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Journal Article| Volume 265, ISSUE 1, P1-4, January 05, 1990

Signaling through phosphatidylcholine breakdown.

  • J H Exton
    Affiliations
    Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
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Open AccessPublished:January 05, 1990DOI:https://doi.org/10.1016/S0021-9258(19)40184-1
Signaling through phosphatidylcholine breakdown.
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      Several mechanisms of agonist control of PC hydrolysis have been described: control by G proteins, protein kinase C, Ca2+, and tyrosine kinases. The relative importance of these mechanisms remains to be demonstrated. Another major point is the physiological significance of PC hydrolysis. The prolonged formation of DAG from PC may be important in cellular control mechanisms that require long term activation of protein kinase C. The functions of PA are presently unknown, but the rapid formation of high concentrations of this lipid during stimulation by agonists strongly suggests that it has signaling functions. It is obvious that much work remains to define the physiological significance of agonist-stimulated PC breakdown.

      REFERENCES

        • Exton J.H.
        Ritchie J.M. 13th International Conference on Biological Mem branes. Alan R. Liss, Inc., New York1990 (in press)
        • Pelech S.L.
        • Vance D.E.
        Trends Biochem. Sci. 1989; 14: 28-30
        • Pelech S.L.
        • Vance D.E.
        Biochim. Biophys. Acta. 1984; 779: 217-251
        • Mufson R.A.
        • Okin E.
        • Weinstein I.B.
        Carcinogenesis. 1981; 2: 1095-1102
        • Guy G.R.
        • Murray A.W.
        Cancer Res. 1982; 42: 1980-1985
        • Besterman J.M.
        • Duronio V.
        • Cuatrecasas P.
        Proc. Natl. Acad. Sci. U. S. A. 1986; 83: 6785-6789
        • Daniel L.W.
        • Waite M.
        • Wykle R.L.
        J. Biol. Chem. 1986; 261: 9128-9132
        • Liscovitch M.
        • Blusztajn J.K.
        • Freese A.
        • Wurtman R.J.
        Biochem. J. 1987; 241: 81-86
        • Schrey M.P.
        • Read A.M.
        • Steer P.J.
        Biochem. J. 1987; 246: 705-713
        • Cabot M.C.
        • Welsh C.J.
        • Zhang Z.-C.
        • Cao H.-T.
        • Chabbott H.
        • Lebowitz M.
        Biochim. Biophys. Acta. 1988; 959: 46-57
        • Muir J.G.
        • Murray A.W.
        J. Cell. Physiol. 1987; 130: 382-391
        • Takuwa N.
        • Takuwa Y.
        • Rasmussen H.
        Biochem. J. 1987; 243: 647-653
        • Bocckino S.B.
        • Blackmore P.F.
        • Exton J.H.
        J. Biol. Chem. 1985; 260: 14201-14207
        • Charest R.
        • Prpic V.
        • Exton J.H.
        • Blackmore P.F.
        Biochem. J. 1985; 22: 79-90
        • Exton J.H.
        Rev. Physiol. Biochem. Pharmacol. 1988; 111: 118-224
        • Banschbach M.W.
        • Geison R.L.
        • Hokin-Neaverson M.
        Biochim. Biophys. Acta. 1981; 663: 34-35
        • Pickford L.B.
        • Polverino A.J.
        • Barritt G.J.
        Biochem. J. 1987; 245: 211-216
        • Ragab-Thomas J.M.-F.
        • Hullin F.
        • Chap H.
        • Douste-Blazy L.
        Biochim. Biophys. Acta. 1987; 917: 388-397
        • Augert G.
        • Blackmore P.F.
        • Exton J.H.
        J. Biol. Chem. 1989; 264: 2574-2580
        • Polverino A.J.
        • Barritt G.J.
        Biochim. Biophys. Acta. 1988; 970: 75-82
        • Griendling K.K.
        • Rittenhouse S.E.
        • Brock T.A.
        • Ekstein L.S.
        • Gim-brone Jr., M.A.
        • Alexander R.W.
        J. Biol. Chem. 1986; 261: 5901-5906
        • Wright T.M.
        • Rangan L.A.
        • Shin H.S.
        • Raben D.M.
        J. Biol. Chem. 1988; 263: 9374-9380
        • Truett III, A.P.
        • Verghese M.W.
        • Dillon S.B.
        • Snyderman R.
        Proc. Natl. Acad. Sci. U. S. A. 1988; 85: 1549-1553
