Microbiology
Yeast Tolerance to Various Stresses Relies on the Trehalose-6P Synthase (Tps1) Protein, Not on Trehalose
Background: Decades of observations strengthened the idea that trehalose is a chemical chaperone.Results: A catalytically inactive variant of the trehalose-6P synthase (Tps1) maintains cell survival and energy homeostasis under stress exposure.Conclusion: The Tps1 protein itself, not trehalose, is crucial for cell integrity.Significance: This work provides unbiased evidence for an alternative function of Tps1, a new “moonlighting” protein.
