Molecular Bases of Disease
Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27
Background: Mutations in nucleotide binding domain 1 of cystic fibrosis (CF) transmembrane conductance regulator cause severe CF.Results: Correctors rescue trafficking of ΔF508 by altering interaction with Hsp27 and −40.Conclusion: Rescue of trafficking mutants can be accomplished by combining correctors from different classes.Significance: ΔF508 is the most common mutation. Information on the mechanism of corrector action is critical for treating the majority of patients.
