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Author
- Butchar, Jonathan P2
- Byrd, John C2
- Elavazhagan, Saranya2
- Fang, Huiqing2
- Fatehchand, Kavin2
- Gautam, Shalini2
- Mehta, Payal2
- Mo, Xiaokui2
- Reader, Brenda F2
- Tridandapani, Susheela2
- Benson, Don M Jr1
- Blachly, James S1
- Buteyn, Nathaniel J1
- Campbell, Amanda1
- McMichael, Elizabeth L1
- Merchand-Reyes, Giovanna1
- Ren, Li1
- Santhanam, Ramasamy1
- Stiff, Andrew1
- Vasu, Sumithira1
Immunology
2 Results
- ImmunologyOpen Access
Interferon-γ Promotes Antibody-mediated Fratricide of Acute Myeloid Leukemia Cells
Journal of Biological ChemistryVol. 291Issue 49p25656–25666Published online: October 25, 2016- Kavin Fatehchand
- Elizabeth L. McMichael
- Brenda F. Reader
- Huiqing Fang
- Ramasamy Santhanam
- Shalini Gautam
- and others
Cited in Scopus: 13Acute myeloid leukemia (AML) is characterized by the proliferation of immature myeloid lineage blasts. Due to its heterogeneity and to the high rate of acquired drug resistance and relapse, new treatment strategies are needed. Here, we demonstrate that IFNγ promotes AML blasts to act as effector cells within the context of antibody therapy. Treatment with IFNγ drove AML blasts toward a more differentiated state, wherein they showed increased expression of the M1-related markers HLA-DR and CD86, as well as of FcγRI, which mediates effector responses to therapeutic antibodies. - ImmunologyOpen Access
Analysis of the Effects of the Bruton's tyrosine kinase (Btk) Inhibitor Ibrutinib on Monocyte Fcγ Receptor (FcγR) Function
Journal of Biological ChemistryVol. 291Issue 6p3043–3052Published online: December 1, 2015- Li Ren
- Amanda Campbell
- Huiqing Fang
- Shalini Gautam
- Saranya Elavazhagan
- Kavin Fatehchand
- and others
Cited in Scopus: 54The irreversible Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has shown efficacy against B-cell tumors such as chronic lymphocytic leukemia and B-cell non-Hodgkin lymphoma. Fcγ receptors (FcγR) on immune cells such as macrophages play an important role in tumor-specific antibody-mediated immune responses, but many such responses involve Btk. Here we tested the effects of ibrutinib on FcγR-mediated activities in monocytes. We found that ibrutinib did not affect monocyte FcγR-mediated phagocytosis, even at concentrations higher than those achieved physiologically, but suppressed FcγR-mediated cytokine production.