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Metabolism
2 Results
- MinireviewsOpen Access
Introduction to the Thematic Minireview Series: Redox metabolism and signaling
Journal of Biological ChemistryVol. 292Issue 41p16802–16803Published online: August 24, 2017- Ruma Banerjee
Cited in Scopus: 3Life on oxygen predisposes cells to reactive oxygen species (ROS) generation by electron slippage in the electron transfer chain. Aerobic metabolism also generates superoxide (O2̇̄) and hydrogen peroxide (H2O2) as bona fide products in reactions involving 1- or 2-electron reduction of O2. Although often viewed as dangerous, ROS are now recognized as important messengers in redox signaling pathways. A delicate balance between needed versus excessive ROS production distinguishes health from an array of disease states. - MinireviewsOpen Access
Introduction to the Thematic Minireview Series: Host-microbiome metabolic interplay
Journal of Biological ChemistryVol. 292Issue 21p8544–8545Published online: April 7, 2017- Ruma Banerjee
Cited in Scopus: 7Long before the recent thrust of scientific research on the microbiome, the importance of its interface with the host was being acknowledged by practices such as probiotic supplementation, e.g. after a course of antibiotics, which has the unwanted side effect of depleting commensal bacteria. The shared metabolite capital between the host and the microbiome is extensive and tightly controlled. However, despite the influence of microbe-derived metabolites on many aspects of host physiology, behavior, and pathology, our understanding of this metabolic interface is still in its infancy and its therapeutic targeting is largely untapped.
