Searching journal content for articles similar to Mizokami and Chang 269 (41): 25655.

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  1. Molecular Bases of Disease - Cell Biology:
    • Harris S. Soifer,
    • Naira Souleimanian,
    • Sijian Wu,
    • Anatoliy M. Voskresenskiy,
    • Filiz Kisaayak Collak,
    • Bekir Cinar,
    • and Cy A. Stein
    Direct Regulation of Androgen Receptor Activity by Potent CYP17 Inhibitors in Prostate Cancer Cells J. Biol. Chem. 2012 287: 3777-. doi:10.1074/jbc.M111.261933
    ...of prostate cell growth by 17 HASs still remains elusive Here we assess the effects of 17 HASs on androgen receptor AR activity in LNCaP and LAPC 4 cells We demonstrate that both TOK 001 and abiraterone reduced AR protein and mRNA expression and antagonized AR dependent promoter activation induced...
  2. Signal Transduction - Molecular Bases of Disease:
    • Nagalakshmi Nadiminty,
    • Ramakumar Tummala,
    • Wei Lou,
    • Yezi Zhu,
    • Jin Zhang,
    • Xinbin Chen,
    • Ralph W. deVere White,
    • Hsing-Jien Kung,
    • Christopher P. Evans,
    • and Allen C. Gao
    MicroRNA let-7c Suppresses Androgen Receptor Expression and Activity via Regulation of Myc Expression in Prostate Cancer Cells J. Biol. Chem. 2012 287: 1527-. doi:10.1074/jbc.M111.278705
    ...RNAs miRNAs are endogenous small non coding RNAs that interfere with protein expression either by inducing cleavage of their specific target mRNAs or by inhibiting their translation MiRNAs have been shown to regulate a rapidly increasing list of complex biological processes including differentiation...
  3. RNA-Mediated Regulation and Noncoding RNA:
    • Neville J. Butcher,
    • Gysell M. Broadhurst,
    • and Rodney F. Minchin
    Polyamine-dependent Regulation of Spermidine-Spermine N1-Acetyltransferase mRNA Translation J. Biol. Chem. 2007 282: 28530-. doi:10.1074/jbc.M701265200
    ...for maintaining polyamine homeostasis The presence of SSAT mRNA in a translationally repressed state means that the cell can respond quickly to restore polyamine homeostasis following an elevation in their levels If endogenous polyamines regulate SSAT translation stimuli that increase SSAT transcription would...
  4. RNA-Mediated Regulation and Noncoding RNAs:
    • Michael R. Epis,
    • Keith M. Giles,
    • Andrew Barker,
    • Tulene S. Kendrick,
    • and Peter J. Leedman
    miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer J. Biol. Chem. 2009 284: 24696-. doi:10.1074/jbc.M109.030098
    ...with miR 331 3p reduced ERBB 2 mRNA and protein expression and blocked downstream phosphatidylinositol 3 kinase AKT signaling Furthermore miR 331 3p transfection blocked the androgen receptor signaling pathway in prostate cancer cells reducing activity of an androgen stimulated prostate specific...
  5. Genes: Structure and Regulation:
    • Andrew M. Thomson,
    • Catherine M. Cahill,
    • Hyun-Hee Cho,
    • Kristin D. Kassachau,
    • Michael R. Epis,
    • Kenneth R. Bridges,
    • Peter J. Leedman,
    • and Jack T. Rogers
    The Acute Box cis-Element in Human Heavy Ferritin mRNA 5′-Untranslated Region Is a Unique Translation Enhancer That Binds Poly(C)-binding Proteins J. Biol. Chem. 2005 280: 30032-. doi:10.1074/jbc.M502951200
    ...The Acute Box cis Element in Human Heavy Ferritin mRNA 5 Untranslated Region Is a Unique Translation Enhancer That Binds Poly C binding Proteins S Received for publication March 17 2005 and in revised form June 20 2005 Published JBC Papers in Press June 20 2005 DOI 10 1074 M502951200...
