- In this sequel to the thematic collection of Minireviews on redox metabolism and signaling published last year, five articles plumb the redox metabolic pathways relevant to cell proliferation, stress response, and survival post-detachment from the extracellular matrix. The sixth article provides unexpected insights into the hepatic NAD(P)ome, revealing that more than half of these proteins reside outside the cytoplasmic and mitochondrial compartments, pointing to the paucity of knowledge on their functions.
- Life on oxygen predisposes cells to reactive oxygen species (ROS) generation by electron slippage in the electron transfer chain. Aerobic metabolism also generates superoxide (O2̇̄) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electron reduction of O2. Although often viewed as dangerous, ROS are now recognized as important messengers in redox signaling pathways. A delicate balance between needed versus excessive ROS production distinguishes health from an array of disease states.