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Immunology

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Glycobiology and Extracellular Matrices
Open Access
Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia
Journal of Biological Chemistry
Vol. 290Issue 35p21305–21319Published online: July 9, 2015
- Flaviana Di Lorenzo
- Łukasz Kubik
- Alja Oblak
- Nicola Ivan Lorè
- Cristina Cigana
- Rosa Lanzetta
- and others
Cited in Scopus: 43
Background: The Burkholderia cenocepacia lipid A is hypoacylated.Results: Aminoarabinose residues in lipid A contribute to Burkholderia lipid A binding to the TLR4·MD-2 complex.Conclusion: A novel mode of Burkholderia lipopolysaccharide-TLR4·MD-2 interactions promotes inflammation.Significance: Modifications of the lipid A structure enhance proinflammatory responses of hypoacylated lipopolysaccharide.