Gene Regulation
Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells
Background: Expression of the vitamin D receptor (VDR) is regulated by hormones in a tissue-specific manner.Results: Enhancers potentially involved in the regulation of VDR expression were characterized in mouse tissues in vivo.Conclusion: Regulation of VDR expression is mediated by tissue-specific enhancers.Significance: Defining potential regulatory regions allows us to predict VDR expression in target tissues.
