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Molecular Biophysics
2 Results
- Molecular BiophysicsOpen Access
Solid-state NMR spectroscopy identifies three classes of lipids in Cryptococcus neoformans melanized cell walls and whole fungal cells
Journal of Biological ChemistryVol. 295Issue 44p15083–15096Published online: August 28, 2020- Christine Chrissian
- Emma Camacho
- John E. Kelly
- Hsin Wang
- Arturo Casadevall
- Ruth E. Stark
Cited in Scopus: 13A primary virulence-associated trait of the opportunistic fungal pathogen Cryptococcus neoformans is the production of melanin pigments that are deposited into the cell wall and interfere with the host immune response. Previously, our solid-state NMR studies of isolated melanized cell walls (melanin “ghosts”) revealed that the pigments are strongly associated with lipids, but their identities, origins, and potential roles were undetermined. Herein, we exploited spectral editing techniques to identify and quantify the lipid molecules associated with pigments in melanin ghosts. - Molecular Biophysics Molecular Bases of DiseaseOpen Access
Solid-state NMR Reveals the Carbon-based Molecular Architecture of Cryptococcus neoformans Fungal Eumelanins in the Cell Wall
Journal of Biological ChemistryVol. 290Issue 22p13779–13790Published online: March 30, 2015- Subhasish Chatterjee
- Rafael Prados-Rosales
- Boris Itin
- Arturo Casadevall
- Ruth E. Stark
Cited in Scopus: 41Melanin pigments protect against both ionizing radiation and free radicals and have potential soil remediation capabilities. Eumelanins produced by pathogenic Cryptococcus neoformans fungi are virulence factors that render the fungal cells resistant to host defenses and certain antifungal drugs. Because of their insoluble and amorphous characteristics, neither the pigment bonding framework nor the cellular interactions underlying melanization of C. neoformans have yielded to comprehensive molecular-scale investigation.