  6. RNA: Processing and Catalysis:
    • Harryl D. Martinez,
    • Rohini J. Jasavala,
    • Izumi Hinkson,
    • Latricia D. Fitzgerald,
    • James S. Trimmer,
    • Hsing-Jien Kung,
    • and Michael E. Wright
    RNA Editing of Androgen Receptor Gene Transcripts in Prostate Cancer Cells J. Biol. Chem. 2008 283: 29938-. doi:10.1074/jbc.M800534200
    ...for optimal growth in vitro thus demonstrating each cell line is a bona fide model of androgen responsive AR dependent CaP We show AR gene transcripts in DU145 and PC3 cells harbor nucleotide transitions suggesting the AR pre mRNA is the target of multiple RNA editing enzymes We propose that RNA editing...
  7. RNA: Structure, Metabolism, and Catalysis:
    • Amar Thyagarajan and
    • Ben G. Szaro
    Phylogenetically Conserved Binding of Specific K Homology Domain Proteins to the 3′-Untranslated Region of the Vertebrate Middle Neurofilament mRNA J. Biol. Chem. 2004 279: 49680-. doi:10.1074/jbc.M408915200
    ...which include changes in mRNA stability 9 10 as well as in translation and localization 11 13 Aberrant post transcriptional regulation of nIF expression plays a role in a number of neurodegenerative disorders including amyotrophic lateral sclerosis 14 In eukaryotes the 3 untranslated region...
  8. RNA: STRUCTURE METABOLISM AND CATALYSIS:
    • Bu B. Yeap,
    • Dominic C. Voon,
    • Julian P. Vivian,
    • Ross K. McCulloch,
    • Andrew M. Thomson,
    • Keith M. Giles,
    • Maria F. Czyzyk-Krzeska,
    • Henry Furneaux,
    • Matthew C. J. Wilce,
    • Jackie A. Wilce,
    • and Peter J. Leedman
    Novel Binding of HuR and Poly(C)-binding Protein to a Conserved UC-rich Motif within the 3′-Untranslated Region of the Androgen Receptor Messenger RNA J. Biol. Chem. 2002 277: 27183-. doi:10.1074/jbc.M202883200
    ...that target the highly conserved UC rich region The binding of HuR CP1 and CP2 to AR mRNA suggests a role for each of these proteins in the post transcriptional regulation of AR expression in cancer cells The interaction between androgens such as dihydrotestosterone DHT 1 and the androgen receptor AR...
  9. Transcription, Chromatin, and Epigenetics:
    • Tasneem Bawa-Khalfe,
    • Jinke Cheng,
    • Zhengxin Wang,
    • and Edward T. H. Yeh
    Induction of the SUMO-specific Protease 1 Transcription by the Androgen Receptor in Prostate Cancer Cells J. Biol. Chem. 2007 282: 37341-. doi:10.1074/jbc.M706978200
    ...PC 3 cells indicating an androgen receptor dependent event Activation of the androgen receptor was required for binding an identified androgen response element and positively regulating SENP1 promoter activity Abrogation of elevated SENP1 mRNA in prostate cancer cells significantly decreased...
  10. RNA: Structure, Metabolism, and Catalysis:
    • David J. Adams,
    • Dianne J. Beveridge,
    • Louise van der Weyden,
    • Helena Mangs,
    • Peter J. Leedman,
    • and Brian J. Morris
    HADHB, HuR, and CP1 Bind to the Distal 3′-Untranslated Region of Human Renin mRNA and Differentially Modulate Renin Expression J. Biol. Chem. 2003 278: 44894-. doi:10.1074/jbc.M307782200
    ...have recently observed HuR binding to nonclassical ARE ciselements in the androgen receptor and p21WAF1 mRNAs 26 27 For REN mRNA HuR could play a critical role in mRNA stabilization in the nucleus However a role in facilitating transport from the nucleus to the cytoplasm for translation...
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