Immunology
Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide
Background CD8+ T-cells play a central role in type 1 diabetes (T1D) by recognizing insulin peptides displayed by MHC. Results A novel flexible MHC binding mode accommodates extra C-terminal peptide residues. Conclusion Unusual peptide-MHC binding might explain weak TCR affinity of a natural T1D epitope. Significance MHC peptide binding can be highly flexible around the F-binding pocket.
