Searching journal content for copper transport (as phrase) in full text.

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  1. Microbiology - Developmental Biology:
    • Samuel Plante,
    • Vincent Normant,
    • Karla M. Ramos-Torres,
    • and Simon Labbé
    Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination J. Biol. Chem. 2017 292: 11896-. doi:10.1074/jbc.M117.794677
    ...-copper conditions, the copper transporters Ctr4 and Ctr5 are maximally expressed at the onset of outgrowth. In the case of Ctr6, its expression is broader, taking place before and during outgrowth. Spores lacking Ctr4, Ctr5, and the copper sensor Cuf1 exhibit complete germination arrest at outgrowth. In contrast ~~~
  2. Cell Biology - Metabolism:
    • Brandon L. Logeman,
    • L. Kent Wood,
    • Jaekwon Lee,
    • and Dennis J. Thiele
    Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 J. Biol. Chem. 2017 292: 11531-. doi:10.1074/jbc.M117.793356
    ...and is involved in a range of processes, including oxidative phosphorylation, neuropeptide biogenesis, and connective tissue maturation. The copper transporter (Ctr) family of integralmembrane proteins is ubiquitously found in eukaryotes and mediates the high-affinity transport of Cu across both ~~~
  3. Cell Biology - Metabolism:
    • Filip Liebsch,
    • Mark R. P. Aurousseau,
    • Tobias Bethge,
    • Hugo McGuire,
    • Silvia Scolari,
    • Andreas Herrmann,
    • Rikard Blunck,
    • Derek Bowie,
    • and Gerd Multhaup
    Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization J. Biol. Chem. jbc.M117.779165. doi:10.1074/jbc.M117.779165
    ...-2045 gerhard.multhaup@mcgill.ca Keywords: beta-secretase 1 (BACE1)/copper transport/stoichiometry/single-molecule biophysics/protein cross-linking ABSTRACT The beta-secretase (BACE1) initiates processing of the amyloid precursor protein (APP) into A peptides, which have been implicated as central players ~~~
  4. Molecular Biophysics - Protein Structure and Folding:
    • Morgan M. Fetherolf,
    • Stefanie D. Boyd,
    • Alexander B. Taylor,
    • Hee Jong Kim,
    • James A. Wohlschlegel,
    • Ninian J. Blackburn,
    • P. John Hart,
    • Dennis R. Winge,
    • and Duane D. Winkler
    Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site J. Biol. Chem. jbc.M117.775981. doi:10.1074/jbc.M117.775981
    ...copper transporter Ctr1 (Fig. 7C). This strongly suggests that sulfenylation at Sod1 C146 is a copper-mediated reaction. Additionally, Sod1 isolated from ccs1 cells is sulfenylated implying that the primary role of Ccs1 may not be in copper delivery. Sulfenylation at this site likely promotes C57-C146 ~~~
  5. Molecular Bases of Disease - Metabolism:
    • Stephen W. Mercer,
    • Jianbin Wang,
    • and Richard Burke
    In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease J. Biol. Chem. 2017 292: 4113-. doi:10.1074/jbc.M116.756163
    ...of individual ATP7A/B mutations in an invariant genetic background and has the potential to be used to screen for therapeutic compounds able to restore function to faulty copper transport proteins. IntroductionCopper is an essential trace element required as a cofactor for enzymes involved in numerous important ~~~
  6. Molecular Biophysics - Neurobiology:
    • Yang Li,
    • Felix P. Mayer,
    • Peter S. Hasenhuetl,
    • Verena Burtscher,
    • Klaus Schicker,
    • Harald H. Sitte,
    • Michael Freissmuth,
    • and Walter Sandtner
    Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism J. Biol. Chem. 2017 292: 4235-. doi:10.1074/jbc.M116.760140
    ...10, another manganese extruder, also gives rise to parkinsonism (15). Similarly, Wilsons disease is caused by a deficiency in the copper transporter ATP7B, which results in copper accumulation in the basal ganglia and produces, inter alia, Parkinsonian symptoms (16). Before the link between dopamine ~~~
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  7. Molecular Bases of Disease - Enzymology:
    • Hermeto Gerber,
    • Fang Wu,
    • Mitko Dimitrov,
    • Guillermo M. Garcia Osuna,
    • and Patrick C. Fraering
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production J. Biol. Chem. 2017 292: 3751-. doi:10.1074/jbc.M116.754101
    ...+ can reach extracellularly up to 300 m in the neuronal synaptic clefts (69) but that only a small percentage of A is produced at the plasma membrane (25, 26). Yet immunocytochemical studies have demonstrated that copper transporters are localized at the plasma membrane in HEK293 human embryonic ~~~
  8. Editors' Picks - Cell Biology - Metabolism:
    • Haarin Chun,
    • Anuj Kumar Sharma,
    • Jaekwon Lee,
    • Jefferson Chan,
    • Shang Jia,
    • and Byung-Eun Kim
    The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans J. Biol. Chem. 2017 292: 1-. doi:10.1074/jbc.M116.760876
    ...). In worms, transcriptional reporters have been used to detect cua-1 expression in several tissues, including the intestine. An essential role for cua-1 for copper transport in C. elegans has been suggested, as deletion of cua-1 results in embryonic lethality (18, 21). However, how CUA-1 in the intestine ~~~
  9. Plant Biology - Enzymology:
    • Emeline Sautron,
    • Cécile Giustini,
    • ThuyVan Dang,
    • Lucas Moyet,
    • Daniel Salvi,
    • Serge Crouzy,
    • Norbert Rolland,
    • Patrice Catty,
    • and Daphné Seigneurin-Berny
    Identification of Two Conserved Residues Involved in Copper Release from Chloroplast PIB-1-ATPases J. Biol. Chem. 2016 291: 20136-. doi:10.1074/jbc.M115.706978
    ...of the PIB-1-ATPases subfamily: HMA6 at the chloroplast envelope and HMA8 in the thylakoid membranes. Both proteins are high affinity copper transporters but share distinct enzymatic properties. In the present work, the comparison of 140 sequences of PIB-1-ATPases revealed a conserved region unusually rich ~~~
  10. Plant Biology:
    • Daniela Strenkert,
    • Clariss Ann Limso,
    • Abdelhak Fatihi,
    • Stefan Schmollinger,
    • Gilles J. Basset,
    • and Sabeeha S. Merchant
    Genetically Programmed Changes in Photosynthetic Cofactor Metabolism in Copper-deficient Chlamydomonas J. Biol. Chem. 2016 291: 19118-. doi:10.1074/jbc.M116.717413
    ...in Arabidopsis, SPL7, controls nutritional copper homeostasis as well (7, 8). Transcriptome experiments revealed multiple targets of this transcription factor in both organisms but besides the genes encoding assimilatory copper transporters (COPT/CTR), which are dramatically up-regulated in both organisms under ~~~
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