50 Most Frequently Cited Articles: Greatest Hits

Rankings are based on citations to all JBC articles, from HighWire-hosted journals.

  1. PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

    Oliver H. Lowry, Nira J. Rosebrough, A. Lewis Farr, and Rose J. Randall

    J. Biol. Chem. 1951 193: 265.

  2. A new generation of Ca2+ indicators with greatly improved fluorescence properties

    G Grynkiewicz, M Poenie, and R Y Tsien

    J. Biol. Chem. 1985 260: 3440.

  3. A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

    Jordi Folch, M. Lees, and G. H. Sloane Stanley

    J. Biol. Chem. 1957 226: 497.

  4. PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

    Dario R. Alessi, Ana Cuenda, Philip Cohen, David T. Dudley, and Alan R. Saltiel

    J. Biol. Chem. 1995 270: 27489. doi:10.1074/jbc.270.46.27489

  5. Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

    Margaret F. Favata, Kurumi Y. Horiuchi, Elizabeth J. Manos, Andrea J. Daulerio, Deborah A. Stradley, Wendi S. Feeser, Drew E. Van Dyk, William J. Pitts, Richard A. Earl, Frank Hobbs, Robert A. Copeland, Ronald L. Magolda, Peggy A. Scherle, and James M. Trzaskos

    J. Biol. Chem. 1998 273: 18623. doi:10.1074/jbc.273.29.18623

  6. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

    C J Vlahos, W F Matter, K Y Hui, and R F Brown

    J. Biol. Chem. 1994 269: 5241.

  7. High resolution two-dimensional electrophoresis of proteins

    P H O'Farrell

    J. Biol. Chem. 1975 250: 4007.

  8. DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

    Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr, Vessela S. Ivanova, and William M. Bonner

    J. Biol. Chem. 1998 273: 5858. doi:10.1074/jbc.273.10.5858

  9. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

    D Toullec, P Pianetti, H Coste, P Bellevergue, T Grand-Perret, M Ajakane, V Baudet, P Boissin, E Boursier, and F Loriolle

    J. Biol. Chem. 1991 266: 15771.

  10. Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor: STUDY OF Lck- AND FynT-DEPENDENT T CELL ACTIVATION

    Jeffrey H. Hanke, Joseph P. Gardner, Robert L. Dow, Paul S. Changelian, William H. Brissette, Elora J. Weringer, Brian A. Pollok, and Patricia A. Connelly

    J. Biol. Chem. 1996 271: 695. doi:10.1074/jbc.271.2.695

  11. Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

    Joël Raingeaud, Shashi Gupta, Jeffrey S. Rogers, Martin Dickens, Jiahuai Han, Richard J. Ulevitch, and Roger J. Davis

    J. Biol. Chem. 1995 270: 7420. doi:10.1074/jbc.270.13.7420

  12. The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

    Michael Karin

    J. Biol. Chem. 1995 270: 16483. doi:10.1074/jbc.270.28.16483

  13. Superoxide Dismutase: AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)

    Joe M. McCord and Irwin Fridovich

    J. Biol. Chem. 1969 244: 6049.

  14. The Carbon Monoxide-binding Pigment of Liver Microsomes: I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

    Tsuneo Omura and Ryo Sato

    J. Biol. Chem. 1964 239: 2370.

  15. Matrix Metalloproteinases

    Hideaki Nagase and J. Frederick Woessner, Jr.

