DNA and Chromosomes
Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2
Background: The DNA mismatch repair protein MutS homolog 2 (MSH2) is an acetylated protein.Results: Histone deacetylase 10 (HDAC10) interacts with MSH2 and deacetylates MSH2 at Lys-73, which might stimulate MSH2 activity.Conclusion: HDAC10 promotes DNA mismatch repair activity and may involve the deacetylation of MSH2.Significance: HDAC10 has an important role in regulating DNA mismatch repair.Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA
3′ repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease. Purified TREX1 displays robust exoribonuclease activity that degrades single-stranded, but not double-stranded, RNA. TREX1-D200N, an Aicardi-Goutieres syndrome disease-causing mutant, is defective in degrading RNA. TREX1 activity is strongly inhibited by a stretch of pyrimidine residues as is a bacterial homolog, RNase T.
