Plant Biology
Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes
Background: Triphosphate tunnel metalloenzymes carry out diverse enzymatic reactions.Results: Two metal co-factors are identified involved in substrate binding and in catalysis.Conclusion: A unified catalytic mechanism is proposed and biochemically investigated.Significance: The functional diversity of TTM enzymes is rationalized by a common mechanism that allows very different substrates to be bound and processed.
