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Neurobiology
2 Results
- NeurobiologyOpen Access
Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments
Journal of Biological ChemistryVol. 293Issue 39p15256–15268Published online: August 16, 2018- Songhua Li
- Kota Sato
- William C. Gordon
- Michael Sendtner
- Nicolas G. Bazan
- Minghao Jin
Cited in Scopus: 14The retinal pigment epithelium (RPE)-dependent visual cycle provides 11-cis-retinal to opsins in the photoreceptor outer segments to generate functional visual pigments that initiate phototransduction in response to light stimuli. Both RPE65 isomerase of the visual cycle and the rhodopsin visual pigment have recently been identified as critical players in mediating light-induced retinal degeneration. These findings suggest that the expression and function of RPE65 and rhodopsin need to be coordinately controlled to sustain normal vision and to protect the retina from photodamage. - NeurobiologyOpen Access
Defining a mechanistic link between pigment epithelium–derived factor, docosahexaenoic acid, and corneal nerve regeneration
Journal of Biological ChemistryVol. 292Issue 45p18486–18499Published online: September 26, 2017- Thang Luong Pham
- Jiucheng He
- Azucena H. Kakazu
- Bokkyoo Jun
- Nicolas G. Bazan
- Haydee E.P. Bazan
Cited in Scopus: 42The cornea is densely innervated to sustain the integrity of the ocular surface. Corneal nerve damage produced by aging, diabetes, refractive surgeries, and viral or bacterial infections impairs tear production, the blinking reflex, and epithelial wound healing, resulting in loss of transparency and vision. A combination of the known neuroprotective molecule, pigment epithelium–derived factor (PEDF) plus docosahexaenoic acid (DHA), has been shown to stimulate corneal nerve regeneration, but the mechanisms involved are unclear.