Searching journal content for articles similar to Uelhoff et al. 280 (7): 5137.

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  1. Computational Biology - Protein Structure and Folding:
    • Yiming Wang,
    • Qing Shao,
    • and Carol K. Hall
    N-terminal Prion Protein Peptides (PrP(120–144)) Form Parallel In-register β-Sheets via Multiple Nucleation-dependent Pathways J. Biol. Chem. 2016 291: 22093-. doi:10.1074/jbc.M116.744573
    ...-Sträussler-Scheinker syndrome-like prion disease characterized by the presence of amyloid deposits in the cerebral nervous system (10). Vanik et al. (11) found that recombinant PrP(23–144) from human, mouse, and hamster form fibrils with distinct lag phases. They concluded that species-specific mutations (I138M and I139M...
  2. Protein Structure and Folding - Molecular Bases of Disease:
    • Bradley R. Groveman,
    • Allison Kraus,
    • Lynne D. Raymond,
    • Michael A. Dolan,
    • Kelsie J. Anson,
    • David W. Dorward,
    • and Byron Caughey
    Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrPSc-like Folding of Recombinant PrP Amyloids J. Biol. Chem. 2015 290: 1119-. doi:10.1074/jbc.M114.619627
    ...Charge Neutralization of the Central Lysine Cluster in Prion Protein (PrP) Promotes PrPSc-like Folding of Recombinant PrP Amyloids* Received for publication,October 16, 2014, and in revised form, November 20, 2014 Published, JBC Papers in Press,November 21, 2014, DOI 10.1074/.M114.619627 Bradley R...
  3. Molecular Bases of Disease - Glycobiology and Extracellular Matrices:
    • Saurabh Srivastava,
    • Elizaveta Katorcha,
    • Martin L. Daus,
    • Peter Lasch,
    • Michael Beekes,
    • and Ilia V. Baskakov
    Sialylation Controls Prion Fate in Vivo J. Biol. Chem. 2017 292: 2359-. doi:10.1074/jbc.M116.768010
    .... To analyze changes in sialylation status, brain-, PMCAb-, and dsPMCAb-derived materials were treated with PK to remove any remaining PrPC, then denatured into PrP monomers, and the sialylation status of individual PrP molecules was analyzed by 2D Western blots. In agreement with previous studies (28, 29...
  4. Cell Biology - Membrane Biology:
    • Liheng Yang,
    • Zhenxing Gao,
    • Lipeng Hu,
    • Guiru Wu,
    • Xiaowen Yang,
    • Lihua Zhang,
    • Ying Zhu,
    • Boon-Seng Wong,
    • Wei Xin,
    • Man-Sun Sy,
    • and Chaoyang Li
    Glycosylphosphatidylinositol Anchor Modification Machinery Deficiency Is Responsible for the Formation of Pro-Prion Protein (PrP) in BxPC-3 Protein and Increases Cancer Cell Motility J. Biol. Chem. 2016 291: 3905-. doi:10.1074/jbc.M115.705830
    ...430071, Hubei, China. Tel.: 86-27-87198670; E-mail: cyli@wh.iov.cn. AbstractThe normal cellular prion protein (PrP) is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein. However, in pancreatic ductal adenocarcinoma cell lines, such as BxPC-3, PrP exists as a pro-PrP retaining its...
  5. Molecular Bases of Disease - Neurobiology:
    • Ilan Margalith,
    • Carlo Suter,
    • Boris Ballmer,
    • Petra Schwarz,
    • Cinzia Tiberi,
    • Tiziana Sonati,
    • Jeppe Falsig,
    • Sofie Nyström,
    • Per Hammarström,
    • Andreas Åslund,
    • K. Peter R. Nilsson,
    • Alice Yam,
    • Eric Whitters,
    • Simone Hornemann,
    • and Adriano Aguzzi
    Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates J. Biol. Chem. 2012 287: 18872-. doi:10.1074/jbc.M112.355958
    ...Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein PrP Aggregates S Received for publication February 27 2012 and in revised form April 4 2012 Published JBC Papers in Press April 6 2012 DOI 10 1074 M112 355958 Ilan Margalith Carlo Suter Boris Ballmer Petra...
  6. Methods and Resources - Neurobiology:
    • Boris A. Ballmer,
    • Rita Moos,
    • Prisca Liberali,
    • Lucas Pelkmans,
    • Simone Hornemann,
    • and Adriano Aguzzi
    Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay J. Biol. Chem. 2017 292: 8356-. doi:10.1074/jbc.M116.773283
    ...in endosomal sorting of cell-surface receptors (40), an increased endocytosis rate and reduced PrPC cell-surface expression was found. Silencing of GIT2, a gene that encodes the ARF GTPase-activating protein GIT2 (41), increased the uptake of PrPC without affecting PrP cell-surface level (Fig. 7). Hence, we...
  7. Protein Structure and Folding - Molecular Bases of Disease:
    • Bradley R. Groveman,
    • Michael A. Dolan,
    • Lara M. Taubner,
    • Allison Kraus,
    • Reed B. Wickner,
    • and Byron Caughey
    Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids J. Biol. Chem. 2014 289: 24129-. doi:10.1074/jbc.M114.578344
    ...Parallel In register Intermolecular Sheet Architectures for Prion seeded Prion Protein PrP Amyloids S Received for publication May 2 2014 and in revised form June 26 2014 Published JBC Papers in Press July 15 2014 DOI 10 1074 M114 578344 Bradley R Groveman 1 Michael A Dolan 1 Lara...
  8. Neurobiology - Cell Biology:
    • Clive Bate,
    • William Nolan,
    • and Alun Williams
    Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation J. Biol. Chem. 2016 291: 160-. doi:10.1074/jbc.M115.672394
    ...local membrane microenvironments that are important in PrP-mediated cell signaling and PrPSc formation. These results suggest that pharmacological modification of GPI glycosylation might constitute a novel therapeutic approach to prion diseases. IntroductionThe prion diseases are fatal neurodegenerative...
  9. Microbiology - Immunology:
    • Xianzhu Wu,
    • Kiran K Dayanand,
    • Ramesh P Thylur,
    • Christopher C Norbury,
    • and D. Channe Gowda
    Small molecule-based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes J. Biol. Chem. jbc.M116.770313. doi:10.1074/jbc.M116.770313
    ...Small molecule–based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes* Xianzhu Wu‡, Kiran K. Dayanand‡, Ramesh P. Thylur‡, Christopher C. Norbury§, and D. Channe Gowda‡,1 From the ‡Department of Biochemistry...
  10. Molecular Bases of Disease - Gene Regulation:
    • Ryoji Fujiki,
    • Atsushi Hijikata,
    • Tsuyoshi Shirai,
    • Satoshi Okada,
    • Masao Kobayashi,
    • and Osamu Ohara
    Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation J. Biol. Chem. 2017 292: 6240-. doi:10.1074/jbc.M116.753848
    ...understand the impact of these pathogenic mutations. We constructed STAT1 alanine mutants of the α3 helix residues of the coiled-coil domain, which are frequently found in CMC pathogenic mutations, and measured their transcriptional activities. Most of the identified GOF residues were located inside...
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