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Keyword
- adaptive immunity1
- antigen presentation1
- antigen recognition1
- cancer therapy1
- crystal structure1
- immuno-oncology1
- immunotherapy1
- MAGE-A41
- melanoma antigen-A4 (MAGE-A4)1
- peptide-human leukocyte antigen1
- peptide-human leukocyte antigen (pHLA)1
- surface plasmon resonance (SPR)1
- T cell receptor1
- T cell receptor (TCR)1
Immunology
1 Results
- ImmunologyOpen Access
T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4
Journal of Biological ChemistryVol. 295Issue 33p11486–11494Published online: June 12, 2020- Charlotte H. Coles
- Catriona McMurran
- Angharad Lloyd
- Miriam Hock
- Linda Hibbert
- Marine C.C. Raman
- and others
Cited in Scopus: 8T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for immunosurveillance and disease control. This interaction is generally stabilized by interactions between the HLA surface and TCR germline-encoded complementarity-determining region (CDR) loops 1 and 2, whereas peptide selectivity is guided by direct interactions with the TCR CDR3 loops. Here, we solved the structure of a newly identified TCR in complex with a clinically relevant peptide derived from the cancer testis antigen melanoma antigen-A4 (MAGE-A4).