Gene Regulation
Mechanisms of Enhancer-mediated Hormonal Control of Vitamin D Receptor Gene Expression in Target Cells
Background: Expression of the vitamin D receptor (VDR) is regulated by hormones in a tissue-specific manner.Results: Enhancers potentially involved in the regulation of VDR expression were characterized in mouse tissues in vivo.Conclusion: Regulation of VDR expression is mediated by tissue-specific enhancers.Significance: Defining potential regulatory regions allows us to predict VDR expression in target tissues.1,25-Dihydroxyvitamin D3 Controls a Cohort of Vitamin D Receptor Target Genes in the Proximal Intestine That Is Enriched for Calcium-regulating Components
Background Vitamin D3 regulates intestinal calcium absorption to maintain mineral homeostasis. Results Genome-wide analyses reveal vitamin D3 target genes and their regulatory components in intestine. Conclusion A gene network involved in vitamin D3-mediated calcium uptake in the intestine is defined. Significance The network of genes provides a basis for understanding molecular mechanisms of vitamin D3-mediated active calcium transport in the intestine.
