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Metabolism
2 Results
- Thematic MinireviewsOpen Access
Introduction to the Thematic Minireview Series: Redox metabolism and signaling
Journal of Biological ChemistryVol. 293Issue 20p7488–7489Published online: April 5, 2018- Ruma Banerjee
Cited in Scopus: 1In this sequel to the thematic collection of Minireviews on redox metabolism and signaling published last year, five articles plumb the redox metabolic pathways relevant to cell proliferation, stress response, and survival post-detachment from the extracellular matrix. The sixth article provides unexpected insights into the hepatic NAD(P)ome, revealing that more than half of these proteins reside outside the cytoplasmic and mitochondrial compartments, pointing to the paucity of knowledge on their functions. - MinireviewsOpen Access
Introduction to the Thematic Minireview Series: Redox metabolism and signaling
Journal of Biological ChemistryVol. 292Issue 41p16802–16803Published online: August 24, 2017- Ruma Banerjee
Cited in Scopus: 3Life on oxygen predisposes cells to reactive oxygen species (ROS) generation by electron slippage in the electron transfer chain. Aerobic metabolism also generates superoxide (O2̇̄) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electron reduction of O2. Although often viewed as dangerous, ROS are now recognized as important messengers in redox signaling pathways. A delicate balance between needed versus excessive ROS production distinguishes health from an array of disease states.
