contamination was unlikely to be the source of triggering Our data rather suggested that a protein determinant associated with exosomes is responsible for the induction of p65 phosphorylation ctr 2h 6h 12 2h 6h 12 AF Exos AS Exos p STAT3 STAT3 p p65 p65 GAPDH Exos only ~~~
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