Glycobiology and Extracellular Matrices
Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation
Background: The functions of integrin α5 on cell proliferation and the underlying mechanisms remain unclear.Results: Loss of N-glycosylation on α5 increased the phosphorylation and internalization of EGFR and abolished its inhibitory effects on cell proliferation.Conclusion: Integrin α5 regulates EGFR-mediated signaling through N-glycosylation.Significance: N-Glycosylation plays important roles in the cross-talk between integrins and growth factor receptors.
