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Beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase. Comparison with the phosphodiesterase family.

Open AccessPublished:August 05, 1990DOI:https://doi.org/10.1016/S0021-9258(19)38252-3
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      A group of cDNA clones encoding the beta-subunit of bovine rod photoreceptor cGMP phosphodiesterase were isolated for structural analysis. The encoded polypeptide has 853 residues with a calculated molecular mass of 98 kDa. The beta-subunit is 72% identical to the rod cGMP phosphodiesterase alpha-subunit. Like the alpha-subunit and the cone alpha'-subunit, the beta-subunit belongs to the family of phosphodiesterase genes. The beta- and alpha-subunits are more similar to each other than either is to the cone alpha'-subunit, suggesting either that the beta- and alpha-subunits diverged more recently or that their divergence was restrained by the rod functional environment.

      REFERENCES

        • Stryer L.
        Annu. Rev. Neurosci. 1986; 9: 87-119
        • Baehr W.
        • Devlin M.J.
        • Applebury M.L.
        J. Biol. Chem. 1979; 254: 11669-11677
        • Deterre P.
        • Bigay J.
        • Forquet F.
        • Robert M.
        • Chabre M.
        Proc. Natl. Acad. Sci. U. S. A. 1988; 85: 2424-2428
        • Gillespie P.G.
        • Beavo J.A.
        J. Biol. Chem. 1988; 263: 8133-8141
        • Ovchinnikov Y.A.
        • Gubanov V.V.
        • Khramtsov N.V.
        • Ischenko K.A.
        • Zagranichny V.E.
        • Muradov K.G.
        • Shuvaeva T.M.
        • Lipkin V.M.
        FEBS Lett. 1987; 223: 169-173
        • Ovchinnikov Y.A.
        • Lipkin V.M.
        • Kumarev V.P.
        • Gubanov V.V.
        • Khramtsov N.V.
        • Akhmedov N.B.
        • Zagranichny V.E.
        • Muradov K.G.
        FEBS Lett. 1986; 204: 288-292
        • Li T.
        • Volpp K.
        • Applebury M.L.
        Proc. Natl. Acad. Sci. U. S. A. 1990; 87: 293-297
        • Charbonneau H.
        • Prusti R.K.
        • LeTrong H.
        • Sonnenburg W.K.
        • Mullaney P.J.
        • Walsh K.A.
        • Beavo J.A.
        Proc. Natl. Acad. Sci. U. S. A. 1990; 87: 288-292
        • Chuvpilo S.A.
        • Kravchenko V.V.
        FEBS Lett. 1984; 179: 34-36
        • Maxam A.M.
        • Gilbert W.
        Proc. Natl. Acad. Sci. U. S. A. 1977; 74: 560-564
        • Sanger F.
        • Nicklen S.
        • Coulson A.R.
        Proc. Natl. Acad. Sci. U. S. A. 1977; 74: 5463-5467
        • Mahpoub S.
        • Richard G.
        • Delacourte A.
        • Ham K.D.
        Anal. Biochem. 1986; 154: 171-182
        • Hsu P.-L.
        • Hsu S.M.
        • Appella E.
        Gene Anal. Tech. 1985; 2: 30-36
        • Kozak M.
        Nucleic Acids Res. 1984; 12: 857-872
        • Lipkin V.M.
        • Gubanov V.V.
        • Khramtsov N.V.
        • Obukhov A.N.
        • Ischenko K.A.
        • Ovchinnikov Y.A.
        Retinal Proteins. VNU Science Press, Utrecht, The Netherlands1987: 39-50
        • Persson B.
        • Flinta C.
        • Heijne G.
        • Jornvall H.
        Eur. J. Biochem. 1985; 152: 523-527
        • Charbonneau H.
        • Beier N.
        • Walsh K.A.
        • Beavo J.A.
        Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 9308-9312
        • Stroop S.D.
        • Charbonneau H.
        • Beavo J.A.
        J. Biol. Chem. 1989; 264: 13718-13725
        • Jurnak F.
        Trends Biochem. Sci. 1988; 13: 196-198
        • Holbrook S.R.
        • Kim S.H.
        Proc. Natl. Acad. Sci. U. S. A. 1989; 86: 1751-1755
        • Hancock J.F.
        • Magee T.
        • Childs J.E.
        • Marshall C.J.
        Cell. 1989; 57: 1167-1177
        • Swanson R.J.
        • Applebury M.L.
        J. Biol. Chem. 1983; 258: 10599-10605
        • Ong O.C.
        • Ota I.M.
        • Clarke S.
        • Fung B.K.-K.
        Proc. Natl. Acad. Sci. U. S. A. 1989; 86: 9238-9242
        • Muradov K.G.
        • Natochin M.Y.
        • Bondarenko V.A.
        • Skiba N.P.
        • Lipkin V.M.
        Biol. Membr. 1990; 7 (in press)
        • Chen C.N.
        • Denome S.
        • Davis R.
        Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 9313-9317
        • Davis R.L.
        • Takayasu H.
        • Eberwine M.
        • Myres J.
        Proc. Natl. Acad. Sci. U. S. A. 1989; 86: 3604-3608
        • Sass P.
        • Field J.
        • Nikawa J.
        • Toda T.
        • Wigler M.
        Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 9303-9707