Searching journal content for NAD biosynthesis (as phrase) in full text.

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  1. Accelerated Communications - Metabolism - Bioenergetics:
    • Melanie R. McReynolds,
    • Wenqing Wang,
    • Lauren M. Holleran,
    • and Wendy Hanna-Rose
    Uridine monophosphate synthetase enables eukaryotic de novo NAD+ biosynthesis from quinolinic acid J. Biol. Chem. 2017 292: 11147-. doi:10.1074/jbc.C117.795344
    ...Uridine monophosphate synthetase enables eukaryotic de novo NAD biosynthesis from quinolinic acid Received for publication,May 8, 2017, and in revised form, May 25, 2017 Published, Papers in Press, May 30, 2017, DOI 10.1074/.C117.795344 Melanie R. McReynolds, WenqingWang1, Lauren M. Holleran, and X ~~~
  2. Metabolism - Cell Biology:
    • Magali R. VanLinden,
    • Christian Dölle,
    • Ina K. N. Pettersen,
    • Veronika A. Kulikova,
    • Marc Niere,
    • Gennaro Agrimi,
    • Sissel E. Dyrstad,
    • Ferdinando Palmieri,
    • Andrey A. Nikiforov,
    • Karl Johan Tronstad,
    • and Mathias Ziegler
    Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells J. Biol. Chem. 2015 290: 27644-. doi:10.1074/jbc.M115.654129
    ...not been identified In contrast human recombinant NMNAT3 localizes to the mitochondrial matrix and is able to catalyze NAD biosynthesis in vitro However whether the endogenous NMNAT3 protein is functionally effective at generating NAD in mitochondria of intact human cells still remains ~~~
  3. Metabolism - Enzymology:
    • Veronika Kulikova,
    • Konstantin Shabalin,
    • Kirill Nerinovski,
    • Christian Dölle,
    • Marc Niere,
    • Alexander Yakimov,
    • Philip Redpath,
    • Mikhail Khodorkovskiy,
    • Marie E. Migaud,
    • Mathias Ziegler,
    • and Andrey Nikiforov
    Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells J. Biol. Chem. 2015 290: 27124-. doi:10.1074/jbc.M115.664458
    ..., NAD must be permanently resynthesized. Nicotinamide and nicotinic acid as well as nicotinamide riboside (NR) and nicotinic acid riboside (NAR) are the major precursors for NAD biosynthesis in humans. In this study, we exploredwhether the ribosidesNRandNARcanbe generated in human cells. We demonstrate ~~~
  4. Developmental Biology - Metabolism:
    • Wenqing Wang,
    • Melanie R. McReynolds,
    • Jimmy F. Goncalves,
    • Muya Shu,
    • Ineke Dhondt,
    • Bart P. Braeckman,
    • Stephanie E. Lange,
    • Kelvin Kho,
    • Ariana C. Detwiler,
    • Marisa J. Pacella,
    • and Wendy Hanna-Rose
    Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans J. Biol. Chem. 2015 290: 26163-. doi:10.1074/jbc.M115.662916
    ...Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis Stemming from Lack of Salvage NAD Biosynthesis Impairs Reproductive Development in Caenorhabditis elegans S Received for publication May 4 2015 and in revised form August 22 2015 Published JBC Papers in Press September 8 ~~~
  5. Protein Structure and Folding:
    • Shiheng Liu,
    • Tiantian Su,
    • Cong Zhang,
    • Wen-Mao Zhang,
    • Deyu Zhu,
    • Jing Su,
    • Tiandi Wei,
    • Kang Wang,
    • Yan Huang,
    • Liming Guo,
    • Sujuan Xu,
    • Ning-Yi Zhou,
    • and Lichuan Gu
    Crystal Structure of PnpCD, a Two-subunit Hydroquinone 1,2-Dioxygenase, Reveals a Novel Structural Class of Fe2+-dependent Dioxygenases J. Biol. Chem. 2015 290: 24547-. doi:10.1074/jbc.M115.673558
