x
Filter:
Filters applied
- Gene Regulation
- Igarashi, KazuhikoRemove Igarashi, Kazuhiko filter
- Nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2)Remove Nuclear factor 2 (erythroid-derived 2-like factor) (NFE2L2) (Nrf2) filter
Gene Regulation
1 Results
- Gene RegulationOpen Access
Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
Journal of Biological ChemistryVol. 292Issue 18p7519–7530Published online: March 17, 2017- Md. Morshedul Alam
- Keito Okazaki
- Linh Thi Thao Nguyen
- Nao Ota
- Hiroshi Kitamura
- Shohei Murakami
- and others
Cited in Scopus: 64NRF2 (nuclear factor erythroid 2-related factor 2) is a key transcriptional activator that mediates the inducible expression of antioxidant genes. NRF2 is normally ubiquitinated by KEAP1 (Kelch-like ECH-associated protein 1) and subsequently degraded by proteasomes. Inactivation of KEAP1 by oxidative stress or electrophilic chemicals allows NRF2 to activate transcription through binding to antioxidant response elements (AREs) and recruiting histone acetyltransferase CBP (CREB-binding protein). Whereas KEAP1-dependent regulation is a major determinant of NRF2 activity, NRF2-mediated transcriptional activation varies from context to context, suggesting that other intracellular signaling cascades may impact NRF2 function.