Enzymology
Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide
Background: Hydrogen sulfide (H2S) modulates physiological processes in mammals.Results: The reactivity of H2S toward disulfides (RSSR) and albumin sulfenic acid (RSOH) to form persulfides (RSSH) was assessed.Conclusion: H2S is less reactive than thiols. Persulfides have enhanced nucleophilicity.Significance: This kinetic study helps rationalize the contribution of the reactions with oxidized thiol derivatives to H2S biology.
