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- fungi2
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Microbiology
2 Results
- Research ArticleOpen Access
Cryptococcus neoformans melanization incorporates multiple catecholamines to produce polytypic melanin
Journal of Biological ChemistryVol. 298Issue 1101519Published online: December 20, 2021- Rosanna P. Baker
- Christine Chrissian
- Ruth E. Stark
- Arturo Casadevall
Cited in Scopus: 3Melanin is a major virulence factor in pathogenic fungi that enhances the ability of fungal cells to resist immune clearance. Cryptococcus neoformans is an important human pathogenic fungus that synthesizes melanin from exogenous tissue catecholamine precursors during infection, but the type of melanin made in cryptococcal meningoencephalitis is unknown. We analyzed the efficacy of various catecholamines found in brain tissue in supporting melanization using animal brain tissue and synthetic catecholamine mixtures reflecting brain tissue proportions. - MicrobiologyOpen Access
Exploring Cryptococcus neoformans capsule structure and assembly with a hydroxylamine-armed fluorescent probe
Journal of Biological ChemistryVol. 295Issue 13p4327–4340Published online: January 31, 2020- Conor J. Crawford
- Radamés J.B. Cordero
- Lorenzo Guazzelli
- Maggie P. Wear
- Anthony Bowen
- Stefan Oscarson
- and others
Cited in Scopus: 7Chemical biology is an emerging field that enables the study and manipulation of biological systems with probes whose reactivities provide structural insights. The opportunistic fungal pathogen Cryptococcus neoformans possesses a polysaccharide capsule that is a major virulence factor, but is challenging to study. We report here the synthesis of a hydroxylamine-armed fluorescent probe that reacts with reducing glycans and its application to study the architecture of the C. neoformans capsule under a variety of conditions.