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Microbiology
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- MicrobiologyOpen Access
Molecular basis for the structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae
Journal of Biological ChemistryVol. 293Issue 13p4666–4679Published online: February 12, 2018- Bradley R. Clarke
- Olga G. Ovchinnikova
- Steven D. Kelly
- Monica L. Williamson
- Jennifer E. Butler
- Bin Liu
- and others
Cited in Scopus: 24Klebsiella pneumoniae is a major health threat. Vaccination and passive immunization are considered as alternative therapeutic strategies for managing Klebsiella infections. Lipopolysaccharide O antigens are attractive candidates because of the relatively small range of known O-antigen polysaccharide structures, but immunotherapeutic applications require a complete understanding of the structures found in clinical settings. Currently, the precise number of Klebsiella O antigens is unknown because available serological tests have limited resolution, and their association with defined chemical structures is sometimes uncertain.