Searching journal content for articles similar to Weisshart et al. 269 (36): 22788.

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  1. Enzymology:
    • Frank J. P. Kühn and
    • Charles W. Knopf
    Herpes Simplex Virus Type 1 DNA Polymerase: MUTATIONAL ANALYSIS OF THE 3′-5′-EXONUCLEASE DOMAIN J. Biol. Chem. 1996 271: 29245-. doi:10.1074/jbc.271.46.29245
    ...Heidelberg, Federal Republic of Germany Like true DNA replicases, herpes simplex virus type 1 DNA polymerase is equipped with a proofreading 3*-5*exonuclease. In order to assess the functional significance of conserved residues in the putative exonuclease domain, we introduced point mutations as well...
  2. DNA: Replication, Repair, and Recombination:
    • Marina Mapelli,
    • Santosh Panjikar,
    • and Paul A. Tucker
    The Crystal Structure of the Herpes Simplex Virus 1 ssDNA-binding Protein Suggests the Structural Basis for Flexible, Cooperative Single-stranded DNA Binding J. Biol. Chem. 2005 280: 2990-. doi:10.1074/jbc.M406780200
    ...The Crystal Structure of the Herpes Simplex Virus 1 ssDNA binding Protein Suggests the Structural Basis for Flexible Cooperative Single stranded DNA Binding S Received for publication June 17 2004 and in revised form October 25 2004 Published JBC Papers in Press October 26 2004 DOI 10...
  3. Signal Transduction - Molecular Bases of Disease:
    • Aarthi Narayanan,
    • Kylene Kehn-Hall,
    • Svetlana Senina,
    • Lindsay Lundberg,
    • Rachel Van Duyne,
    • Irene Guendel,
    • Ravi Das,
    • Alan Baer,
    • Laura Bethel,
    • Michael Turell,
    • Amy Lynn Hartman,
    • Bhaskar Das,
    • Charles Bailey,
    • and Fatah Kashanchi
    Curcumin Inhibits Rift Valley Fever Virus Replication in Human Cells J. Biol. Chem. 2012 287: 33198-. doi:10.1074/jbc.M112.356535
    ...alteration in IKK could be observed in the case of an infection by a DNA virus To that end we utilized KSHV HHV 8 infected cells BCBL 1 and their uninfected counterparts BJAB 33 to perform a fractionation experiment similar to that with the RVFVinfected cells KSHV infection is known to activate...
  4. Nucleic Acids, Protein Synthesis, and Molecular Genetics:
    • Xiao-ming Yang and
    • Charles C. Richardson
    Structural and Functional Organization of the DNA Polymerase of Bacteriophage T7 J. Biol. Chem. 1996 271: 24207-. doi:10.1074/jbc.271.39.24207
    ...activity Subsequently in vitro mutagenesis has been used to physically separate the polymerase domain from the exonuclease domain 25 Limited proteolysis has also been used to show that the polymerase and exonuclease activities of bacteriophage T4 DNA polymerase and herpes simplex virus DNA...
    • E K Spicer,
    • J Rush,
    • C Fung,
    • L J Reha-Krantz,
    • J D Karam,
    • and W H Konigsberg
    Primary structure of T4 DNA polymerase. Evolutionary relatedness to eucaryotic and other procaryotic DNA polymerases. J. Biol. Chem. 1988 263: 7478-.
    ...the sequence of T4 DNA polymerase with other procaryotic and eucaryotic DNA polymerases Surprisingly T4 DNA po lymerase shares more sequence similarity with animal virus DNA polymerases than it does with those of procaryotic origin The location of specific mutations in herpes simplex virus DNA polymerase...
  6. Enzyme Catalysis and Regulation:
    • Júlia Kovári,
    • Orsolya Barabás,
    • Enikõ Takács,
    • Angéla Békési,
    • Zsófia Dubrovay,
    • Veronika Pongrácz,
    • Imre Zagyva,
    • Timea Imre,
    • Pál Szabó,
    • and Beáta G. Vértessy
    Altered Active Site Flexibility and a Structural Metal-binding Site in Eukaryotic dUTPase: KINETIC CHARACTERIZATION, FOLDING, AND CRYSTALLOGRAPHIC STUDIES OF THE HOMOTRIMERIC DROSOPHILA ENZYME J. Biol. Chem. 2004 279: 17932-. doi:10.1074/jbc.M313643200
    ...death 4 5 dUTPase is therefore reported to be a preventive DNA repair factor 6 essential in both prokaryotes 7 and eukaryotes 8 and a key determinant of viral host cell range and infectivity of Herpes simplex virus 9 as well as several retroviruses 10 12 Drugs targeting enzymes of de...
    • T C Lin,
    • G Karam,
    • and W H Konigsberg
    Isolation, characterization, and kinetic properties of truncated forms of T4 DNA polymerase that exhibit 3'-5' exonuclease activity. J. Biol. Chem. 1994 269: 19286-.
    ...of a functional Klenow fragment pol domain without exo activity has been reported 12 With both the T4 and the herpes simplex virus HSV DNA polymerases there is some evidence suggesting that the structure of the exo domain affects the activity of the pol domain For example i particular point mutations...
    • M B Slabaugh,
    • R E Davis,
    • N A Roseman,
    • and C K Mathews
    Vaccinia virus ribonucleotide reductase expression and isolation of the recombinant large subunit. J. Biol. Chem. 1993 268: 17803-.
    ...This activity is the only de novo route to deoxyribonucleotides and is thus a necessary enzyme in DNA synthesis reviewed in Stubbe 1990 Whether the virus encoded enzymes are es sential for viral replication has been tested in herpes simplex and vaccinia viruses by engineering mutants Goldstein...
    • S E Bennett and
    • D W Mosbaugh
    Characterization of the Escherichia coli uracil-DNA glycosylase.inhibitor protein complex. J. Biol. Chem. 1992 267: 22512-21.
    ...and herpes simplex virus 12 have been reported Significant amino acid similarity based on the nucleotide sequence of the genes between E coli yeast herpes viruses and human placental uracil DNA glycosylase 40 55 identical residues has been recognized 2 9 How ever recent reports...
  10. Protein Chemistry and Structure:
    • Russell J. Sanderson and
    • Dale W. Mosbaugh
    Identification of Specific Carboxyl Groups on Uracil-DNA Glycosylase Inhibitor Protein That Are Required for Activity J. Biol. Chem. 1996 271: 29170-. doi:10.1074/jbc.271.46.29170
    ...://www-.stanford.edu//29170 plexed to the human (4, 21) and herpes simplex virus type I (22) uracil-DNA glycosylases revealed interactions between Ugi and conserved amino acids near the active site of the enzyme, suggesting protein mimicry of DNA. Recently, the secondary and tertiary structures of Ugi were determined...
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