Protein Synthesis and Degradation
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response
Background: eIF2α-P induced GADD34 and constitutively expressed CReP target PP1c to dephosphorylate eIF2α-P to dictate translation control of the ISR.Results: Differential expression of GADD34 and CReP is regulated by upstream ORF (uORF)-mediated ribosome reinitiation.Conclusion: uORFs regulate differential expression of GADD34 and CReP and are important for cell adaptation to stress.Significance: Regulation of eIF2α-P is central for protein homeostasis and cell viability.
