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Withdrawal: Selective cleavage of BLM, the Bloom syndrome protein, during apoptotic cell death.

Open AccessPublished:December 04, 2020DOI:https://doi.org/10.1074/jbc.W120.016689
      VOLUME 276 (2001) PAGES 12068–12075
      This article has been withdrawn by the authors except Dr. Kohwi-Shigematsu, who could not be reached. Fig. 3B has a duplication of the top band in lanes 1 and 3. Fig. 5D has a duplication between the top bands and a horizontal flip of the bottom bands. Fig. 5E likewise has a duplication of the top bands excluding the probe lanes and a horizontal flip of the bottom bands. Fig. 6A has smaller microscopy images pasted on the background of larger microscopy images.

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      • Selective Cleavage of BLM, the Bloom Syndrome Protein, during Apoptotic Cell Death
        Journal of Biological ChemistryVol. 276Issue 15
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          Bloom syndrome (BS) is an autosomal recessive disorder characterized by a high incidence of cancer and genomic instability. BLM, the protein defective in BS, is a RECQ-like helicase that is presumed to function in mammalian DNA replication, recombination, or repair. We show here that BLM, but not the related RECQ-like helicase WRN, is rapidly cleaved in cells undergoing apoptosis. BLM was cleaved to 47- and 110-kDa major fragments, with kinetics similar to the apoptotic cleavage of poly(A)DP-ribose polymerase.
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