Neurobiology
Nuclear Calcium Buffering Capacity Shapes Neuronal Architecture
Background: Calcium-binding proteins regulate calcium dynamics and downstream signaling events.Results: Increasing the calcium buffering capacity of the nucleus alters the expression of genes that regulate neuronal architecture.Conclusion: The nuclear calcium buffering capacity is an important determinant of neuronal morphology.Significance: Nuclear calcium buffers represent a new target for modulating gene expression and neuronal structure.