        • Rosoff P.M.
        • Savage N.
        • Dinarello C.A.
        Cell. 1988; 54: 73-81
        • Whetton A.D.
        • Monk P.N.
        • Consalvey S.D.
        • Huang S.J.
        • Dexter T.M.
        • Downes C.P.
        Proc. Natl. Acad. Sci. U. S. A. 1988; 85: 3284-3288
        • Uhing R.J.
        • Prpic V.
        • Hollenbach P.W.
        • Adams D.O.
        J. Biol. Chem. 1989; 264: 9224-9230
        • Kester M.
        • Simonson M.S.
        • Mené P.
        • Sedor J.R.
        J. Clin. Invest. 1989; 83: 718-723
        • Kennedy D.A.
        J. Biol. Chem. 1987; 262: 16305-16313
        • Pessin M.S.
        • Raben D.M.
        J. Biol. Chem. 1989; 264: 8729-8738
        • Augert G.
        • Bocckino S.B.
        • Blackmore P.F.
        • Exton J.H.
        J. Biol. Chem. 1989; 264: 21689-21698
        • Bocckino S.B.
        • Blackmore P.F.
        • Wilson P.B.
        • Exton J.H.
        J. Biol. Chem. 1987; 262: 15309-15315
        • Rodriguez de Turco E.B.
        • Spitzer J.A.
        Biochem. J. 1988; 253: 73-79
        • Grillone L.R.
        • Clark M.A.
        • Godfrey R.W.
        • Stassen F.
        • Crooke S.T.
        J. Biol. Chem. 1983; 263: 2658-2663
        • Welsh C.J.
        • Cao H.-T.
        • Chabbott H.
        • Cabot M.C.
        Biochem. Biophys. Res. Commun. 1988; 152: 565-572
        • Slivka S.R.
        • Meier K.E.
        • Insel P.A.
        J. Biol. Chem. 1988; 263: 12242-12246
        • Martin T.W.
        • Michaelis K.C.
        Biochem. Biophys. Res. Commun. 1988; 157: 1271-1279
        • Martin T.W.
        • Michaelis K.
        J. Biol. Chem. 1989; 264: 8847-8856
        • Corradetti R.
        • Lindmar R.
        • Löffelholz K.
        Eur. J. Pharmacol. 1982; 85: 123-124
        • Lindmar R.
        • Löffelholz K.
        • Sandmann J.
        Naunyn-Schmiede-bergs Arch. Pharmakol. 1986; 332: 224-229
        • Brehm R.
        • Lindmar R.
        • Löffelholz K.
        J. Neurochem. 1987; 48: 1480-1485
        • Lindmar R.
        • Löffelholz K.
        • Sandmann J.
        Biochem. Pharmacol. 1988; 37: 4689-4695
        • Irving H.R.
        • Exton J.H.
        J. Biol. Chem. 1987; 262: 3440-3443
        • Pai J.-K.
        • Siegel M.I.
        • Egan R.W.
        • Billah M.M.
        Biochem. Biophys. Res. Commun. 1988; 150: 355-364
        • Agwu D.E.
        • McPhail L.C.
        • Wykle R.L.
        • McCall C.E.
        Biochem. Biophys. Res. Commun. 1989; 159: 79-86
        • Agwu D.E.
        • McPhail L.C.
        • Chabot M.C.
        • Daniel L.W.
        • Wykle R.L.
        • McCall C.E.
        J. Biol. Chem. 1989; 264: 1405-1413
        • Pai J.-K.
        • Siegel M.I.
        • Egan R.W.
        • Billah M.M.
        J. Biol. Chem. 1988; 263: 12472-12477
        • Billah M.M.
        • Pai J.-K.
        • Mullmann T.J.
        • Egan R.W.
        • Siegel M.I.
        J. Biol. Chem. 1989; 264: 9069-9076
        • Cabot M.C.
        • Welsh C.J.
        • Cao H.-T.
        • Chabbott H.
        FEBS Lett. 1988; 233: 153-157
        • Martin T.W.
        Biochim. Biophys. Acta. 1988; 962: 282-296
        • Bocckino S.B.
        • Wilson P.B.
        • Exton J.H.
        FEBS Lett. 1987; 225: 201-204
        • Tettenborn C.S.
        • Mueller G.C.
        Biochem. Biophys. Res. Commun. 1988; 155: 249-255
        • Rubin R.
        Biochem. Biophys. Res. Commun. 1988; 156: 1090-1096
        • Liscovitch M.
        • Amsterdam A.
        J. Biol. Chem. 1989; 264: 11762-11767
        • Kobayashi M.
        • Kanfer J.N.
        J. Neurochem. 1987; 48: 1597-1603
        • Gustavsson L.
        • Alling C.
        Biochem. Biophys. Res. Commun. 1987; 142: 958-963
        • Cabot M.C.
        • Welsh C.J.
        • Zhang A.-C.
        • Cao H.-T.
        FEBS Lett. 1989; 245: 85-90
        • Fallman M.
        • Stendahl O.
        • Andersson T.
        Exp. Cell Res. 1989; 181: 217-225
        • Daly P.F.