    J. Biol. Chem. 1999 274: 21491. doi:10.1074/jbc.274.31.21491

  16. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

    Tomohiko Maehama and Jack E. Dixon

    J. Biol. Chem. 1998 273: 13375. doi:10.1074/jbc.273.22.13375

  17. An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

    Jürgen M. Lehmann, Linda B. Moore, Tracey A. Smith-Oliver, William O. Wilkison, Timothy M. Willson, and Steven A. Kliewer

    J. Biol. Chem. 1995 270: 12953. doi:10.1074/jbc.270.22.12953

  18. The mitogen-activated protein kinase signal transduction pathway

    R J Davis

    J. Biol. Chem. 1993 268: 14553.

  19. Glutathione S-Transferases: THE FIRST ENZYMATIC STEP IN MERCAPTURIC ACID FORMATION

    William H. Habig, Michael J. Pabst, and William B. Jakoby

    J. Biol. Chem. 1974 249: 7130.

  20. The Regulation of Rabbit Skeletal Muscle Contraction: I. BIOCHEMICAL STUDIES OF THE INTERACTION OF THE TROPOMYOSIN-TROPONIN COMPLEX WITH ACTIN AND THE PROTEOLYTIC FRAGMENTS OF MYOSIN

    James A. Spudich and Susan Watt

    J. Biol. Chem. 1971 246: 4866.

  21. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

    G Martiny-Baron, M G Kazanietz, H Mischak, P M Blumberg, G Kochs, H Hug, D Marmé, and C Schächtele

    J. Biol. Chem. 1993 268: 9194-7.

  22. How MAP Kinases Are Regulated

    Melanie H. Cobb and Elizabeth J. Goldsmith

    J. Biol. Chem. 1995 270: 14843. doi:10.1074/jbc.270.25.14843

  23. Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

    Mutsuki Amano, Masaaki Ito, Kazushi Kimura, Yuko Fukata, Kazuyasu Chihara, Takeshi Nakano, Yoshiharu Matsuura, and Kozo Kaibuchi

    J. Biol. Chem. 1996 271: 20246. doi:10.1074/jbc.271.34.20246

  24. Genistein, a specific inhibitor of tyrosine-specific protein kinases

    T Akiyama, J Ishida, S Nakagawa, H Ogawara, S Watanabe, N Itoh, M Shibuya, and Y Fukami

    J. Biol. Chem. 1987 262: 5592.

  25. Phosphorus Assay in Column Chromatography

    Grant R. Bartlett

    J. Biol. Chem. 1959 234: 466.

  26. THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

    Cyrus H. Fiske and Yellapragada Subbarow

    J. Biol. Chem. 1925 66: 375.

  27. A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B: FUNCTIONAL RELATIONSHIPS ESTABLISHED FOR KEY MEDIATORS OF APOPTOSIS

    Nancy A. Thornberry, Thomas A. Rano, Erin P. Peterson, Dita M. Rasper, Tracy Timkey, Margarita Garcia-Calvo, Vicky M. Houtzager, Penny A. Nordstrom, Sophie Roy, John P. Vaillancourt, Kevin T. Chapman, and Donald W. Nicholson

    J. Biol. Chem. 1997 272: 17907. doi:10.1074/jbc.272.29.17907

  28. Phase separation of integral membrane proteins in Triton X-114 solution

    C Bordier

    J. Biol. Chem. 1981 256: 1604.

  29. Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2

    Ralf Schwandner, Roman Dziarski, Holger Wesche, Mike Rothe, and Carsten J. Kirschning

    J. Biol. Chem. 1999 274: 17406. doi:10.1074/jbc.274.25.17406

  30. Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts

    Deborah A. Brown and Erwin London

    J. Biol. Chem. 2000 275: 17221. doi:10.1074/jbc.R000005200

  31. Angiogenesis

    J Folkman and Y Shing

    J. Biol. Chem. 1992 267: 10931.

  32. Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

    Jesse C. Chow, Donna W. Young, Douglas T. Golenbock, William J. Christ, and Fabian Gusovsky

    J. Biol. Chem. 1999 274: 10689. doi:10.1074/jbc.274.16.10689

  33. A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes

    Philipp E. Scherer, Suzanne Williams, Michael Fogliano, Giulia Baldini, and Harvey F. Lodish

