Gene Regulation
Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation
Background: CD36 plays a role in lipid uptake, foam cell formation, and atherogenesis.Results: 15(S)-HETE induces CD36 expression and foam cell formation by triggering p300-mediated STAT1 acetylation and its interaction with PPARγ.Conclusion: STAT1 and PPARγ interact with each other in CD36 expression and foam cell formation.Significance: 15(S)-HETE appears to play an important role in foam cell formation, a critical event in atherogenesis.