        • Lyon R.C.
        • Faustino P.J.
        • Cohen J.S.
        J. Biol. Chem. 1987; 262: 14875-14878
        • Farese R.V.
        • Nair G.P.
        • Sierra C.G.
        • Standaert M.L.
        • Pollet R.J.
        • Cooper D.V.
        Biochem. J. 1989; 261: 927-934
        • Rhee S.G.
        • Suh P.-G.
        • Ryu S.-H.
        • Lee S.Y.
        Science. 1989; 244: 546-550
        • Sheikhnejad R.G.
        • Srivastava P.N.
        J. Biol. Chem. 1986; 261: 7544-7549
        • Wolf R.A.
        • Gross R.W.
        J. Biol. Chem. 1985; 260: 7295-7303
        • Matsuzawa Y.
        • Hostetler K.Y.
        J. Biol. Chem. 1980; 255: 646-652
        • Hostetler K.Y.
        • Hall L.B.
        Biochem. Biophys. Res. Commun. 1980; 96: 388-393
        • Kanfer J.N.
        Can. J. Biochem. 1980; 58: 1370-1380
        • Taki T.
        • Kanfer J.N.
        J. Biol. Chem. 1979; 254: 9761-9765
        • Kater L.A.
        • Goetzl E.J.
        • Austen K.F.
        J. Clin. Invest. 1976; 57: 1173-1180
        • Chalifour R.J.
        • Kanfer J.N.
        Biochem. Biophys. Res. Commun. 1980; 96: 742-747
        • Chalifour R.J.
        • Kanfer J.N.
        J. Neurochem. 1982; 39: 299-305
        • Patton G.M.
        • Fasulo J.M.
        • Robins S.J.
        J. Lipid Res. 1982; 23: 190-196
        • Go M.
        • Sekiguchi K.
        • Nomura H.
        • Kikkawa U.
        • Nishizuka Y.
        Biochem. Biophys. Res. Commun. 1987; 144: 598-605
        • Parker P.J.
        • Kour G.
        • Marais R.M.
        • Mitchell F.
        • Pears C.
        • Schaap D.
        • Stabel S.
        • Webster C.
        Mol. Cell. Endocrinol. 1989; 65: 1-11
        • Nishizuka Y.
        Nature. 1988; 334: 661-665
        • Tyagi S.R.
        • Tamura M.
        • Burnham D.N.
        • Lambeth J.D.
        J. Biol. Chem. 1988; 263: 13191-13198
        • Besterman J.M.
        • Pollenz R.S.
        • Booker Jr., E.L.
        • Cuatrecasas P.
        Proc Natl. Acad. Sci. U. S. A. 1986; 83: 9378-9382
        • Kolesnick R.N.
        • Paley A.E.
        J. Biol. Chem. 1987; 262: 9204-9210
        • Salmon D.M.
        • Honeyman T.W.
        Nature. 1980; 284: 344-345
        • Putney Jr., J.W.
        • Weiss S.J.
        • Van de Walle C.M.
        • Haddas R.A.
        Nature. 1980; 284: 345-347
        • Serhan C.
        • Anderson P.
        • Goodman E.
        • Dunham P.
        • Weissmann G.
        J. Biol. Chem. 1981; 256: 2736-2741
        • Ohsaki S.
        • Deguchi T.
        J. Biol. Chem. 1981; 256: 10945-10948
        • Moolenaar W.H.
        • Kruijer W.
        • Tilly B.C.
        • Verlaan I.
        • Bierman A.J.
        • de Laat S.W.
        Nature. 1986; 323: 171-173
        • Murayama T.
        • Ui M.
        J. Biol. Chem. 1985; 260: 7226-7233
        • Holmes R.P.
        • Yoss N.L.
        Nature. 1983; 305: 637-638
        • Clark R.B.
        • Salmon D.
        • Honeyman T.W.
        J. Cyclic Nucleotide Res. 1980; 6: 37-49
        • Proli M.A.
        • Clark R.B.
        • Butcher R.W.
        Mol. Pharmacol. 1985; 28: 331-337
        • Jackowski S.
        • Rock C.O.
        Arch. Biochem. Biophys. 1989; 268: 516-524
        • Kroll M.H.
        • Zovoico G.B.
        • Schafer A.I.
        J. Cell. Physiol. 1989; 139: 558-564
        • Negami A.I.
        • Sasaki H.
        • Yamamura H.
        Eur. J. Biochem. 1986; 157: 587-603
        • Wu C.L.
        • Tsai M.H.
        • Stacey D.W.
        Cell. 1988; 52: 63-71
        • Wolfman A.
        • Macara I.G.
        Nature. 1987; 325: 359-361
        • Lacal J.C.
        • Moscat J.
        • Aaronson S.A.
        Nature. 1987; 330: 269-271

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      Published online: January 05, 1990

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      DOI: https://doi.org/10.1016/S0021-9258(19)40184-1

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