    J. Biol. Chem. 1995 270: 26746. doi:10.1074/jbc.270.45.26746

  34. Structural features in eukaryotic mRNAs that modulate the initiation of translation

    M Kozak

    J. Biol. Chem. 1991 266: 19867-70.

  35. Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

    Takashi Okamoto, Amnon Schlegel, Philipp E. Scherer, and Michael P. Lisanti

    J. Biol. Chem. 1998 273: 5419. doi:10.1074/jbc.273.10.5419

  36. Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway: REQUIREMENT FOR Flk-1/KDR ACTIVATION

    Hans-Peter Gerber, Amy McMurtrey, Joe Kowalski, Minhong Yan, Bruce A. Keyt, Vishva Dixit, and Napoleone Ferrara

    J. Biol. Chem. 1998 273: 30336. doi:10.1074/jbc.273.46.30336

  37. The insulin signaling system

    M F White and C R Kahn

    J. Biol. Chem. 1994 269: 1.

  38. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor

    J Waltenberger, L Claesson-Welsh, A Siegbahn, M Shibuya, and C H Heldin

    J. Biol. Chem. 1994 269: 26988.

  39. p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

    Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark, Andreas Brech, Jack-Ansgar Bruun, Heidi Outzen, Aud Øvervatn, Geir Bjørkøy, and Terje Johansen

    J. Biol. Chem. 2007 282: 24131. doi:10.1074/jbc.M702824200

  40. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase

    Q W Xie, Y Kashiwabara, and C Nathan

    J. Biol. Chem. 1994 269: 4705.

  41. Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

    William L. Smith, R. Michael Garavito, and David L. DeWitt

    J. Biol. Chem. 1996 271: 33157. doi:10.1074/jbc.271.52.33157

  42. DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION

    Allan G. Gornall, Charles J. Bardawill, and Maxima M. David

    J. Biol. Chem. 1949 177: 751.

  43. Protein Kinase C: Structure, Function, and Regulation

    Alexandra C. Newton

    J. Biol. Chem. 1995 270: 28495. doi:10.1074/jbc.270.48.28495

  44. ACETYLORNITHINASE OF ESCHERICHIA COLI: PARTIAL PURIFICATION AND SOME PROPERTIES

    Henry J. Vogel and David M. Bonner

    J. Biol. Chem. 1956 218: 97.

  45. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A

    M Yoshida, M Kijima, M Akita, and T Beppu

    J. Biol. Chem. 1990 265: 17174.

  46. Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase: ISOLATION OF THE ACTIVATED FORM OF THE MEMBRANE METALLOPROTEASE

    Alex Y. Strongin, Ivan Collier, Gregory Bannikov, Barry L. Marmer, Gregory A. Grant, and Gregory I. Goldberg

    J. Biol. Chem. 1995 270: 5331. doi:10.1074/jbc.270.10.5331

  47. Co-purification and Direct Interaction of Ras with Caveolin, an Integral Membrane Protein of Caveolae Microdomains: DETERGENT-FREE PURIFICATION OF CAVEOLAE MEMBRANES

    Kenneth S. Song, Shengwen Li, Takashi Okamoto, Lawrence A. Quilliam, Massimo Sargiacomo, and Michael P. Lisanti

    J. Biol. Chem. 1996 271: 9690. doi:10.1074/jbc.271.16.9690

  48. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells

    T Chijiwa, A Mishima, M Hagiwara, M Sano, K Hayashi, T Inoue, K Naito, T Toshioka, and H Hidaka

    J. Biol. Chem. 1990 265: 5267.

  49. Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

    Aimee D. Kohn, Scott A. Summers, Morris J. Birnbaum, and Richard A. Roth

    J. Biol. Chem. 1996 271: 31372. doi:10.1074/jbc.271.49.31372

  50. An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

    Hua Zou, Yuchen Li, Xuesong Liu, and Xiaodong Wang

    J. Biol. Chem. 1999 274: 11549. doi:10.1074/jbc.274.17.11549

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