DNA and Chromosomes
Evidence That the DNA Mismatch Repair System Removes 1-Nucleotide Okazaki Fragment Flaps
Background: The DNA mismatch repair (MMR) system protects humans from cancer.Results: Combining an MMR system defect (msh2Δ) with rad27Δ causes a strong synergistic increase in the rate of 1-bp insertions, and a reconstituted MMR system removes 1-nt flaps.Conclusion: The MMR system removes 1-nt Okazaki fragment flaps.Significance: A new function of the MMR system was identified.
