Molecular Bases of Disease
Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-κB and Yin Yang 1 (YY1)
Background: The mechanism for transcriptional regulation of EAAT1 remains to be elucidated.Results: EGF-activated NF-κB is a positive regulator of EAAT1, whereas manganese-activated YY1, with HDACs acting as co-repressors, is a negative regulator.Conclusion: NF-κB and YY1 are two critical transcriptional regulators of EAAT1.Significance: Identifying the molecular targets of EAAT1 regulation is crucial to develop therapeutics against neurological disorders associated with impairment of EAAT1.
