Gene Regulation
1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components
Background Vitamin D3 regulates intestinal calcium absorption to maintain mineral homeostasis. Results Genome-wide analyses reveal vitamin D3 target genes and their regulatory components in intestine. Conclusion A gene network involved in vitamin D3-mediated calcium uptake in the intestine is defined. Significance The network of genes provides a basis for understanding molecular mechanisms of vitamin D3-mediated active calcium transport in the intestine.