    ...NAD biosynthesis Biochemistry 44 7632 7643 34 Colabroy K L Zhai H Li T Ge Y Zhang Y Liu A Ealick S E McLafferty F W and Begley T P 2005 Themechanism of inactivation of 3 hydroxyanthranilate 3 4 dioxygenase by 4 chloro 3 hydroxyanthranilate Biochemistry 44 7623 763 ~~~
  6. Molecular Bases of Disease - Cell Biology:
    • Hao Yin,
    • Matthew J. Frontini,
    • John-Michael Arpino,
    • Zengxuan Nong,
    • Caroline O'Neil,
    • Yiwen Xu,
    • Brittany Balint,
    • Aaron D. Ward,
    • Subrata Chakrabarti,
    • Christopher G. Ellis,
    • Robert Gros,
    • and J. Geoffrey Pickering
    Fibroblast Growth Factor 9 Imparts Hierarchy and Vasoreactivity to the Microcirculation of Renal Tumors and Suppresses Metastases J. Biol. Chem. 2015 290: 22127-. doi:10.1074/jbc.M115.652222
    ...NAD biosynthesis J Cell Sci 125 5770 5780 26 Small T W Bolender Z Bueno C O Neil C Nong Z Rushlow W Rajakumar N Kandel C Strong J Madrenas J and Pickering J G 2006 Wilms tumor 1 associating protein regulates the proliferation of vascular smooth muscle cells ~~~
  7. Neurobiology - Molecular Bases of Disease:
    • Yo Sasaki,
    • Zachary Margolin,
    • Benjamin Borgo,
    • James J. Havranek,
    • and Jeffrey Milbrandt
    Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants J. Biol. Chem. 2015 290: 17228-. doi:10.1074/jbc.M115.637850
    ...NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 1010 1013 13 Sasaki Y Vohra B P Baloh R H and Milbrandt J 2009 Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo J Neurosci 29 6526 6534 14 Sasaki Y ~~~
  8. Metabolism - Genomics and Proteomics:
    • Bo Tan,
    • Sucai Dong,
    • Robert L. Shepard,
    • Lisa Kays,
    • Kenneth D. Roth,
    • Sandaruwan Geeganage,
    • Ming-Shang Kuo,
    • and Genshi Zhao
    Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells J. Biol. Chem. 2015 290: 15812-. doi:10.1074/jbc.M114.632141
    ...Inhibition of Nicotinamide Phosphoribosyltransferase NAMPT an Enzyme Essential for NAD Biosynthesis Leads to Altered Carbohydrate Metabolism in Cancer Cells Received for publication December 12 2014 and in revised form May 3 2015 Published JBC Papers in Press May 5 2015 DOI 10 1074 M ~~~
  9. Metabolism - Enzymology:
    • Fange Liu,
    • Jiafeng Geng,
    • Ryan H. Gumpper,
    • Arghya Barman,
    • Ian Davis,
    • Andrew Ozarowski,
    • Donald Hamelberg,
    • and Aimin Liu
    An Iron Reservoir to the Catalytic Metal: THE RUBREDOXIN IRON IN AN EXTRADIOL DIOXYGENASE J. Biol. Chem. 2015 290: 15621-. doi:10.1074/jbc.M115.650259
    ...NAD biosynthesis identification of the tryptophan to quinolinate pathway in bacteria Chem Biol 10 1195 1204 9 Zhang Y Colabroy K L Begley T P and Ealick S E 2005 Structural studies on 3 hydroxyanthranilate 3 4 dioxygenase the catalytic mechanism of a complex oxidation involved ~~~
  10. Molecular Bases of Disease - Protein Structure and Folding:
    • Hilda Mirbaha,
    • Brandon B. Holmes,
    • David W. Sanders,
    • Jan Bieschke,
    • and Marc I. Diamond
    Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation J. Biol. Chem. 2015 290: 14893-. doi:10.1074/jbc.M115.652693
    ...complementation assays Chem Biol 17 1018 1029 19 Araki T Sasaki Y and Milbrandt J 2004 Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration Science 305 1010 1013 20 Patterson K R Remmers C Fu Y Brooker S Kanaan N M Vana L Ward S Reyes J F ~~~
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