Molecular Biophysics
Tubulin Tail Sequences and Post-translational Modifications Regulate Closure of Mitochondrial Voltage-dependent Anion Channel (VDAC)
Background: Tubulin C-terminal tail (CTT) peptides bind and block VDAC.Results: CTT-albumin chimeras show that a single CTT suffices for VDAC blockade and that CTTs differ in potency by more than an order of magnitude.Conclusion: Small sequence changes or post-translational modifications in CTT result in substantial changes in VDAC blockage.Significance: Disordered protein tails are not just charged strings, but embody nuanced interaction specificity.
